Anterior polar cataracts in CS rats: a predictor of mature cataract formation.

abstract：PURPOSE:The possible role of protein kinase C (PKC) inhibitors in novel pressure-lowering drugs is currently under investigation. To gain further insight into regulation of contractility by PKC in trabecular meshwork (TM) and ciliary muscle (CM), the effects of various PKC inhibitors and activators were tested. METHOD...

journal_title：Investigative ophthalmology & visual science

authors： Thieme H,Nass JU,Nuskovski M,Bechrakis NE,Stumpff F,Strauss O,Wiederholt M

更新日期：1999-12-01 00:00:00

abstract：:The secretion of the aqueous humor has been proposed to occur as the result of active Na+ transport by a ouabain-sensitive Na-K ATPase. We have examined the localization of this enzyme in the epithelium of rabbit ciliary body pars plicata using [3H]ouabain autoradiography. Single ciliary processes were isolated and in...

journal_title：Investigative ophthalmology & visual science

authors： Usukura J,Fain GL,Bok D

更新日期：1988-04-01 00:00:00

abstract：:In tear fluid, a large number of proteins can be detected with electrophoretic or immunologic techniques. The composition of serum proteins in tears resembles that of whole serum. By comparison of the protein patterns resulting from different sampling methods, it was shown that serum albumin is not present in the secr...

journal_title：Investigative ophthalmology & visual science

authors： Janssen PT,van Bijsterveld OP

更新日期：1983-05-01 00:00:00

abstract：PURPOSE:Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of neovascular AMD; however, risk attributable to genetic variation within pathway genes is unclear. We s...

journal_title：Investigative ophthalmology & visual science

authors： Owen LA,Morrison MA,Ahn J,Woo SJ,Sato H,Robinson R,Morgan DJ,Zacharaki F,Simeonova M,Uehara H,Chakravarthy U,Hogg RE,Ambati BK,Kotoula M,Baehr W,Haider NB,Silvestri G,Miller JW,Tsironi EE,Farrer LA,Kim IK,Park K

更新日期：2014-05-08 00:00:00

abstract：:Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-depe...

journal_title：Investigative ophthalmology & visual science

authors： Tang LQ,Krupin T,Milner M,Woods D,Miller K,Carré DA,Civan MM

更新日期：1991-05-01 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods:Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight su...

journal_title：Investigative ophthalmology & visual science

authors： Kim DY,Song J,Kim JY,Choi K,Hyung S,Chae JB

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Children with idiopathic infantile nystagmus (IIN) exhibit visual acuity deficits that have been modeled in terms of foveation characteristics of the nystagmus waveform. Here we present evidence for an additional component of acuity loss associated with the deprivation experienced during the sensitive period of...

journal_title：Investigative ophthalmology & visual science

authors： Felius J,Muhanna ZA

更新日期：2013-05-01 00:00:00

abstract：:Reaching a consensus in terms of interchangeability and utility (i.e., disease detection/monitoring) of a medical device is the eventual aim of repeatability and agreement studies. The aim of the tolerance and relative utility indices described in this report is to provide a methodology to compare change in clinical m...

journal_title：Investigative ophthalmology & visual science

authors： Bergin C,Guber I,Hashemi K,Majo F

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To assess the aqueous outflow pathway in primary open-angle glaucoma (POAG) through provocative gonioscopy and channelography with a flexible microcatheter and fluorescein tracer during canaloplasty. METHODS:One eye each was randomly selected from 28 consecutive black African POAG patients undergoing canalopla...

journal_title：Investigative ophthalmology & visual science

authors： Grieshaber MC,Pienaar A,Olivier J,Stegmann R

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To determine the response of retinal vessels to differing durations of flicker light (FL) stimulation. METHODS:We recorded retinal arterial and venous vessel dilation to 12.5 Hz FL provocation of varying duration (5, 7, 10, and 20 seconds) in 12 healthy young individuals (age range, 26-45 years). All participa...

journal_title：Investigative ophthalmology & visual science

authors： Heitmar R,Summers RJ

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:Although primary congenital glaucoma (PCG)-associated CYP1B1 mutations in the heterozygous state have been evaluated for association with primary open-angle glaucoma (POAG) in several small studies, their contribution to the occurrence of POAG is still controversial. The present study was conducted to determine...

journal_title：Investigative ophthalmology & visual science

authors： Pasutto F,Chavarria-Soley G,Mardin CY,Michels-Rautenstrauss K,Ingelman-Sundberg M,Fernández-Martínez L,Weber BH,Rautenstrauss B,Reis A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To evaluate the kinetics, receptor specificity, molecular basis, and site selectivity of the endocrine and neural regulation of secretory component (SC) synthesis by rat lacrimal gland acinar cells. METHODS:Acinar cells from the rat lacrimal and submandibular glands, as well as epithelial cells (IEC-6) from th...

journal_title：Investigative ophthalmology & visual science

authors： Lambert RW,Kelleher RS,Wickham LA,Vaerman JP,Sullivan DA

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Local first-order multifocal electroretinogram (mfERG) implicit time (K1-IT) delays have proved to be important and predictive indicators of retinal function in diabetes. To better understand the nature of these delays, the authors examined the spatial association between K1-IT and second-order amplitudes (K2-S...

journal_title：Investigative ophthalmology & visual science

authors： Bronson-Castain KW,Bearse MA Jr,Han Y,Schneck ME,Barez S,Adams AJ

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD. METHODS:Fifty-seven Chinese subjects with clinically diagnosed FCD and 121 normal control subjects were recruited. Genomic DNA was extr...

journal_title：Investigative ophthalmology & visual science

authors： Thalamuthu A,Khor CC,Venkataraman D,Koh LW,Tan DT,Aung T,Mehta JS,Vithana EN

更新日期：2011-07-29 00:00:00

abstract：:The authors investigated the mechanisms underlying the head shaking shown by some patients with congenital nystagmus (CN). In order to improve visual function by head shaking, a patient with CN must have some visual acuity loss due to retinal image motion created by the nystagmus; an abnormal vestibulo-ocular reflex (...

journal_title：Investigative ophthalmology & visual science

authors： Carl JR,Optican LM,Chu FC,Zee DS

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To determine whether corneal acidosis, which occurs during contact lens wear, alters corneal O2 consumption (QO2) and if so, whether increased ion transport activity could contribute to altered QO2 during acidosis. METHODS:PO2 was measured, using the phosphorescence quenching of Pd-meso-tetra-(4-carboxyphenyl)...

journal_title：Investigative ophthalmology & visual science

authors： Harvitt DM,Bonanno JA

更新日期：1998-12-01 00:00:00

abstract：:PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its potential substrates in the context of primary RPE cell extracellular milieu. METHODS. Primary RPE cell cultures were established from human donor eyes and screened f...

journal_title：Investigative ophthalmology & visual science

authors： An E,Sen S,Park SK,Gordish-Dressman H,Hathout Y

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To quantify the role of anterior zonular tension on the optomechanical lens response during simulation of accommodation in primates. METHODS:Postmortem cynomolgus monkey eyes (n = 14; age range, 3.0-11.5 years) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, ...

journal_title：Investigative ophthalmology & visual science

authors： Nankivil D,Manns F,Arrieta-Quintero E,Ziebarth N,Borja D,Amelinckx A,Bernal A,Ho A,Parel JM

更新日期：2009-08-01 00:00:00

abstract：:The laser Doppler technique was used to measure alterations in retinal blood flow in human subjects under dark-adapted conditions compared to light-adapted conditions. Retinal blood flow increased 40 to 70% after the transition from light to dark. We show quantitatively that the measured increases in retinal blood flo...

journal_title：Investigative ophthalmology & visual science

authors： Feke GT,Zuckerman R,Green GJ,Weiter JJ

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:We previously developed a method to measure visual function progression using "Progression sectors," which were derived from a clustering analysis of pointwise rates of glaucomatous visual field (VF) progression; however, only short series of VFs, where pointwise linear regression (PLR) is typically not reliabl...

journal_title：Investigative ophthalmology & visual science

authors： Hirasawa K,Murata H,Asaoka R

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To test the effects of subconjunctival topotecan (TPT) in fibrin sealant (FS) in transgenic murine retinoblastoma (RB). METHODS:Growth inhibitory, apoptotic, and cell cycle effects of TPT were assayed in human RB cell lines. In a dose-escalation study, eight groups of three 10- to 14-week-old wild-type mice we...

journal_title：Investigative ophthalmology & visual science

authors： Tsui JY,Dalgard C,Van Quill KR,Lee L,Grossniklaus HE,Edelhauser HF,O'Brien JM

更新日期：2008-02-01 00:00:00

abstract：:Corneas of fetal and young albino rabbits were examined by light and transmission electron microscopy. In addition, DNA and hydroxyproline content were measured in developing stroma. The results were compared with similar data from healing corneas in adult rabbits and from developing corneas of other animal species. I...

journal_title：Investigative ophthalmology & visual science

authors： Cintron C,Covington H,Kublin CL

更新日期：1983-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of TNF-alpha on leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis (EIU) in the rat. METHODS:EIU was induced in Long-Evans rats by a single footpad injection of lipopolysaccharide (LPS; 350 microg/kg) from Salmonella typhimurium. A single injec...

journal_title：Investigative ophthalmology & visual science

authors： Koizumi K,Poulaki V,Doehmen S,Welsandt G,Radetzky S,Lappas A,Kociok N,Kirchhof B,Joussen AM

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:In normal eyes and in diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cell survival is critically important. Bcl-x(L) has been shown to be among the most highly expressed survival factors in cultured human RPE cells. In the curr...

journal_title：Investigative ophthalmology & visual science

authors： Zhang N,Peairs JJ,Yang P,Tyrrell J,Roberts J,Kole R,Jaffe GJ

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Strabismus that develops shortly after birth is known to cause temporal-to-nasal eye movement asymmetries under monocular viewing. The neural mechanisms underlying this deficit are not well understood. In the current study, the hypothesis that this eye movement anomaly reflects a similar asymmetry in the direct...

journal_title：Investigative ophthalmology & visual science

authors： Watanabe I,Bi H,Zhang B,Sakai E,Mori T,Harwerth RS,Smith EL 3rd,Chino YM

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Linkage intervals for erosive vitreoretinopathy (ERVR) and Wagner disease previously were found to overlap at 5q14.3. In a Japanese family with Wagner disease, a CSPG2/Versican splice site mutation (c.4004-2A-->G) was recently reported that resulted in a 39-nucleotide exon 8 in-frame deletion. We investigated w...

journal_title：Investigative ophthalmology & visual science

authors： Mukhopadhyay A,Nikopoulos K,Maugeri A,de Brouwer AP,van Nouhuys CE,Boon CJ,Perveen R,Zegers HA,Wittebol-Post D,van den Biesen PR,van der Velde-Visser SD,Brunner HG,Black GC,Hoyng CB,Cremers FP

更新日期：2006-08-01 00:00:00

abstract：Purpose:We assessed changes in age-specific prevalence of refractive error at the time of starting school, by comparing preschool and school age cohorts in Shanghai, China. Methods:A cross-sectional study was done in Jiading District, Shanghai during November and December 2013. We randomly selected 7 kindergartens and...

journal_title：Investigative ophthalmology & visual science

authors： Ma Y,Qu X,Zhu X,Xu X,Zhu J,Sankaridurg P,Lin S,Lu L,Zhao R,Wang L,Shi H,Tan H,You X,Yuan H,Sun S,Wang M,He X,Zou H,Congdon N

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To study age-related changes in the refractive index distribution of the human ocular lens. METHODS:Biometric data collected on 48 eyes in subjects ranging in age from 19 to 31 years and 48 eyes in subjects ranging in age from 49 to 61 years allowed estimation of a single parameter related to the refractive in...

journal_title：Investigative ophthalmology & visual science

authors： Hemenger RP,Garner LF,Ooi CS

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS:MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline....

journal_title：Investigative ophthalmology & visual science

authors： Sasamoto Y,Gomi F,Sawa M,Sakaguchi H,Tsujikawa M,Nishida K

更新日期：2011-02-16 00:00:00

abstract：Purpose:A recent proposal for why glaucomatous perimetric sensitivities of approximately 15 to 19 dB or less are unreliable involves the idea that the neural response of normal retinal ganglion cells saturates for intense perimetric stimuli. A predicted consequence of this saturation is that the neural response for two...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ,McKendrick AM,Turpin A

更新日期：2016-11-01 00:00:00