Abstract:
BACKGROUND:Most patients with thyroid cancer suffer from salivary gland (SG) dysfunctions after radioiodine (RI) therapy. We investigated the effects of keratinocyte growth factor (KGF)-1 on RI-induced SG dysfunction in an animal model. METHODS:Six C57BL/6 mice were assigned to each of the following groups: treatment naïve control group, RI group, and RI+KGF-1 group. Body and SG weights, salivary flow rates, salivary lag times and changes in 99mTc pertechnetate uptake and excretion were measured, and histologic changes were noted. Amylase activities and epidermal growth factor (EGF) concentrations in saliva were also measured. In addition, TUNEL assays were performed and apoptosis-related protein expressions were assessed. RESULTS:RI-induced reductions in salivary flow rates and increases in salivary lag times observed in the RI group were not observed in RI+KGF-1 group. Mice in RI group had higher HIF1a levels than controls, but HIF1a levels in RI+KGF-1 group were similar to those in control group. Furthermore, mice in RI+KGF-1 group had more mucin stained acini and decreased periductal fibrosis than mice in RI group, and tissue remodeling of many salivary epithelial cells (AQP5) and endothelial cells (CD31) were observed in RI+KGF-1 group. Amylase activity and expression in saliva were greater in RI+KGF-1 group than in RI group, and fewer apoptotic cells were observed in RI+KGF-1 group. Furthermore, BCLxl (anti-apoptotic) expression was higher, and Bax (pro-apoptotic) expression was lower in RI+KGF-1 group than in RI group. CONCLUSIONS:Local delivery of KGF-1 might prevent RI-induced SG damage by reducing apoptosis.
journal_name
Int J Environ Res Public Healthauthors
Kim JM,Choi ME,Kim SK,Kim JW,Kim YM,Choi JSdoi
10.3390/ijerph17176322subject
Has Abstractpub_date
2020-08-31 00:00:00issue
17eissn
1661-7827issn
1660-4601pii
ijerph17176322journal_volume
17pub_type
杂志文章abstract::Noise-induced hearing loss (NIHL) is an important occupational disease worldwide resulting from interactions between genetic and environmental factors. The purpose of this study was to examine whether genetic variations in POU4F3 and GRHL2 may influence susceptibility to NIHL in the Chinese population. A matched case-...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13060561
更新日期:2016-06-03 00:00:00
abstract::Indoor physical environments appear to influence learning efficiency nowadays. For improvement in learning efficiency, environmental scenarios need to be designed when occupants engage in different learning tasks. However, how learning efficiency is affected by indoor physical environment based on task types are still...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15061256
更新日期:2018-06-13 00:00:00
abstract::In the latest literature search, the technology based on graphite oxide (GO) nanomaterials exhibits a great potential in many aspects of wastewater treatment involving adsorption, photocatalysis, disinfection and membrane process. In this study experimental data involving the carbon element in different forms such as ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17165862
更新日期:2020-08-13 00:00:00
abstract::The carbon emission problem in China needs to be solved urgently. Industrial symbiosis, as an effective means to improve resource efficiency, can better alleviate the carbon emission problem. Under such a circumstance, this paper regards an industrial symbiosis system as a collection of producers, consumers and decomp...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16071093
更新日期:2019-03-27 00:00:00
abstract::The aim of this study was to explore knowledge, practice of risk and guidelines of the novel corona virus disease (COVID-19) infection among the eye care practitioners and the potential associated factors. A cross-sectional self-administered online survey was distributed via emails and social media networks between 2n...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17145141
更新日期:2020-07-16 00:00:00
abstract::Industrial development in India has rarely been studied through the perspective of environmental justice (EJ) such that the association between industrial development and significant economic and social inequalities remains to be examined. Our article addresses this gap by focusing on Gujarat in western India, a leadi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16010042
更新日期:2018-12-25 00:00:00
abstract::The metallurgical industry is a significant component of the national economy. The main purpose of this study was to establish a composite risk analysis method for fatal accidents in the metallurgical industry. We collected 152 fatal accidents in the Chinese metallurgical industry from 2001 to 2018, including 141 majo...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17113790
更新日期:2020-05-27 00:00:00
abstract::Mental health (MH) has a relevant burden on the health of populations. Common MH disorders (anxiety and non-psychotic depression) are well associated to socioeconomic individual and neighborhood characteristics, but little is known about the influence of urban structure. We analyzed among a Turin (Northwest Italy) urb...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph121114898
更新日期:2015-11-20 00:00:00
abstract::Background: A systematic review was undertaken to explore access to general healthcare services for people with disabilities in low and middle-income countries (LMICs). Methods: Six electronic databases were searched in February 2017. Studies comparing access to general healthcare services by people with disabilities ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15091879
更新日期:2018-08-30 00:00:00
abstract::To examine the effect of sildenafil on erectile dysfunction (ED) and psychosocial outcomes in alcohol-dependent (AD) men, 108 men with these diagnoses were randomly assigned to either take sildenafil (50 mg) as add-on to standard treatment for AD, or the same treatment without sildenafil, for 12 weeks. Only 50 patient...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3390/ijerph6092510
更新日期:2009-09-01 00:00:00
abstract::Large amounts of aerosol particles suspended in the atmosphere pose a serious challenge to the climate and human health. In this study, we produced a dataset through merging the Moderate Resolution Imaging Spectrometers (MODIS) Collection 6.1 3-km resolution Dark Target aerosol optical depth (DT AOD) with the 10-km re...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16193522
更新日期:2019-09-20 00:00:00
abstract::The changing nature of employment and work causes new demands in society, such as work-life balance, that has emerged in labor relations as an important aspect of a healthy work environment. In this context, Best Companies to Work for are a reference in caring for their staff, and it is well known that new generations...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16245122
更新日期:2019-12-15 00:00:00
abstract::An epidemic of chronic kidney disease of unknown origin (CKDu) has emerged in the past two decades in agricultural communities, characterized by progressive renal failure with a dearth of early clinical symptoms. The aim of this study is to improve understanding of the natural history of this disease and to evaluate t...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17228552
更新日期:2020-11-18 00:00:00
abstract::The Mediterranean region is vulnerable to climatic changes. A warming trend exists in the basin with changes in rainfall patterns. It is expected that vector-borne diseases (VBD) in the region will be influenced by climate change since weather conditions influence their emergence. For some diseases (i.e., West Nile vi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph120606745
更新日期:2015-06-15 00:00:00
abstract::Silver Nanoparticles (AgNPs), an epitome of nanotechnology, appear in everyday products such as water filters, printer ink, toothpaste, food packaging and cosmetics mostly due to their bactericidal properties. Given this high level of public exposure, the safety of AgNPs has never been fully established. The unsafe us...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16010148
更新日期:2019-01-08 00:00:00
abstract::Drinking water, a fluid primarily for human hydration, is also a source of mineral nutrients. Groundwater, a drinking water source for more than 70% of inhabitants living in Asian deltas, has received much attention because of its naturally occurring arsenic, but the linkage of arsenic toxicity with other water consti...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13010081
更新日期:2015-12-26 00:00:00
abstract::Mycobacterium avium (MA) is a potential food safety hazard in pigs. Blood samples of slaughtered pigs in the Netherlands and Germany were tested for the presence of MA antibodies to estimate the serological prevalence in the tested population. In the Dutch and German population 1.0% and 1.7% samples were positive, and...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph10094027
更新日期:2013-08-30 00:00:00
abstract::The escalated burden of diabetes on the population's health has catalyzed rigorous scientific research to produce appropriate evidence for treatment and control. Malaysia suffers from the leading diabetes epidemic within the Western Pacific region. It is crucial to map the scientific landscape of diabetes research for...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18010318
更新日期:2021-01-04 00:00:00
abstract::This study aimed to describe the epidemiological characteristics, the occupational context, and the cost of hospitalised work-related traumatic spinal injuries, across New South Wales, Australia. A record-linkage study of hospitalised cases of work-related spinal injury (ICD10-AM code U73.0 or workers compensation) wa...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15102121
更新日期:2018-09-27 00:00:00
abstract::Menarche is the first occurrence of a woman's menstruation, an event that symbolizes reproductive capacity and the transition from childhood into womanhood. The global average age for menarche is 12 years and this has been declining in recent years. Many factors that affect the timing menarche in girls could be affect...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17051703
更新日期:2020-03-05 00:00:00
abstract::This research examined international Muslim travelers' intention formation of a non-Islamic country. Our proposed theoretical framework encompassing inconvenient tourism experience, mental health, hedonic value experience, and satisfaction included a sufficient level of predictive power for intent. These variables pla...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18020758
更新日期:2021-01-18 00:00:00
abstract::Background: The academic literature contains little information regarding the interventions that create age-friendly cities and communities in order to promote active ageing. Objectives: A systematic review was carried out to determine the available empirical evidence in relation to the characteristics, content and ef...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17228305
更新日期:2020-11-10 00:00:00
abstract::Leading Italian studies support the use of γ-hydroxybutyric acid (GHB), not only in the treatment of the alcohol withdrawal syndrome, but also in maintaining alcohol abstinence. GHB gives a better result than naltrexone and disulfiram in maintaining abstinence, and it has a better effect on craving than placebo or dis...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph8072816
更新日期:2011-07-01 00:00:00
abstract::This study aimed to assess the impacts of heat waves during the summer of 2015 on mortality in the Czech Republic and to compare them with those of heat waves back to the previous record-breaking summer of 1994. We analyzed daily natural-cause mortality across the country's entire population. A mortality baseline was ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14121562
更新日期:2017-12-13 00:00:00
abstract::Background: Depressive symptoms during pregnancy may cause unfavorable consequences for both the mother and the infant's physiological and psychological health. Recent evidence indicates that body image plays an important role in prenatal depression. The present study's main purpose was to investigate the level of acc...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17249436
更新日期:2020-12-16 00:00:00
abstract::The Chinese Government has played an important role in organizing the evacuation of typhoon disasters, and in-depth analysis of individual behavioral decisions is a prerequisite for adopting an effective emergency organization plan. Existing evacuation plans only consider how the Government issues the early warning an...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17030682
更新日期:2020-01-21 00:00:00
abstract::The objective of this study is to examine the spillover effects of chronic diseases experienced by spouses on their wives or husbands' labour supply. Using data from 2010 and 2012 of the China Family Panel Studies (CFPS), this study employed a difference-in-difference (DD) strategy to investigate the average treatment...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16214214
更新日期:2019-10-30 00:00:00
abstract::South Africa leads the world with the number of people infected with HIV. Even with all attempts that have been made to curb HIV, it is still evident that new infections are on the rise. Condom use remains one of the best tools against this challenge yet a small number of sexually active men use them. This study inves...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14040339
更新日期:2017-03-23 00:00:00
abstract::Background: Characterizing the determinants of the abuse liability of electronic cigarettes (ECs) in adolescents is needed to inform product regulation by the United States Food and Drug Administration (FDA). We recently reported that Vuse Menthol EC aerosol extract containing nicotine and a range of non-nicotine cons...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17030860
更新日期:2020-01-30 00:00:00
abstract::Misperception of nutritional status is common and hinders the progress of childhood obesity prevention. This study aimed to examine the effectiveness of a smartphone-assisted intervention to improve student and parental perception of students' nutritional status (underweight, normal weight, overweight, obese). We cond...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17165932
更新日期:2020-08-15 00:00:00