Abstract:
OBJECTIVE AND IMPORTANCE:Liponeurocytomas are rare cerebellar neoplasms in adults, with benign histological features and a favorable clinical prognosis. Current clinical opinion is based on a total of less than 20 published cases and suggests that gross total resection and long-term follow-up monitoring, with possible additional surgery and radiotherapy for treatment of recurrent tumors, represent the best treatment approach for this relatively benign tumor type. CLINICAL PRESENTATION:A 51-year-old Caucasian woman presented with worsening unsteady gait and headaches, suggesting increased intracranial pressure. INTERVENTION:The patient underwent subtotal resection of a cerebellar liponeurocytoma, followed by fractionated radiotherapy (total dose of 54 Gy). She experienced a local recurrence of the tumor 12 months later and underwent additional surgery for removal of the cerebellar mass. A second recurrent tumor was diagnosed on magnetic resonance imaging scans 3 months later and was surgically resected. The tumor histological findings were consistently devoid of atypical features, apart from leptomeningeal invasion noted in the first surgical specimen. CONCLUSION:This unusual case demonstrated an atypical clinical course of a highly aggressive and radiation-resistant tumor, despite the consistent absence of aggressive histological features. Cerebellar liponeurocytomas may not be as benign as the current literature and typical low-grade cytological and histological features suggest.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Jenkinson MD,Bosma JJ,Du Plessis D,Ohgaki H,Kleihues P,Warnke P,Rainov NGdoi
10.1227/01.neu.0000093430.61239.7ekeywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
1425-7; discussion 1428issue
6eissn
0148-396Xissn
1524-4040journal_volume
53pub_type
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