Abstract:
:Noise-induced hearing loss (NIHL) is an important occupational disease worldwide resulting from interactions between genetic and environmental factors. The purpose of this study was to examine whether genetic variations in POU4F3 and GRHL2 may influence susceptibility to NIHL in the Chinese population. A matched case-control study was carried out among 293 hearing loss individuals and 293 normal hearing workers drawn from a population of 3790 noise-exposed workers. Ten single-nucleotide polymorphisms (SNPs) in POU4F3 and GRHL2 were selected and genotyped. Logistic regression was performed to analyze the main effects of SNPs and the interactions between noise exposure and SNPs. Moreover, the interactions between predictor haplotypes and noise exposure were also analyzed. Analysis revealed that the CC genotype of rs1981361 in the GRHL2 gene was associated with a higher risk of NIHL (adjusted OR = 1.59; 95% CI: 1.08-2.32, p = 0.018). Additionally, the GG genotype of rs3735715 in the GRHL2 gene was also a risk genotype (adjusted OR = 1.48; 95% CI: 1.01-2.19, p = 0.046). Significant interactions were found between rs3735715, rs1981361 (GRHL2), rs1368402 as well as rs891969 (POU4F3) and noise exposure in the high-level exposure groups. Furthermore, the protective haplotype CA in the POU4F3 gene and the risk haplotype GCCG in the GRHL2 gene were identified combined with noise exposure. These results indicated that GRHL2 might be an NIHL susceptibility gene, but the effect of POU4F3 on NIHL could only be detected when taking noise exposure into account, and their effects were enhanced by higher levels of noise exposure. However, the differences were not significant after the Bonferroni correction was applied. These results should be seen as suggestive.
journal_name
Int J Environ Res Public Healthauthors
Xu X,Yang Q,Jiao J,He L,Yu S,Wang J,Gu G,Chen G,Zhou W,Wu H,Li Y,Zhang Hdoi
10.3390/ijerph13060561subject
Has Abstractpub_date
2016-06-03 00:00:00issue
6eissn
1661-7827issn
1660-4601pii
ijerph13060561journal_volume
13pub_type
杂志文章abstract::The main research objective of this study was seeking the predictive role of closeness to parents, attachment, identity style, identity commitment, type of relationship, and having children in intimacy among young women and men. Many studies indicate differences in the level of engagement, communication, and satisfact...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16224447
更新日期:2019-11-13 00:00:00
abstract::This study was carried out to determine the risk factors of leptospirosis infection among local urban service workers in Sabah. This is a cross-sectional study involving 394 workers in Kota Kinabalu City, Sabah, conducted from February to March 2017. Information on demography, occupational exposures and environmental ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17020427
更新日期:2020-01-08 00:00:00
abstract::Identifying nitrogen-transforming genes and the microbial community in the lacustrine sedimentary environment is critical for revealing nitrogen cycle processes in eutrophic lakes. In this study, we examined the diversity and abundance of ammonia-oxidizing bacteria (AOB), ammonia-oxidizing archaea (AOA), denitrifying ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16132298
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:Despite a long average lifespan, increased life expectancy does not guarantee higher quality of life. METHODS:To contribute in understanding some determinants of healthy life expectancies in older Japanese individuals in a snowy winter region, we investigated the indicators of health. Local residents (n = 1...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17155316
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVE:A large number of studies have shown the adverse neonatal outcomes of maternal psychological ill health. Given the potentially high prevalence of antenatal anxiety and few studies performed among Chinese people, the authors wanted to investigate the prevalence of antenatal anxiety and associated factors among...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13050468
更新日期:2016-05-04 00:00:00
abstract::Background: Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women's health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Unt...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph14030334
更新日期:2017-03-22 00:00:00
abstract::Australian Aboriginal pregnant women have a high smoking prevalence (45%). Health professionals lack adequate educational resources to manage smoking. Resources need to be tailored to ensure saliency, cultural-sensitivity and account for diversity of Indigenous populations. As part of an intervention to improve health...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14101148
更新日期:2017-09-29 00:00:00
abstract::Sedentary behaviors are an important issue worldwide, as prolonged sitting time has been associated with health problems. Recently, active workstations have been developed as a strategy to counteract sedentary behaviors. The present study examined the rationale and perceptions of university students’ and staff f...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15061242
更新日期:2018-06-12 00:00:00
abstract::Since Anderson's now classic, Code of the Street: Decency, Violence, and the Moral Life of the Inner City, an increasing number of researchers have found a significant association between the code of the street and antisocial behavior. Less researched, however, is the relationship between the code of the street and co...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17072432
更新日期:2020-04-03 00:00:00
abstract::As a "starting zone" and "amplifier" of global climate change, the Qinghai-Tibet Plateau is very responsive to climate change. The global temperature rise has led directly to an acceleration of glacial melting in the plateau and various glacier avalanche disasters have frequently occurred. The landslide caused by glac...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16234707
更新日期:2019-11-26 00:00:00
abstract::This article describes a collaboration among a group of university faculty, undergraduate students, local governments, local residents, and U.S. Army staff to address long-standing concerns about the environmental health effects of an Army ammunition plant. The authors describe community-responsive scientific pilot st...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17051695
更新日期:2020-03-05 00:00:00
abstract::To reduce the burden of chronic disease, the Centers for Disease Control and Prevention (CDC) funded the Orange County Partnerships to Improve Health (OC-PICH) project in Orange County, California. One of the strategies included adding outdoor exercise equipment (OEE) in two parks in Garden Grove and Anaheim. Using a ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17072605
更新日期:2020-04-10 00:00:00
abstract::Careful conceptualization and differentiation of both spirituality and religiosity is a necessary precondition for understanding the potential role they play in health, whether physical or mental. The aim of this study was to explore the associations of spirituality with self-rated health, health complaints, and life ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15122781
更新日期:2018-12-07 00:00:00
abstract::Although the role of systemic proinflammatory cytokines, IL-1beta and TNF-alpha, and their up-regulation of adhesion molecules, ICAM-1, VCAM-1 and E-Selectin, in the pathogenesis of cerebral malaria (CM) is well established, the role of local cytokine release remain unclear. Immunohistochemistry (IHC) was used to comp...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph2005010123
更新日期:2005-04-01 00:00:00
abstract::Alcohol-exposed pregnancies are a health issue for many American Indian communities. The goal of this manuscript is to outline how an existing alcohol-exposed pregnancy prevention program with non-pregnant women (Project CHOICES) was modified to fit the needs and norms of an American Indian community. The Oglala Sioux...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13010001
更新日期:2015-12-22 00:00:00
abstract::Swimming exercise at sea level causes a transient decrease in lung diffusing capacity for carbon monoxide (DLCO). The exposure to hypobaric hypoxia can affect lung gas exchange, and hypoxic pulmonary vasoconstriction may elicit pulmonary oedema. The purpose of this study is to evaluate whether there are changes in DLC...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17103501
更新日期:2020-05-17 00:00:00
abstract::This study sought to describe the mental health problems experienced by Korean disaster survivors, using a qualitative research method to provide empirical resources for effective disaster mental health support in Korea. Participants were 16 adults or elderly adults who experienced one or more disasters at least 12 mo...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15020362
更新日期:2018-02-18 00:00:00
abstract::Over the past half century, a surprising number of major pollution incidents occurred due to tailings dam failures. Most previous studies of such incidents comprised forensic analyses of environmental impacts after a tailings dam failure, with few considering the combined pollution risk before incidents occur at a wat...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph121214983
更新日期:2015-12-02 00:00:00
abstract::Background: Given the risk of physical and psychosocial health that emerge in adolescents that are continuing into adulthood, identifying and addressing early signs of health-related quality of life (HRQoL) decline provides an opportunity to ensure that young people have a healthier progression through adolescence. Ai...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16132324
更新日期:2019-07-01 00:00:00
abstract::Knowledge is considered to be an important resource; it is the source of competitive advantage. However, if knowledge is managed well with Knowledge Management (KM), then it becomes a source for sustainable competitive advantage for organizations. If KM is implemented in an organization, it would improve the organizat...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15122816
更新日期:2018-12-10 00:00:00
abstract::Social interactions where a person is addressed by their correct name and pronouns, consistent with their gender identity, are widely recognized as a basic and yet critical aspect of gender affirmation for transgender people. Informed by the Model of Gender Affirmation, we developed a self-report measure of the import...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17249525
更新日期:2020-12-19 00:00:00
abstract::Multiple sclerosis (MS) is an autoimmune disease in which the immune system reacts by damaging the central nervous system, specifically myelin and oligodendrocytes. It is the most debilitating neurological disease among young adults, causing personal, familiar, social, and professional limitations. Multiple sclerosis ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17113979
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND:Prolonged sedentary behaviour (SB) is associated with risk of chronic diseases. Digital interventions in SB require mixed method evaluations to understand potential for impact in real-world settings. In this study, the RE-AIM QuEST evaluation framework will be used to understand the potential of a digital he...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17124538
更新日期:2020-06-24 00:00:00
abstract::Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility. It is the most prevalent chronic liver disease worldwide. With rapid lifestyle transitions, its prevalence worldwide is increasi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17061818
更新日期:2020-03-11 00:00:00
abstract::Maternal and child survival is a major public health problem in haor areas in Bangladesh. Fathers feel responsible as expressed by their capability "to save the future". Using the Capability Framework for Child Growth, we aimed to identify what contextual factors underlie a father's real opportunities to secure a safe...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17165781
更新日期:2020-08-10 00:00:00
abstract::Shiga toxin-producing Escherichia coli (STEC) causes a wide spectrum of diseases, including hemorrhagic colitis and hemolytic uremic syndrome (HUS). Almost 5% of STEC infections result from waterborne exposures, yet there is no test listed in the EPA's current Selected Analytical Methods for the detection of active Sh...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17217901
更新日期:2020-10-28 00:00:00
abstract::Amongst the main objectives of physical education (PE) classes is the consolidation of healthy lifestyle habits in young people and adolescents. Nonetheless, these classes can also provide the basis from which adverse experiences are generated which affect students' perceptions of these classes. Previously conducted s...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16224444
更新日期:2019-11-12 00:00:00
abstract::Chronic cigarette smoking is associated with numerous abnormalities in brain neurobiology, but few studies specifically investigated the chronic effects of smoking (compared to the acute effects of smoking, nicotine administration, or nicotine withdrawal) on cerebral perfusion (i.e., blood flow). Predominately middle-...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph120708198
更新日期:2015-07-16 00:00:00
abstract::Soil microorganisms play a key role in global biogeochemical changes. To understand the interactions among soil bacterial communities and their responses to extreme environments, the soil properties and bacterial community diversity were determined in the post-mining ecosystem of the Loess Plateau, China. The results ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16244892
更新日期:2019-12-04 00:00:00
abstract::(1) The aim of this study was to identify the association between post-materialism and health care use (in terms of the frequency of doctor visits and the reason for doctor visits). (2) Data were taken from the German General Social Survey (a representative sample of individuals aged 18 years and over, n = 3338). The ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17238869
更新日期:2020-11-28 00:00:00