Abstract：
:Background: Characterizing the determinants of the abuse liability of electronic cigarettes (ECs) in adolescents is needed to inform product regulation by the United States Food and Drug Administration (FDA). We recently reported that Vuse Menthol EC aerosol extract containing nicotine and a range of non-nicotine constituents (e.g., menthol, propylene glycol) had reduced aversive effects compared to nicotine alone in adolescent rats, whereas Aroma E-Juice EC aerosol extract did not. The current study used a behavioral economic approach to compare the relative abuse liability of these EC extracts and nicotine alone in an i.v. self-administration (SA) model in adolescents. Methods: Adolescents were tested for the SA of EC extracts prepared using an ethanol (ETOH) solvent or nicotine and saline, with and without 4% ETOH (i.e., the same concentration in the EC extracts) in 23 h/day sessions. Results. Although acquisition of SA was faster for nicotine + ETOH compared to all other formulations, the elasticity of demand for all nicotine-containing formulations was similar. Conclusions: EC aerosol extracts did not have greater abuse liability than nicotine alone in adolescents. These data suggest that nicotine may be the primary determinant of the abuse liability of these ECs in youth, at least in terms of the primary reinforcing effects of ECs mediated within the central nervous system.
journal_name
Int J Environ Res Public Healthauthors
Harris AC,Smethells JR,Palumbo M,Goniewicz M,LeSage MGdoi
10.3390/ijerph17030860subject
Has Abstractpub_date
2020-01-30 00:00:00issue
3eissn
1661-7827issn
1660-4601pii
ijerph17030860journal_volume
17pub_type
杂志文章abstract：:The familial social background of a child can significantly impact their behavior and health. We investigated associations between socio-economic status (SES) and health parameters and behaviors in German children and adolescents. Data were collected between 2011 and 2018 in the framework of the LIFE Child study. Part...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16050677
更新日期：2019-02-26 00:00:00
abstract：:To characterise the burden of work-related injuries in South Australia, workers' compensation claim data were obtained from SafeWork South Australia between 2000 and 2014. Descriptive analyses were performed to investigate the burden of work-related injuries by age, gender, occupation, industry, and nature and mechani...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17062015
更新日期：2020-03-18 00:00:00
abstract：:Considerable research on the risk factors of obesity and chronic diseases has focused on relationships between where people live, where they shop, and the types of food they purchase. Rarely have investigators used a national sample and explicitly addressed the amount of energy-dense and nutrient-poor foods purchased ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17207517
更新日期：2020-10-15 00:00:00
abstract：:The global challenges caused by socio-economic inequalities, climate change and environmental damage caused to ecosystems, require changes in human behavior at all organizational levels, including companies, governments, communities, and individuals. In this context, it is important to analyse how social and creative ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17072527
更新日期：2020-04-07 00:00:00
abstract：BACKGROUND:In this paper, we aimed to investigate the potential impacts of a fire accident in a fertilizer warehouse on chromosomal anomalies, including Trisomy 21 (T21) and Trisomy (T18) among pregnancies in Brazos County, Texas. We conducted an observational study in Brazos County, TX, with all patients of T18 and T2...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17072561
更新日期：2020-04-08 00:00:00
abstract：:The aim of this study was to explore the prevalence, pattern, and social determinants of chronic conditions multimorbidity among chronic disease primary care patients in four Greater Mekong countries (Cambodia, Myanmar, Thailand, and Vietnam). In a cross-sectional survey, chronic disease patients accessing primary car...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14091019
更新日期：2017-09-06 00:00:00
abstract：:The aim of the study was to estimate the dietary exposure to acrylamide (AA) from the consumption of various processed food and to assess the associated health risks in different age groups in Korea. Potato crisps and French fries presented the highest mean levels of AA (546 and 372 μg/kg, respectively) followed by co...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17207619
更新日期：2020-10-19 00:00:00
abstract：:The relationship between parenting styles and teen dating violence has become a relevant research topic in recent years, especially related to violence inflicted online. To more fully understand this relationship, the objective of the present study was to examine which parenting style (authoritarian, indulgent, author...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16152722
更新日期：2019-07-30 00:00:00
abstract：:This study assessed the impact of an educational intervention on the knowledge, attitudes, and practice regarding Type 2 Diabetes Mellitus (T2DM) of Primary Health Care (PHC) professionals, as well as on the types of T2DM care services which they were able to provide. The intervention was carried out in collaboration ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17062076
更新日期：2020-03-20 00:00:00
abstract：:As the main material in indoor furniture, southern yellow pine (Pinus spp.) releases volatile organic compounds (VOCs) into the environment during use. To better understand variations in the contents of VOCs in southern yellow pine before and after heat treatment, this study conducts dry heat treatment on southern yel...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15112579
更新日期：2018-11-18 00:00:00
abstract：:Although it has been more than 40 years since "health for all" was presented as a focus in the Alma Ata declaration [...]. ...
journal_title：International journal of environmental research and public health
pub_type： 社论
doi：10.3390/ijerph17051696
更新日期：2020-03-05 00:00:00
abstract：:Globally, gastrointestinal (GI) infections by enteric pathogens are the second-leading cause of morbidity and mortality in children under five years of age (≤5 years). While GI pathogen exposure in households has been rigorously examined, there is little data about young children's exposure in public domains. Moreover...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15081646
更新日期：2018-08-03 00:00:00
abstract：:Suicide attempts and suicidal ideation in adolescence are considered to be related to suicide and psychiatric adversity later in life. Secondary prevention by improving the treatment of suicidal youth is a distinct possibility. In this study, treatment with a systematised mood-regulation focused cognitive behavioural ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,随机对照试验
doi：10.3390/ijerph15050921
更新日期：2018-05-05 00:00:00
abstract：BACKGROUND:Environmental tobacco smoke (ETS) exposure is associated with altered cytokine levels in children. We sought to examine ETS exposure prevalence and the relationship between ETS exposure and cytokine levels in a sample of hospitalized children. (2) Methods: Inflammatory markers (IL-8, IL-1β, IL-10, and TNF-α)...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16234625
更新日期：2019-11-21 00:00:00
abstract：:This study aimed to integrate and analyze the existing studies and to explore research trends and hotspots related to the effects of xenobiotics on glucose metabolism in male testes. All articles were retrieved from the PubMed database, from an inception date up to 10 June 2017. CiteSpace software (version 5.1.R8 SE) ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15081590
更新日期：2018-07-26 00:00:00
abstract：:Recent media attention has focused on the risks that agricultural pesticides pose to the environment and human health; thus, these topics provide focal areas for scientists and science educators to enhance public understanding of basic toxicology concepts. This study details the development of a quantitative inventory...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph8061923
更新日期：2011-06-01 00:00:00
abstract：:Asbestos is still used in Mongolia in the energy and construction sectors, among others. However, limited data is available on asbestos consumption and asbestos-related disease in Mongolia. The purpose of this paper is to present the available information on the importation of asbestos into Mongolia. We used data on a...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15010136
更新日期：2018-01-15 00:00:00
abstract：:Malaria is one of the highest contributors to morbidity and mortality in Zimbabwe. However, there is paucity of knowledge regarding disability adjusted life years (DALYs) as a measure of burden of malaria in affected communities. The DALYs metric was used to assess the burden of malaria in Gwanda District with the aim...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph13020244
更新日期：2016-02-22 00:00:00
abstract：:Persons affected by migration require health systems that are responsive and adaptable to the needs of both disadvantaged migrants and non-migrant populations. The objective of this study is to support health systems for populations affected by migration. MATERIALS AND METHODS:An international Delphi consensus proces...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14020144
更新日期：2017-02-03 00:00:00
abstract：:This study tested whether information on positive food additives and negative food additives had an effect on consumers' risk perception and their willingness to accept (WTA) food with additives. Consumers' WTA was examined via a random nth-price auction of exchanging freshly squeezed orange juice without additives fo...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15112394
更新日期：2018-10-29 00:00:00
abstract：BACKGROUND:This study aims to identify the association between parenting styles and behavioral changes among adolescents regarding the consumption of alcohol, tobacco, cannabis, cocaine/crack. METHODS:A group of ninety-nine adolescents (39 girls and 60 boys), aged 14 to 19 years (17.05 ± 1.51), who called in to a call...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16183432
更新日期：2019-09-16 00:00:00
abstract：BACKGROUND:Information on psychological impact of COVID-19 quarantine in primary ciliary dyskinesia (PCD), a chronic disorder with recurrent pulmonary exacerbations, is lacking. Psychological well-being was prospectively assessed during COVID-19 lockdown in Italy in a PCD population. METHODS:we recruited 27 PCD patien...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17218099
更新日期：2020-11-03 00:00:00
abstract：:Fungal community analyses in homes have been attracting attention because fungi are now generally considered to be allergens. Currently, these analyses are generally conducted using the culture method, although fungal communities in households often contain species that are difficult to culture. In contrast, next-gene...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17165842
更新日期：2020-08-12 00:00:00
abstract：:Standing desks have proven to be effective and viable solutions to combat sedentary behavior among children during the school day in studies around the world. However, little is known regarding the potential of such interventions on cognitive outcomes in children over time. The purpose of this pilot study was to deter...
journal_title：International journal of environmental research and public health
pub_type： 临床试验,杂志文章
doi：10.3390/ijerph13010059
更新日期：2015-12-22 00:00:00
abstract：:Background: Older lesbian, gay, bisexual and trans (LGBT) residents are often invisible in long-term care settings. This article presents findings from a community-based action research project, which attempted to address this invisibility through co-produced research with LGBT community members. Particular Question: ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15040695
更新日期：2018-04-07 00:00:00
abstract：:Indigenous Peoples in high-income countries experience higher burdens of food insecurity, obesity, and diet-related health conditions compared to national averages. The objective of this systematic scoping review is to synthesize information from the published literature on the methods/approaches, findings, and scope ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17238818
更新日期：2020-11-27 00:00:00
abstract：:Bullying is a worldwide problem that has serious effects on the mental health of both victims and perpetrators. Although bullying seems related to increasing globalization and migration, it has seldom been researched in this context. This exploratory study examined bullying experiences and related depressive symptoms ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17134776
更新日期：2020-07-02 00:00:00
abstract：:Climate change is negatively impacting the health of Canadians and is accordingly expected to have a significant impact on public health agencies and their response to these health impacts throughout the twenty-first century. While national and international research and assessments have explored the potential human h...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15102237
更新日期：2018-10-12 00:00:00
abstract：:This paper aims to provide direct and indirect evidence on setting up rules for applications of the empirical Bayes shrinkage (EBS), and offers cautionary remarks concerning its applicability. In epidemiology, there is still a lack of relevant criteria in the application of EBS. The bias of the shrinkage estimator is ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph7020380
更新日期：2010-02-01 00:00:00
abstract：:Mobile genetic elements play an important role in the dissemination of antibiotic resistant bacteria among human and environmental sources. Therefore, the aim of this study was to determine the occurrence and patterns of integrons and insertion sequences of extended-spectrum β-lactamase (ESBL)-producing Escherichia co...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15102308
更新日期：2018-10-20 00:00:00
