Glioma immunology and immunotherapy.

abstract：OBJECTIVE:To identify the CCM3 gene in a population of 61 families with a positive family history of cerebral cavernous malformations (CCM), 8 of which had suggestive linkage to the CCM3 locus. METHODS:We searched for mutations within the CCM3 interval using a high-throughput screening technique, temperature-gradient ...

journal_title：Neurosurgery

authors： Guclu B,Ozturk AK,Pricola KL,Bilguvar K,Shin D,O'Roak BJ,Gunel M

更新日期：2005-11-01 00:00:00

abstract：:Proton magnetic resonance spectroscopic imaging (1H-MRSI) and positron emission tomography with the tracer L-[1-11C]tyrosine (11C-TYR) were used to localize gliomas for biopsy or resection. This is especially helpful in cases of low-grade gliomas, if these lesions are not visualized by contrast-enhanced computed tomog...

journal_title：Neurosurgery

authors： Go KG,Keuter EJ,Kamman RL,Pruim J,Metzemaekers JD,Staal MJ,Paans AM,Vaalburg W

更新日期：1994-06-01 00:00:00

abstract：:Glossopharyngeal neuralgia is an uncommon cause of facial pain with a relative frequency of 0.2 to 1.3% when compared with trigeminal neuralgia. It is characterized by intermittent, lancinating pain involving the posterior tongue and pharynx, often with radiation to deep ear structures. Since its first description in ...

journal_title：Neurosurgery

authors： Resnick DK,Jannetta PJ,Bissonnette D,Jho HD,Lanzino G

更新日期：1995-01-01 00:00:00

abstract：:The authors report a rare case of traumatic false aneurysm of the middle meningeal artery associated with a delayed contralateral extradural hematoma. The extradural hematoma was evacuated, and the pseudoaneurysm was removed to avoid delayed rupture. The literature on traumatic aneurysms is reviewed. ...

journal_title：Neurosurgery

authors： Salazar Flores J,Vaquero J,Garcia Sola R,Rossi E,Martinez R,Martinez P,Santos H,Bravo G

更新日期：1986-02-01 00:00:00

abstract：:With the advent of magnetic resonance imaging, there has been an increased recognition of schizencephaly during life, especially in epileptic patients. We report our experience with the assessment and treatment of three patients with medically intractable seizures associated with this condition. The three men were age...

journal_title：Neurosurgery

authors： Leblanc R,Tampieri D,Robitaille Y,Feindel W,Andermann F

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND IMPORTANCE:Liposclerosing myxofibrous tumors (LSMFTs) are rare benign fibro-osseous tumors most frequently occurring in the proximal femur. We report the first case of this rare tumor occurring within the calvarium. CLINICAL PRESENTATION:Our patient presented with a 2-yr history of enlarging, painless, ...

journal_title：Neurosurgery

authors： Ploof J,Shaikh H,Melli J,Jour G,Turtz A

更新日期：2019-03-01 00:00:00

abstract：:These experiments were done to develop techniques to expose and manipulate the spinal cord in fetal rats, techniques that could be used to study spinal cord regeneration and transplantation. Adequate maternal anesthesia required a mixture of acepromazine-ketamine supplemented by thiopental. Fetal rats were operated on...

journal_title：Neurosurgery

authors： Albright L

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Capillary telangiectasias, cavernous malformations, and developmental venous anomalies are all vascular malformations that occur on the capillary-venous side of the cerebral circulation. The associations of capillary telangiectasias with venous malformations, cavernous malformations with venous...

journal_title：Neurosurgery

authors： Clatterbuck RE,Elmací I,Rigamonti D

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:If patients with idiopathic normal pressure hydrocephalus (INPH) also have depression, this could have important clinical ramifications in assessment and management of their cognitive function and response to shunting. In many dementias, depression is overrepresented, but the prevalence of depression in shun...

journal_title：Neurosurgery

authors： Israelsson H,Allard P,Eklund A,Malm J

更新日期：2016-02-01 00:00:00

abstract：:Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [...

journal_title：Neurosurgery

authors： Omalu B,Small GW,Bailes J,Ercoli LM,Merrill DA,Wong KP,Huang SC,Satyamurthy N,Hammers JL,Lee J,Fitzsimmons RP,Barrio JR

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Human gliomas are known to be immunosuppressive. Recent reports have suggested novel strategies to overcome this immunosuppression, including immunogene therapy. We examined expression of 10 immunologically important molecules by human gliomas in vitro, and we discuss the implications for immunogene therapy. ...

journal_title：Neurosurgery

authors： Parney IF,Farr-Jones MA,Chang LJ,Petruk KC

更新日期：2000-05-01 00:00:00

abstract：:THE DIRECT ENDONASAL transsphenoidal approach to the sella with the operating microscope was initially described more than 20 years ago. Herein, we describe the technique, its evolution, and lessons learned over a 10-year period for treating pituitary adenomas and other parasellar pathology. From July 1998 to January ...

journal_title：Neurosurgery

authors： Fatemi N,Dusick JR,de Paiva Neto MA,Kelly DF

更新日期：2008-10-01 00:00:00

abstract：:We subtotally removed nine pediatric central gliomas (five brain stem and four thalamic) with the Cavitron ultrasonic surgical aspirator (CUSA). Greater than 70% of the tumor was removed in eight of the nine cases. Evoked potentials were monitored during six of the operations. Of the six children who were operated on ...

journal_title：Neurosurgery

authors： Albright AL,Sclabassi RJ

更新日期：1985-10-01 00:00:00

abstract：:Multiple thoracic disc herniation is rare, and one of the main problems in its treatment has been the lack of accuracy in diagnostic tests. Now, with the advent of computed tomographic scanning with metrizamide in the subarachnoid space, the accuracy has been greatly improved. With computed tomographic scanning, the t...

journal_title：Neurosurgery

authors： Shikata J,Yamamuro T,Iida H,Kashiwagi N

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Intracranial aneurysm rupture prediction is poor, with only a few risk factors for rupture identified and used in clinical practice. OBJECTIVE:To provide an overview of all the risk factors (including genetic, molecular, morphological, and hemodynamic factors) that have potential for use in clinical practic...

journal_title：Neurosurgery

authors： Kleinloog R,de Mul N,Verweij BH,Post JA,Rinkel GJE,Ruigrok YM

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Although real-time localization of gliomas has improved with intraoperative image guidance systems, these tools are limited by brain shift, surgical cavity deformation, and expense. OBJECTIVE:To propose a novel method to perform near-infrared (NIR) imaging during glioma resections based on preclinical and c...

journal_title：Neurosurgery

authors： Lee JY,Thawani JP,Pierce J,Zeh R,Martinez-Lage M,Chanin M,Venegas O,Nims S,Learned K,Keating J,Singhal S

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:This study uses proton magnetic resonance spectroscopy to investigate whether or not idiopathic normal pressure hydrocephalus is associated with neuronal dysfunction or ischemia in the brain. We evaluate whether or not proton magnetic resonance spectroscopy is useful for predicting improvement after long-term...

journal_title：Neurosurgery

authors： Lenfeldt N,Hauksson J,Birgander R,Eklund A,Malm J

更新日期：2008-01-01 00:00:00

abstract：:Brain stem hemorrhage was first recorded in 1812. Its origin has been the subject of much study and experimentation. We review the studies that stress mechanical forces because dynamic axial distortion of the brain stem is a major factor in the physiology and pathology of the central nervous system. ...

journal_title：Neurosurgery

authors： Thompson RK,Salcman M

更新日期：1988-04-01 00:00:00

abstract：:Regional brain tissue catecholamine concentrations were measured in 5 control rats and in 10 rats 72 hours after experimental subarachnoid hemorrhage (SAH). Catecholamine levels were determined in the cerebral hemispheres, brain stem, and cerebellum of each animal using a radioenzymatic assay. Three days after SAH, th...

journal_title：Neurosurgery

authors： Solomon RA,McCormack BM,Lovitz RN,Swift DM,Hegemann MT

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:During its course between the brainstem and the lateral rectus muscle, the abducens nerve usually travels forward as a single trunk, but it is not uncommon for the nerve to split into two branches. The objective of this study was to establish the incidence and the clinical importance of the duplication of the...

journal_title：Neurosurgery

authors： Ozveren MF,Sam B,Akdemir I,Alkan A,Tekdemir I,Deda H

更新日期：2003-03-01 00:00:00

abstract：:Somatosensory evoked potentials (SEPs) were monitored during 113 operations for the clipping of 134 cerebral aneurysms. Changes in peak latency and amplitude of early cortical SEP as well as central conduction time were evaluated. In 58 cases surgical occlusion of arterial vessels or other events occurred, and in 17 o...

journal_title：Neurosurgery

authors： Schramm J,Koht A,Schmidt G,Pechstein U,Taniguchi M,Fahlbusch R

更新日期：1990-01-01 00:00:00

abstract：:Neurosurgery at the University of Michigan was established as a specialty three-quarters of a century ago by Max Minor Peet. It developed under the successive leadership of Edgar Allan Kahn, Richard Coy Schneider, and Julian T. Hoff. Each has made unique contributions to the program, which has a strong tradition of te...

journal_title：Neurosurgery

authors： Hoff JT,Taren JA

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Bone morphogenetic protein (BMP) is used in tens of thousands of spinal fusions each year. A trial evaluating a high-dose BMP formulation demonstrated that its use may be associated with an increased risk of cancer. OBJECTIVE:To evaluate whether BMP, as commonly used today, is associated with an increased r...

journal_title：Neurosurgery

authors： Lad SP,Bagley JH,Karikari IO,Babu R,Ugiliweneza B,Kong M,Isaacs RE,Bagley CA,Gottfried ON,Patil CG,Boakye M

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To review an experience with the posterior interhemispheric approach applied to vascular lesions in the posterior midline, to examine the effects of patient position and gravity retraction of the occipital lobe, and to identify circumstances requiring increased exposure by sectioning the falx and tentorium. ...

journal_title：Neurosurgery

authors： Chi JH,Lawton MT

更新日期：2006-07-01 00:00:00

abstract：:A case of intracerebellar hematoma in infancy is reported. Although the clinical course and computed tomographic appearances suggested a cerebellar tumor, intraoperative and microscopic investigations demonstrated a chronic expanding hematoma enlarging with repeated hemorrhages inside the capsule. The differential dia...

journal_title：Neurosurgery

authors： Aoki N,Mizuguchi K

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:In this study, information about the localization of the central sulcus obtained by magnetic source imaging (MSI) was intraoperatively translated to the brain, using frameless image-guided stereotaxy. In the past, the MSI results could be translated to the surgical space only by indirect methods (e.g., the co...

journal_title：Neurosurgery

authors： Ganslandt O,Steinmeier R,Kober H,Vieth J,Kassubek J,Romstöck J,Strauss C,Fahlbusch R

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Current management of severe brachial plexus injury has undergone recent modifications, and surgical options have expanded. METHODS:The case of a man with a severe closed brachial plexus injury resulting from a motorcycle accident is presented. The patient is found to have upper root avulsions that deprive h...

journal_title：Neurosurgery

authors： Ranalli NJ,Kline DG,McGarvey ML,Boulis NM,Zager EL

更新日期：2008-06-01 00:00:00

abstract：:Clinoidal meningiomas, also referred to as medial or inner sphenoid wing meningiomas, are often difficult and challenging to remove completely and safely, especially when they become large enough to encircle, compress, or displace the adjacent critical neurovascular structures such as the optic nerve, the internal car...

journal_title：Neurosurgery

authors： Lee JH,Sade B,Park BJ

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Intraprocedural rupture is a dangerous complication of endovascular treatment. Small ruptured anterior communicating artery (ACoA) aneurysms and microaneurysms present a challenge for both surgical and endovascular therapies to achieve obliteration. An understanding of the complication rates of treating rupt...

journal_title：Neurosurgery

authors： Schuette AJ,Hui FK,Spiotta AM,Obuchowski NA,Gupta R,Moskowitz SI,Tong FC,Dion JE,Cawley CM

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Cerebral syphilitic gummata are rare manifestations of tertiary, meningovascular syphilis. No extensive characterization of these lesions has been published recently, and only a few small reviews containing imaging findings have been published to date. To better characterize cerebral gummata, we present a cas...

journal_title：Neurosurgery

authors： Fargen KM,Alvernia JE,Lin CS,Melgar M

更新日期：2009-03-01 00:00:00