Abstract:
:Experimental gliomas were induced in rats by prenatal exposure to ethyl nitrosourea. Changes in the blood-brain barrier were determined by the uptake of a water-soluble compound, 99mTc-glucoheptonate. Increased uptake of 99mTc-glucoheptonate was measured in intact tumors and in various sectors of dissected tumors. The extent of 99mTc-glucoheptonate uptake greatly varied among different tumors and among different sectors of the same tumor. Ultrastructural and cytochemical analysis of the capillary endothelial wall revealed major alterations in tight junctions, which became permeable to horseradish peroxidase. In brain tissue around the tumors, uptake of 99mTc-glucoheptonate and ultrastructure of tight junctions were comparable to normal brain capillaries. The results of the present study indicate that altered endothelial tight junctions may provide the main route of transport of 99mTc-glucoheptonate through the endothelial wall.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Nir I,Levanon D,Iosilevsky Gsubject
Has Abstractpub_date
1989-10-01 00:00:00pages
523-31; discussion 531-2issue
4eissn
0148-396Xissn
1524-4040journal_volume
25pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:To determine the clinical presentation, imaging characteristics, microscopic and ultrastructural characteristics, and treatment outcomes of patients with clinically silent pituitary corticotroph adenomas. METHODS:All silent corticotroph adenomas diagnosed at the Mayo Clinic during the years 1975 through 1997...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200009000-00039
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Bundled care payment models are becoming more prevalent in neurosurgery. Such systems place the cost of postsurgical facilities in the hands of the discharging health system. Opportunity exists to leverage prediction tools for discharge disposition by identifying patients who will not benefit from prolonged ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz161
更新日期:2019-11-01 00:00:00
abstract::We report three cases of the spontaneous resolution of a traumatic chronic epidural hematoma. The patients were young adults with only mild headache after trauma. All patients were treated conservatively because of the very mild symptoms and the time lapse of 1 to 2 weeks between trauma and our unexpected detection of...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198407000-00018
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Machine learning (ML) is a domain of artificial intelligence that allows computer algorithms to learn from experience without being explicitly programmed. OBJECTIVE:To summarize neurosurgical applications of ML where it has been compared to clinical expertise, here referred to as "natural intelligence." ME...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx384
更新日期:2018-08-01 00:00:00
abstract::The effect of a 2 g/kg intravenous bolus of mannitol on intracranial pressure (ICP) and white matter water content was determined by following the time course of ICP and spatial white matter water content after administration of mannitol in a hemispheric cold lesion model of vasogenic edema in the cat. After mannitol ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Lumbar spine degenerative pathologies are prevalent in the United States. The health benefit of spine surgery in the elderly has been questioned. OBJECTIVE:To compare effectiveness, morbidity, and quality of care associated with surgical management of degenerative lumbar spinal disorders in elderly vs nonel...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000952
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Noninvasive observation of degenerating and regenerating peripheral nerves could improve the diagnosis and treatment of nerve injuries. We constructed a novel phased-array radiofrequency coil to permit magnetic resonance imaging (MRI) observation of the sciatic nerve and its target muscles in rats after injur...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000069534.43067.28
更新日期:2003-07-01 00:00:00
abstract::Different fluids used in neurosurgery were tested for the production of blood-brain barrier dysfunction by applying them to the brain surface of the cat for 3 hours. Normal saline, Ringer's solution, and Elliott's Solution B induced no obvious damage either by closed subdural perfusion or when applied to the brain sur...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198007000-00008
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND:Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group. OBJECTIVE:To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms. METHODS:Intrac...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000528
更新日期:2014-12-01 00:00:00
abstract::Two patients with cervical plexiform neurofibromas are presented. Each of these patients had severe cervical kyphosis and has undergone anterior decompression, anterior reconstruction, and posterior stabilization. We discuss the surgical management of cervical kyphotic deformities associated with plexiform neurofibrom...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199411000-00025
更新日期:1994-11-01 00:00:00
abstract::We report the metastasis of a rectal carcinoid to the dura mater of the posterior fossa. The clinical presentation was unusual because of a 10-year latent period between resection of the primary rectal tumor and symptoms and signs of the posterior fossa metastasis; the radiological findings were atypical of a metastas...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197910000-00017
更新日期:1979-10-01 00:00:00
abstract::Excessive mechanical stress on the intervertebral disc may be one of the causes of low back pain. Most studies testing this thesis, however, have been based on quantification of the mechanical response of functional units at failure. Typically, radiography is used to demonstrate trauma to the vertebral body at the fai...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198808000-00006
更新日期:1988-08-01 00:00:00
abstract::Negative findings on four-vessel angiography after a subarachnoid hemorrhage are seen in 5 to 30% of patients. A previously silent lesion in the spinal canal may be responsible for the ictus in a small percentage of this group. The etiological factors include tumors and arteriovenous malformations; however, investigat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199010000-00022
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:The posterior meningeal artery (PMA) normally arises from the vertebral artery; however, its origin varies considerably as the result of its embryological development. This gains clinical significance when associated with vascular pathology. CLINICAL PRESENTATION:A 65-year-old man presented to his local hosp...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000325256.72308.AF
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Long-term remission rates from endoscopic transsphenoidal surgery for acromegaly and their relationship to prognostic indicators of disease aggressiveness are not well documented. OBJECTIVE:To investigate long-term remission rates in patients with acromegaly after endoscopic transsphenoidal surgery, and cor...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx020
更新日期:2017-08-01 00:00:00
abstract::Thromboembolic and ischemic complications frequently occur during and after endovascular procedures, because of associated arterial injury and the thrombogenic characteristics of arterial catheters, contrast agents, and implanted devices such as coils and stents. Platelet adhesion, activation, and aggregation occurrin...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-200006000-00012
更新日期:2000-06-01 00:00:00
abstract::Three patients, ages 69, 67, and 74 years, respectively, underwent surgical removal of cystic cerebellar astrocytomas. All three had past histories pointing to the existence of a cerebellar lesion for many decades prior to surgery: Patient 1 had had nystagmus on lateral gaze on the side of the tumor since early childh...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198908000-00016
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND IMPORTANCE:This article describes delayed endovascular revascularization in a patient with clinical and radiographic evidence of posterior circulation hemodynamic failure in the setting of intracranial occlusive lesions. CLINICAL PRESENTATION:A 48-year-old man presented with a 6-week history of progress...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3182186811
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Spinal surgery costs vary significantly across hospitals and regions, but there is insufficient understanding of what drives this variation. OBJECTIVE:To examine the factors underlying the cost variation for lumbar laminectomy/discectomy and lumbar fusions. METHODS:We obtained patient information (age, gen...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx047
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The objective of this work is to present the preliminary clinical experience we acquired in using the new PoleStar generation, N20 (Medtronic Navigation, Louisville, CO), in a modified conventional operating room. METHODS:PoleStar N20 is a 0.15-T, intraoperative scanner combined with both an integrated optic...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.neu.0000317376.38067.8e
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:The complement system is thought to play a major role in initiating some of the inflammatory events that occur during reperfusion injury. The aim of this study was to assess the effects of C1 esterase inhibitor (C1-INH) on ischemic injury in the rat model of middle cerebral artery suture occlusion and reperfu...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000043710.61233.b4
更新日期:2003-02-01 00:00:00
abstract::We have divided head injury into three categories based on the Glasgow Coma Scale (GCS) (severe, 3-8; moderate, 9-12; and minor, 13-15). In a previous report, we described significant disability after minor head injury. The present report describes 199 patients with moderate head injury, 159 of whom underwent follow-u...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198209000-00002
更新日期:1982-09-01 00:00:00
abstract:Background and importance:Lesions in the corticospinal tract above the decussation at the medullary pyramids almost universally produce contralateral deficits. Rare cases of supratentorial lesions causing ipsilateral motor deficits have been reported previously, but only ever found secondary to stroke or congenital pyr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyw074
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the relative socioeconomic costs of benign cranial base tumors treated with open surgery and gamma knife radiosurgery. METHODS:In a retrospective study, we studied 174 patients with benign cranial base tumors, less than 3 cm in diameter (or volume less than 30 ml), admit...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000209892.42585.9B
更新日期:2006-05-01 00:00:00
abstract::The left middle cerebral artery and both carotid arteries of 17 cats were occluded to evaluate the effects of oxygenated fluorocarbon emulsion on brain ischemia. Carotid and middle cerebral arteries were occluded concurrently for 2 hours, followed by occlusion of the middle cerebral artery only for another 24 hours. S...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198603000-00003
更新日期:1986-03-01 00:00:00
abstract::COSTANZO VAROLIO (CONSTANTIUS Varolius) (1543-1575) was born in Bologna and died in Rome. This professor of anatomy and papal physician was the first to examine the brain from its base up, in contrast with previous dissections of this organ performed from the top down. Varolio was the first to describe many structures...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1227/01.neu.0000317323.63859.2a
更新日期:2008-03-01 00:00:00
abstract::Motor evoked potentials (MEPs) to scalp stimulation have been obtained in 45 control patients and in 70 patients with neurological diseases. Optimal responses were obtained through a pericranial cathode consisting of 6 to 12 regularly spaced, interconnected pericranial cathodal discs whose resistance was carefully bal...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198701000-00035
更新日期:1987-01-01 00:00:00
abstract::Unilateral hydrocephalus in an adult was caused by obstruction of the left foramen of Monro by an intraventricular venous malformation. Magnetic resonance imaging of the region of the foramen of Monro demonstrated the lesion, which subsequently was confirmed to be a venous malformation by angiography and surgery. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199004000-00017
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:Phosphodiesterase-4 (PDE-4) is a cyclic adenosine monophosphate-specific enzyme involved in various inflammatory diseases. We studied its role in and the effect of ibudilast, which predominantly blocks PDE-4, on rat cerebral aneurysms. METHODS:Cerebral aneurysms were induced at the anterior cerebral artery-o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000365771.89576.77
更新日期:2010-03-01 00:00:00
abstract::A silicone, dual cuffed catheter designed for the control of nasal hemorrhage was used for rectal sphincter pressure monitoring. Patients with lipomyelomeningocele and tethered spinal cord were monitored during their operative procedures to aid in distinguishing sacral nerve roots from other tissues. Stimulation of sa...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198905000-00023
更新日期:1989-05-01 00:00:00