Abstract:
:This study aimed to (1) determine the deposition and clearance rates of ultrafine metallic nickel (Uf-Ni) in rats after a 5 hours single inhalation exposure, and (2) to histopathologically examine the pulmonary lesions induced at dose levels comparable to the Occupational Exposure Limit recommended in Japan (OEL). The exposure concentrations of Uf-Ni for the 3 groups were 0.15 (Low), 1.14 (Medium), and 2.54 (High) mg/m3. Five rats/group were sacrificed at 0 h and 1, 3, 7, 14, and 21 days post exposure. The amount of Ni in the lung accumulated dose-dependently. The half-times for Ni in the lung were estimated as 32 days on average, and were similar to each other regardless of the initial dosage. The histopathologically observed pulmonary lesions induced by a single inhalation of Uf-Ni were, (1) a significant increase in lung weight in the High and Medium groups with time, (2) accumulation of foamy alveolar macrophages (AM), (3) degenerated AM indicating alveolar lipoproteinosis which was aggravated for up to 4 weeks in the High group and (4) acute calcification of the degenerated AM was remarkable. The present results suggest that even a single inhalation of Uf-Ni induces potency of lung lesions at dose levels comparable to the OEL (1 mg/m3 as Ni), or the TWA of ACGIH (1.5 mg/m3 for elemental/metal).
journal_name
Ind Healthjournal_title
Industrial healthauthors
Serita F,Kyono H,Seki Ydoi
10.2486/indhealth.37.353keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
353-63issue
4eissn
0019-8366issn
1880-8026journal_volume
37pub_type
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journal_title:Industrial health
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journal_title:Industrial health
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journal_title:Industrial health
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journal_title:Industrial health
pub_type: 杂志文章
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journal_title:Industrial health
pub_type: 杂志文章
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journal_title:Industrial health
pub_type: 杂志文章
doi:10.2486/indhealth.44.665
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doi:10.2486/indhealth.45.497
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journal_title:Industrial health
pub_type: 杂志文章
doi:10.2486/indhealth.36.61
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journal_title:Industrial health
pub_type: 杂志文章
doi:10.2486/indhealth.36.133
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journal_title:Industrial health
pub_type: 杂志文章
doi:10.2486/indhealth.37.219
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journal_title:Industrial health
pub_type: 临床试验,杂志文章,随机对照试验
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