Abstract：
PURPOSE OF INVESTIGATION:1) To assess whether endometrial specimens obtained from removed uteri might show an increase in endometrial pathologies which had been previously diagnosed by hysteroscopy in postmenopausal breast cancer tamoxifen-treated patients. 2) To assess whether hysteroscopy is an efficient method of detecting endometrial pathologies in such patients. METHODS:The findings of two consecutive pathological evaluations in 18 postmenopausal breast cancer tamoxifen-treated patients, performed 11.2+/-11.2 months apart, were compared. The first specimen was collected by hysteroscopy and the second was obtained following hysterectomy. RESULTS:The most significant changes observed were three new cancers diagnosed at hysterectomy, one of which was poorly-differentiated. In the first (hysteroscopy) samplings, one patient had atrophic endometrium, a second patient had endometrial proliferation and a third patient had a benign endometrial polyp. Overall, 55.6% of the study patients had various endometrial pathologies in the first sampling, while 83.3% had endometrial pathologies in the second sampling. However, this difference was not statistically significant. CONCLUSION:1) Endometrial histologic evaluations, performed on removed uteri 11.2+/-11.2 months following previous endometrial samplings of postmenopausal breast cancer tamoxifen-treated patients, showed a non-significant risk of developing overall endometrial pathologies. 2) Hysteroscopy may have missed some endometrial pathologies which were diagnosed later on in specimens obtained by hysterectomy.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Cohen I,Azaria R,Bernheim J,Tepper R,Sharony R,Beyth Ykeywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
418-22issue
4eissn
0392-2936issn
2709-0086journal_volume
21pub_type
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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journal_title：European journal of gynaecological oncology
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更新日期：2013-01-01 00:00:00
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journal_title：European journal of gynaecological oncology
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更新日期：1998-01-01 00:00:00
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