The pursuit of effective neuroprotection during infant cardiac surgery.

Abstract:

:Advances in infant cardiac surgery have resulted in a dramatic decline in mortality rates; however, neurological morbidity remains an important concern. The effectiveness of a number of interventional strategies to prevent or minimize brain injury during open heart surgery are currently being investigated. This article provides an overview of two approaches: (1) interventions to enhance intraoperative cerebral oxygenation so as to prevent hypoxic-ischemic insults, and (2) the application of cerebral rescue therapies to attenuate the cascade of brain injury. Infant cardiac surgery provides a controlled environment in which to apply these neuroprotective approaches, so as to optimize the quality of life of these vulnerable children.

journal_name

Semin Pediatr Neurol

authors

du Plessis AJ,Johnston MV

doi

10.1016/s1071-9091(99)80047-3

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

55-63

issue

1

eissn

1071-9091

issn

1558-0776

pii

S1071-9091(99)80047-3

journal_volume

6

pub_type

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