Neuronal activity in GP and Vim of parkinsonian patients and clinical changes of tremor through surgical interventions.

Abstract:

:Microrecordings were performed during pallidotomy and thalamotomy for Parkinson's disease (PD). Neuronal activity in globus pallidus (GP) was in general agreement with previous studies of human and primate models of PD. Neuronal activity, where frequency of tremor appeared to oscillate independently from peripheral input, was encountered in GPi. In contrast, neuronal activity in Vim regarding frequency of firing also correlated with tremor and was passively driven by kinesthetic stimuli with a somatotopic arrangement. Pallidal lesions based on microrecording induced relative reductions of tremor, while small Vim lesions immediately alleviated tremor. Basal ganglia pathology due to dopamine depletion could generate oscillatory neuronal activity in GPi, which may cause tremor. However, peripheral feedback to the motor cortex via Vim is also significant for tremorgenesis, because Vim may be an excitatory driving source for motor cortical neurons. Thus, a Vim lesion could reduce excitability of the motor cortical neurons and abolish tremor.

authors

Hayase N,Miyashita N,Endo K,Narabayashi H

doi

10.1159/000029643

keywords:

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

20-8

issue

1

eissn

1011-6125

issn

1423-0372

pii

29643

journal_volume

71

pub_type

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