Elevation of brain norepinephrine concentration after experimental subarachnoid hemorrhage.

Abstract:

:Regional brain tissue catecholamine concentrations were measured in 5 control rats and in 10 rats 72 hours after experimental subarachnoid hemorrhage (SAH). Catecholamine levels were determined in the cerebral hemispheres, brain stem, and cerebellum of each animal using a radioenzymatic assay. Three days after SAH, the tissue concentration of norepinephrine (NE) in the cerebral hemispheres was 64% greater than that in control rats (P less than 0.001). NE levels did not change significantly in either the brain stem or the cerebellum. Most if not all of the NE in the brain tissue rostral to the brain stem is derived from neurons that originate in the locus coeruleus (LC). These data may therefore indicate that the LC is activated after SAH. The possible pathophysiological consequences of activation of the LC in relation to delayed cerebral ischemia after SAH will be discussed.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Solomon RA,McCormack BM,Lovitz RN,Swift DM,Hegemann MT

doi

10.1227/00006123-198609000-00005

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

363-6

issue

3

eissn

0148-396X

issn

1524-4040

journal_volume

19

pub_type

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