Mannitol, intracranial pressure, and vasogenic edema.

Abstract:

:The effect of a 2 g/kg intravenous bolus of mannitol on intracranial pressure (ICP) and white matter water content was determined by following the time course of ICP and spatial white matter water content after administration of mannitol in a hemispheric cold lesion model of vasogenic edema in the cat. After mannitol infusion, maximal ICP reduction occurred at approximately 20 minutes and began to return to baseline after 26 minutes. White matter water content in the control hemisphere began to decrease much later, reaching a minimum at 60 minutes. White matter water content in the lesioned hemisphere was not changed significantly after mannitol infusion. We conclude that the rapid reduction of ICP after intravenous administration of mannitol is not solely due to the dehydration of white matter.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Hartwell RC,Sutton LN

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

444-50; discussion 450

issue

3

eissn

0148-396X

issn

1524-4040

journal_volume

32

pub_type

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