Abstract:
BACKGROUND:Despite numerous trials investigating robot-assisted therapy (RT) effects on upper-extremity (UE) function after stroke, few have explored the relationship between three-dimensional (3D) reach-to-target kinematics and clinical outcomes. The objectives of this study were to 1) investigate the correlation between kinematic parameters of 3D reach-to-target movements and UE clinical outcome measures, and 2) examine the degree to which differences in kinematic parameters across individuals can account for differences in clinical outcomes in response to RT. METHODS:Ten chronic stroke survivors participated in a pilot RT intervention (eighteen 1-h sessions) integrating cognitive skills training and a home-action program. Clinical outcome measures and kinematic parameters of 3D reach-to-target movements were collected pre- and post-intervention. The correlation between clinical outcomes and kinematic parameters was investigated both cross-sectionally and longitudinally (i.e., changes in response to the intervention). Changes in clinical outcomes and kinematic parameters were tested for significance in both group and subject-by-subject analyses. Potential associations between individual differences in kinematic parameters and differences in clinical outcomes were examined. RESULTS:Moderate-to-strong correlation was found between clinical measures and specific kinematic parameters when examined cross-sectionally. Weaker correlation coefficients were found longitudinally. Group analyses revealed significant changes in clinical outcome measures in response to the intervention; no significant group changes were observed in kinematic parameters. Subject-by-subject analyses revealed changes with moderate-to-large effect size in the kinematics of 3D reach-to-target movements pre- vs. post-intervention. Changes in clinical outcomes and kinematic parameters varied widely across participants. CONCLUSIONS:Large variability was observed across subjects in response to the intervention. The correlation between changes in kinematic parameters and clinical outcomes in response to the intervention was variable and not strong across parameters, suggesting no consistent change in UE motor strategies across participants. These results highlight the need to investigate the response to interventions at the individual level. This would enable the identification of clusters of individuals with common patterns of change in response to an intervention, providing an opportunity to use cluster-specific kinematic parameters as a proxy of clinical outcomes. TRIAL REGISTRATION:ClinicalTrials.gov, NCT02747433 . Registered on April 21st, 2016.
journal_name
J Neuroeng Rehabiljournal_title
Journal of neuroengineering and rehabilitationauthors
Adans-Dester C,Fasoli SE,Fabara E,Menard N,Fox AB,Severini G,Bonato Pdoi
10.1186/s12984-020-00730-1subject
Has Abstractpub_date
2020-08-08 00:00:00pages
106issue
1issn
1743-0003pii
10.1186/s12984-020-00730-1journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Robot-assisted gait therapy is increasingly being used in pediatric neurorehabilitation to complement conventional physical therapy. The robotic device applied in this study, the Lokomat (Hocoma AG, Switzerland), uses a position control mode (Guidance Force), where exact positions of the knee and hip joints ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/s12984-017-0287-1
更新日期:2017-07-14 00:00:00
abstract::The existing shortage of therapists and caregivers assisting physically disabled individuals at home is expected to increase and become serious problem in the near future. The patient population needing physical rehabilitation of the upper extremity is also constantly increasing. Robotic devices have the potential to ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,评审
doi:10.1186/1743-0003-11-3
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:Functional electrical stimulation (FES) during repetitive practice of everyday tasks can facilitate recovery of upper limb function following stroke. Reduction in impairment is strongly associated with how closely FES assists performance, with advanced iterative learning control (ILC) technology providing pr...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/1743-0003-11-105
更新日期:2014-06-30 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1186/1743-0003-7-37
更新日期:2010-07-29 00:00:00
abstract::Unfortunately, the original version of this article [1] contained an error. Equation 6 was included incorrectly: in the original equation variable slinks3 was missing.The correct Equation 6 can be found below: ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 已发布勘误
doi:10.1186/s12984-015-0106-5
更新日期:2015-12-04 00:00:00
abstract:BACKGROUND:Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor contro...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-11-170
更新日期:2014-12-19 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-016-0114-0
更新日期:2016-01-20 00:00:00
abstract:BACKGROUND:Individuals with severe neurological disabilities but preserved cognition, including children, are often precluded from connecting with their environments. Brain computer interfaces (BCI) are a potential solution where advancing technologies create new clinical opportunities. We evaluated clinician awareness...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-019-0624-7
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Understanding how prostheses are used in everyday life is central to the design, provision and evaluation of prosthetic devices and associated services. This paper reviews the scientific literature on methodologies and technologies that have been used to assess the daily use of both upper- and lower-limb pro...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00711-4
更新日期:2020-07-14 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-5-16
更新日期:2008-05-27 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-017-0294-2
更新日期:2017-08-25 00:00:00
abstract:BACKGROUND:Myoelectric control of upper extremity powered prostheses has been used clinically for many years, however this approach has not been fully developed for lower extremity prosthetic devices. With the advent of powered lower extremity prosthetic components, the potential role of myoelectric control systems is ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-9-29
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Robot-based rehabilitation for persons post-stroke may improve arm function and daily-life activities as measured by clinical scales, but its effects on motor strategies during functional tasks are still poorly investigated. This study aimed at assessing the effects of robot-therapy versus arm-specific physi...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12984-020-0646-1
更新日期:2020-01-30 00:00:00
abstract::Even though feedback is considered to play an important role in learning how to operate a brain-computer interface (BCI), to date no significant influence of feedback design on BCI-performance has been reported in literature. In this work, we adapt a standard motor-imagery BCI-paradigm to study how BCI-performance is ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-34
更新日期:2010-07-27 00:00:00
abstract::The general objective of the "Rehabilitation Medicine Summit: Building Research Capacity" was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The five elements of research capacity that guided the discussions were: 1) researchers; 2) research culture, en...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-3-1
更新日期:2006-01-03 00:00:00
abstract:BACKGROUND:Generating appropriate balancing reactions in response to unexpected loss of balance during walking is important to prevent falls. The purpose of this study was to assess dynamic balancing responses following pushes to the pelvis in groups of post-stroke and healthy subjects. METHODS:Forty-one post-stroke s...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00710-5
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:Rhythmic Auditory Stimulation (RAS) can compensate for the loss of automatic and rhythmic movements in patients with idiopathic Parkinson's disease (PD). However, the neurophysiological mechanisms underlying the effects of RAS are still poorly understood. We aimed at identifying which mechanisms sustain gait...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12984-019-0533-9
更新日期:2019-06-07 00:00:00
abstract:BACKGROUND:Functional electrical stimulation (FES) has been used to improve function in individuals with hemiparesis following stroke. An ideal functional electrical stimulation (FES) system needs an accurate mathematical model capable of designing subject and task-specific stimulation patterns. Such a model was previo...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-5-7
更新日期:2008-02-27 00:00:00
abstract:OBJECTIVE:To study the effects of reduced lighting on the gait of older adults with a high level gait disorder (HLGD) and to compare their response to that of healthy elderly controls. METHODS:22 patients with a HLGD and 20 age-matched healthy controls were studied under usual lighting conditions (1000 lumens) and in ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-2-27
更新日期:2005-08-28 00:00:00
abstract:BACKGROUND:Robotic and non-robotic training devices are increasingly being used in the rehabilitation of upper limb function in subjects with neurological disorders. As well as being used for training such devices can also provide ongoing assessments during the training sessions. Therefore, it is mandatory to understan...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-9-37
更新日期:2012-06-09 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-4-25
更新日期:2007-07-10 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-4-13
更新日期:2007-05-09 00:00:00
abstract:BACKGROUND:Prediction of Gait intention from pre-movement Electroencephalography (EEG) signals is a vital step in developing a real-time Brain-computer Interface (BCI) for a proper neuro-rehabilitation system. In that respect, this paper investigates the feasibility of a fully predictive methodology to detect the inten...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00675-5
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Powered exoskeletons are a promising approach to restore the ability to walk after spinal cord injury (SCI). However, current exoskeletons remain limited in their walking speed and ability to support tasks of daily living, such as stair climbing or overcoming ramps. Moreover, training progress for such advan...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-018-0360-4
更新日期:2018-03-13 00:00:00
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journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-22
更新日期:2010-05-21 00:00:00
abstract:BACKGROUND:People with a lower-extremity amputation that use conventional passive-elastic ankle-foot prostheses encounter a series of stress-related challenges during walking such as greater forces on their unaffected leg, and may thus be predisposed to secondary musculoskeletal injuries such as chronic joint disorders...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-10-49
更新日期:2013-06-07 00:00:00
abstract::The study of gait variability, the stride-to-stride fluctuations in walking, offers a complementary way of quantifying locomotion and its changes with aging and disease as well as a means of monitoring the effects of therapeutic interventions and rehabilitation. Previous work has suggested that measures of gait variab...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-2-19
更新日期:2005-07-20 00:00:00
abstract:BACKGROUND:Recent studies have shown that neural stimulation can be used to provide artificial sensory feedback to amputees eliciting sensations referred on the amputated hand. The temporal properties of the neural stimulation modulate aspects of evoked sensations that can be exploited in a bidirectional hand prosthesi...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00737-8
更新日期:2020-08-15 00:00:00
abstract::The original use of biofeedback to train single muscle activity in static positions or movement unrelated to function did not correlate well to motor function improvements in patients with central nervous system injuries. The concept of task-oriented repetitive training suggests that biofeedback therapy should be deli...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-3-11
更新日期:2006-06-21 00:00:00
abstract:BACKGROUND:Advances such as targeted muscle reinnervation and pattern recognition control may provide improved control of upper limb myoelectric prostheses, but evaluating user function remains challenging. Virtual environments are cost-effective and immersive tools that are increasingly used to provide practice and ev...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/s12984-018-0402-y
更新日期:2018-09-05 00:00:00