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High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms.

Abstract：

:High molecular weight polyethylene oxides (PEOs) have recently been proposed as an alternative to hydroxypropylmethylcellulose (HPMC) in controlled release matrix tablets. In this study, we compared the performance of PEO and HPMC polymers when employed in the Geomatrix technology, a versatile, well-known method to achieve extended release of drugs at a constant rate. Four core formulations were prepared, containing a soluble drug (diltiazem) and, alternatively, PEO or HPMC of two different viscosity grades. These formulations have the same composition except for the polymer employed. Similarly, four barrier formulations were also prepared, which only differ in the kind of polymer employed. Three-layer Geomatrix systems were then prepared using these core and barrier formulations. The release profiles of the different three-layer systems obtained were compared, to verify if PEO could efficiently replace HPMC in this type of dosage form. The results show that slower release rates can be obtained from the plain matrices containing HPMC compared to PEO, moreover HPMC, used in the barrier formulations, is generally more efficient in controlling drug release rate in three-layer Geomatrix systems.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Maggi L,Bruni R,Conte U

doi

10.1016/s0378-5173(99)00402-0

keywords:

subject

Has Abstract

pub_date

2000-02-15 00:00:00

pages

229-38

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378517399004020

journal_volume

195

pub_type

杂志文章

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