Abstract:
BACKGROUND:Cerebellar symptoms are extremely disabling and are common in Multiple Sclerosis (MS) subjects. In this feasibility study, we developed and tested a robot therapy protocol, aimed at the rehabilitation of incoordination in MS subjects. METHODS:Eight subjects with clinically defined MS performed planar reaching movements while grasping the handle of a robotic manipulandum, which generated forces that either reduced (error-reducing, ER) or enhanced (error-enhancing, EE) the curvature of their movements, assessed at the beginning of each session. The protocol was designed to adapt to the individual subjects' impairments, as well as to improvements between sessions (if any). Each subject went through a total of eight training sessions. To compare the effect of the two variants of the training protocol (ER and EE), we used a cross-over design consisting of two blocks of sessions (four ER and four EE; 2 sessions/week), separated by a 2-weeks rest period. The order of application of ER and EE exercises was randomized across subjects. The primary outcome measure was the modification of the Nine Hole Peg Test (NHPT) score. Other clinical scales and movement kinematics were taken as secondary outcomes. RESULTS:Most subjects revealed a preserved ability to adapt to the robot-generated forces. No significant differences were observed in EE and ER training. However over sessions, subjects exhibited an average 24% decrease in their NHPT score. The other clinical scales showed small improvements for at least some of the subjects. After training, movements became smoother, and their curvature decreased significantly over sessions. CONCLUSIONS:The results point to an improved coordination over sessions and suggest a potential benefit of a short-term, customized, and adaptive robot therapy for MS subjects.
journal_name
J Neuroeng Rehabiljournal_title
Journal of neuroengineering and rehabilitationauthors
Vergaro E,Squeri V,Brichetto G,Casadio M,Morasso P,Solaro C,Sanguineti Vdoi
10.1186/1743-0003-7-37subject
Has Abstractpub_date
2010-07-29 00:00:00pages
37issn
1743-0003pii
1743-0003-7-37journal_volume
7pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The overall goal of this paper was to investigate approaches to controlling active participation in stroke patients during robot-assisted gait therapy. Although active physical participation during gait rehabilitation after stroke was shown to improve therapy outcome, some patients can behave passively durin...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-8-14
更新日期:2011-03-23 00:00:00
abstract:BACKGROUND:Hand synergies have been extensively studied over the last few decades. Objectives of such research are numerous. In neuroscience, the aim is to improve the understanding of motor control and its ability to reduce the control dimensionality. In applied research fields like robotics the aim is to build biomim...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-11-113
更新日期:2014-07-30 00:00:00
abstract:BACKGROUND:People with severe motor impairments often require an alternative access pathway, such as a binary switch, to communicate and to interact with their environment. A wide range of access pathways have been developed from simple mechanical switches to sophisticated physiological ones. In this manuscript we repo...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-6-11
更新日期:2009-04-16 00:00:00
abstract:BACKGROUND:Rehabilitation robotics is progressing towards developing robots that can be used as advanced tools to augment the role of a therapist. These robots are capable of not only offering more frequent and more accessible therapies but also providing new insights into treatment effectiveness based on their ability...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-10-102
更新日期:2013-09-28 00:00:00
abstract:BACKGROUND:Activities of daily living frequently require children to make rapid decisions and execute desired motor actions while inhibiting unwanted actions. Children with hemiparetic cerebral palsy due to perinatal stroke may have deficits in executive functioning in addition to motor impairments. The objective of th...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00714-1
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Gait abnormalities have been reported in individuals with Chronic Fatigue Syndrome (CFS) however no studies exist to date investigating the kinematics of individuals with CFS in over-ground gait. The aim of this study was to compare the over-ground gait pattern (sagittal kinematics and temporal and spatial) ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-5-16
更新日期:2008-05-27 00:00:00
abstract::BACKGROUND: Monitoring body kinematics has fundamental relevance in several biological and technical disciplines. In particular the possibility to exactly know the posture may furnish a main aid in rehabilitation topics. In the present work an innovative and unobtrusive garment able to detect the posture and the movem...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-2-8
更新日期:2005-03-02 00:00:00
abstract:BACKGROUND:Event-related desynchronization/synchronization (ERD/ERS) is a relative power decrease/increase of electroencephalogram (EEG) in a specific frequency band during physical motor execution and mental motor imagery, thus it is widely used for the brain-computer interface (BCI) purpose. However what the ERD real...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-11-90
更新日期:2014-05-30 00:00:00
abstract:BACKGROUND:Previous reports of the mechanics and energetics of post-stroke hemiparetic walking have either not combined estimates of mechanical and metabolic energy or computed external mechanical work based on the limited combined limbs method. Here we present a comparison of the mechanics and energetics of hemipareti...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-015-0012-x
更新日期:2015-02-27 00:00:00
abstract:BACKGROUND:People with severe disabilities, e.g., due to neurodegenerative disease, depend on technology that allows for accurate wheelchair control. For those who cannot operate a wheelchair with a joystick, brain-computer interfaces (BCI) may offer a valuable option. Technology depending on visual or auditory input m...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-11-7
更新日期:2014-01-16 00:00:00
abstract::Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-7
更新日期:2010-02-11 00:00:00
abstract::Unfortunately, the original version of this article [1] contained an error. Equation 6 was included incorrectly: in the original equation variable slinks3 was missing.The correct Equation 6 can be found below: ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 已发布勘误
doi:10.1186/s12984-015-0106-5
更新日期:2015-12-04 00:00:00
abstract:BACKGROUND:Body weight support (BWS) systems have shown promise as rehabilitation tools for neurologically impaired individuals. This paper reviews the experiment-based research on BWS systems with the aim: (1) To investigate the influence of body weight unloading (BWU) on gait characteristics; (2) To study whether the...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-018-0380-0
更新日期:2018-06-20 00:00:00
abstract:BACKGROUND:Rehabilitation is crucial for maximizing recovery after stroke. Rehabilitation activities that are fun and rewarding by themselves can be more effective than those who are not. Gamification with virtual reality (VR) exploits this principle. This single-case design study probes the potential for using commerc...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00788-x
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Parkinson's disease is a chronic, neurodegenerative disease characterized by gait abnormalities. Freezing of gait (FOG), an episodic inability to generate effective stepping, is reported as one of the most disabling and distressing parkinsonian symptoms. While there are no specific therapies to treat FOG, so...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-51
更新日期:2010-10-14 00:00:00
abstract:BACKGROUND:Forearm surface electromyography (EMG) has been in use since the Sixties to feed-forward control active hand prostheses in a more and more refined way. Recent research shows that it can be used to control even a dexterous polyarticulate hand prosthesis such as Touch Bionics's i-LIMB, as well as a multifinger...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-6-41
更新日期:2009-11-17 00:00:00
abstract:BACKGROUND:Electrooculogram (EOG) can be used to continuously track eye movements and can thus be considered as an alternative to conventional camera-based eye trackers. Although many EOG-based eye tracking systems have been studied with the ultimate goal of providing a new way of communication for individuals with amy...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-017-0303-5
更新日期:2017-09-08 00:00:00
abstract:BACKGROUND:The study of gait at self-selected speed is important. Traditional gait laboratories being relatively limited in space provide insufficient path length, while treadmill (TM) walking compromises natural gait by imposing speed variables. Self-paced (SP) walking can be realized on TM using feedback-controlled b...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-015-0002-z
更新日期:2015-02-21 00:00:00
abstract::Transcutaneous neuromuscular electrical stimulation applied in clinical settings is currently characterized by a wide heterogeneity of stimulation protocols and modalities. Practitioners usually refer to anatomic charts (often provided with the user manuals of commercially available stimulators) for electrode position...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 社论
doi:10.1186/1743-0003-11-17
更新日期:2014-02-25 00:00:00
abstract:BACKGROUND:Mobile health monitoring using wearable sensors is a growing area of interest. As the world's population ages and locomotor capabilities decrease, the ability to report on a person's mobility activities outside a hospital setting becomes a valuable tool for clinical decision-making and evaluating healthcare ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-016-0114-0
更新日期:2016-01-20 00:00:00
abstract::The inattentive eye often will not notice it, but synchronization among human walking partners is quite common. In this first investigation of this phenomenon, we studied its frequency and the mechanisms that contribute to this form of "entrainment." Specifically, by modifying the available communication links between...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-4-28
更新日期:2007-08-08 00:00:00
abstract:BACKGROUND:After a limb is lost a prosthesis can restore function. For maximum utility, prosthetic limbs should accept movement commands and provide force and motion feedback, which can be conveyed with vibrotactile feedback (VIBF). While prior studies have shown that force-based VIBF benefits control, the merits of mo...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-015-0025-5
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:Prediction of Gait intention from pre-movement Electroencephalography (EEG) signals is a vital step in developing a real-time Brain-computer Interface (BCI) for a proper neuro-rehabilitation system. In that respect, this paper investigates the feasibility of a fully predictive methodology to detect the inten...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00675-5
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Quantitative evaluation of position control ability in stroke patients is needed. Here we report a demonstration of position control ability assessment and test-retest reliability during squat-stand activity on a new system in hemiparetic patients and controls. METHODS:Sixty-two healthy adults and thirty-fo...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-10-37
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:Powered exoskeletons are a promising approach to restore the ability to walk after spinal cord injury (SCI). However, current exoskeletons remain limited in their walking speed and ability to support tasks of daily living, such as stair climbing or overcoming ramps. Moreover, training progress for such advan...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-018-0360-4
更新日期:2018-03-13 00:00:00
abstract:BACKGROUND:When humans perform rhythmic upper and lower limb locomotor-like movements, there is an excitatory effect of upper limb exertion on lower limb muscle recruitment. To investigate potential neural mechanisms for this behavioral observation, we developed computer simulations modeling interlimb neural pathways a...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-59
更新日期:2010-12-10 00:00:00
abstract:BACKGROUND:The restoration of walking ability is the main goal of post-stroke lower limb rehabilitation and different studies suggest that pedaling may have a positive effect on locomotion. The aim of this study was to explore the feasibility of a biofeedback pedaling treatment and its effects on cycling and walking ab...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/1743-0003-8-47
更新日期:2011-08-24 00:00:00
abstract:BACKGROUND:Accurate measurement of physical behaviour is paramount to better understand lifestyle, health, and functioning, particularly in adults with physical disability as they may be at higher risk of sedentary lifestyle and subsequent negative health consequences. This study aimed: 1) to evaluate the criterion val...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-019-0594-9
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:Advances such as targeted muscle reinnervation and pattern recognition control may provide improved control of upper limb myoelectric prostheses, but evaluating user function remains challenging. Virtual environments are cost-effective and immersive tools that are increasingly used to provide practice and ev...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/s12984-018-0402-y
更新日期:2018-09-05 00:00:00
abstract:BACKGROUND:A common goal of persons post-stroke is to regain community ambulation. The plantar flexor muscles play an important role in propulsion generation and swing initiation as previous musculoskeletal simulations have shown. The purpose of this study was to demonstrate that simulation results quantifying changes ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-10-12
更新日期:2013-01-31 00:00:00