Abstract:
STUDY DESIGN:Case report. OBJECTIVE:To provide additional information on possible relations between uterine and spinal manifestations of leiomyosarcoma. SUMMARY OF BACKGROUND DATA:Spinal metastases and primary spinal manifestation of leiomyosarcoma and other malignant smooth muscle tumors are rarely observed. METHODS:Clinical and radiologic follow-up of a patient with a spinal tumor. RESULTS:A 46-year-old women had rapidly progressive paraplegia caused by an extramedullary lesion in the extradural space at T2-T3, with spinal cord compression. After surgical decompression, the resected tumor was histologically classified as a leiomyosarcoma. Diagnostic work-up failed to detect the primary tumor site. Previous medical history had been uneventful except for hysterectomy 3 years earlier for a leiomyoma. Extended necroses and focal metaplasia were already described in the hysterectomy specimen indicating malignant disease; however, it was not definitely diagnosed. Multiple leiomyosarcoma metastases developed 22 months later. CONCLUSIONS:In retrospect, the origin of the leiomyosarcoma that manifested in the thoracic spine of the patient must be reconsidered. Rather than a primary dural leiomyosarcoma, this tumor represented the first evidence of recurrence of a missed diagnosis of early-stage uterine leiomyosarcoma.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Nanassis K,Alexiadou-Rudolf C,Tsitsopoulos Pdoi
10.1097/00007632-199905150-00011keywords:
subject
Has Abstractpub_date
1999-05-15 00:00:00pages
987-9issue
10eissn
0362-2436issn
1528-1159journal_volume
24pub_type
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