Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.

Abstract:

:To evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to chronic lymphocytic leukemia (CLL), we conducted a systematic review and meta-analysis of published case-control studies. We identified 36 studies which reported on polymorphic variation in 19 genes and CLL risk. Out of the 23 polymorphic variants, significant associations (p < 0.05) were seen in pooled analyses for only four variants: MDR1, rs1045642; LTA, rs2239704; CD38, rs6449182; and IFNGR1, rs4896243. These findings should be interpreted cautiously, as the estimated false positive report probabilities (FPRPs) for each association were not noteworthy (i.e. FPRP > 0.2). While studies of candidate polymorphisms may be an attractive means of identifying risk factors for CLL, the limited power of published studies to demonstrate statistically significant associations makes it essential that future analyses be based on sample sizes well-powered to identify variants having modest effects on CLL risk.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Sava GP,Speedy HE,Houlston RS

doi

10.3109/10428194.2013.800197

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

160-7

issue

1

eissn

1042-8194

issn

1029-2403

journal_volume

55

pub_type

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