Abstract:
:Two patients presented with anasarca, fevers and sweats. Subsequent evaluation revealed aggressive lymphoproliferative disease. Both patients were treated with CHOP chemotherapy. One patient responded with spontaneous, vigorous diuresis and complete resolution of the edema. She relapsed two months later with recurrent edema that responded a second time to salvage chemotherapy. The second patient died of gram positive sepsis a week after diagnosis. As anasarca is an unusual presenting symptom of non-Hodgkin's lymphoma, we postulated that the malignant cells were secreting a cytokine that resulted in "vascular leakage" of fluid and development of diffuse edema. Several serum cytokine levels were tested. Both patients had elevated TNF-alpha levels, which could have been the cause of the edema; or there might be yet another unidentified mediator that was responsible for the anasarca. We report these two cases to bring to attention the unusual nature of this presentation.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Jillella AP,Day DS,Severson K,Kallab AM,Burgess Rdoi
10.3109/10428190009087034keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
419-22issue
3-4eissn
1042-8194issn
1029-2403journal_volume
38pub_type
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journal_title:Leukemia & lymphoma
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