Abstract:
:Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present study we investigated the effects of enwrapping the site of end-to-end rat sciatic nerve repair with an equine type III collagen membrane enriched or not with N1E-115 pre-differentiated neural cells. After neurotmesis, the sciatic nerve was repaired by end-to-end suture (End-to-End group), end-to-end suture enwrapped with an equine collagen type III membrane (End-to-EndMemb group); and end-to-end suture enwrapped with an equine collagen type III membrane previously covered with neural cells pre-differentiated in vitro from N1E-115 cells (End-to-EndMembCell group). Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics. After 20 weeks animals were sacrificed and the repaired sciatic nerves were processed for histological and stereological analysis. Results showed that enwrapment of the rapair site with a collagen membrane, with or without neural cell enrichment, did not lead to any significant improvement in most of functional and stereological predictors of nerve regeneration that we have assessed, with the exception of EPT which recovered significantly better after neural cell enriched membrane employment. It can thus be concluded that this particular type of nerve tissue engineering approach has very limited effects on nerve regeneration after sciatic end-to-end nerve reconstruction in the rat.
journal_name
J Neuroeng Rehabiljournal_title
Journal of neuroengineering and rehabilitationauthors
Amado S,Rodrigues JM,Luís AL,Armada-da-Silva PA,Vieira M,Gartner A,Simões MJ,Veloso AP,Fornaro M,Raimondo S,Varejão AS,Geuna S,Maurício ACdoi
10.1186/1743-0003-7-7subject
Has Abstractpub_date
2010-02-11 00:00:00pages
7issn
1743-0003pii
1743-0003-7-7journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Electrooculogram (EOG) can be used to continuously track eye movements and can thus be considered as an alternative to conventional camera-based eye trackers. Although many EOG-based eye tracking systems have been studied with the ultimate goal of providing a new way of communication for individuals with amy...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-017-0303-5
更新日期:2017-09-08 00:00:00
abstract::Exoskeleton technology has made significant advances during the last decade, resulting in a considerable variety of solutions for gait assistance and rehabilitation. The mechanical design of these devices is a crucial aspect that affects the efficiency and effectiveness of their interaction with the user. Recent devel...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,评审
doi:10.1186/s12984-019-0517-9
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Exoskeletons for lower and upper extremities have been introduced in neurorehabilitation because they can guide the patient's limb following its anatomy, covering many degrees of freedom and most of its natural workspace, and allowing the control of the articular joints. The aims of this study were to evalua...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-016-0117-x
更新日期:2016-01-23 00:00:00
abstract:BACKGROUND:To promote early rehabilitation of walking, gait training can start even when patients are on bed rest. Supine stepping in the early phase after injury is proposed to maximise the beneficial effects of gait restoration. In this training paradigm, mechanical loading on the sole of the foot is required to mimi...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-11-159
更新日期:2014-11-28 00:00:00
abstract:BACKGROUND:The importance to restore the hand function following an injury/disease of the nervous system led to the development of novel rehabilitation interventions. Surface electromyography can be used to create a user-driven control of a rehabilitation robot, in which the subject needs to engage actively, by using s...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-016-0172-3
更新日期:2016-08-04 00:00:00
abstract:BACKGROUND:When humans perform rhythmic upper and lower limb locomotor-like movements, there is an excitatory effect of upper limb exertion on lower limb muscle recruitment. To investigate potential neural mechanisms for this behavioral observation, we developed computer simulations modeling interlimb neural pathways a...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-59
更新日期:2010-12-10 00:00:00
abstract::BACKGROUND: Monitoring body kinematics has fundamental relevance in several biological and technical disciplines. In particular the possibility to exactly know the posture may furnish a main aid in rehabilitation topics. In the present work an innovative and unobtrusive garment able to detect the posture and the movem...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-2-8
更新日期:2005-03-02 00:00:00
abstract:BACKGROUND:Uneven ground is a frequently encountered, yet little-studied challenge for individuals with amputation. The absence of control at the prosthetic ankle to facilitate correction for surface inconsistencies, and diminished sensory input from the extremity, add unpredictability to an already complex control pro...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-019-0497-9
更新日期:2019-02-04 00:00:00
abstract:BACKGROUND:Loss of hand function following high level spinal cord injury (SCI) is perceived as a high priority area for rehabilitation. Following discharge, it is often impractical for the specialist care centre to provide ongoing therapy for people living with chronic SCI at home, which can lead to further deteriorati...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/s12984-020-00660-y
更新日期:2020-03-05 00:00:00
abstract:BACKGROUND:There is an increasing trend in using robots for medical purposes. One specific area is rehabilitation. Rehabilitation is one of the non-drug treatments in community health which means the restoration of the abilities to maximize independence. It is a prolonged work and costly labor. On the other hand, by us...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-10-96
更新日期:2013-08-14 00:00:00
abstract::Even though feedback is considered to play an important role in learning how to operate a brain-computer interface (BCI), to date no significant influence of feedback design on BCI-performance has been reported in literature. In this work, we adapt a standard motor-imagery BCI-paradigm to study how BCI-performance is ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-7-34
更新日期:2010-07-27 00:00:00
abstract:BACKGROUND:The use of neurorobotic devices may improve gait recovery by entraining specific brain plasticity mechanisms, which may be a key issue for successful rehabilitation using such approach. We assessed whether the wearable exoskeleton, Ekso™, could get higher gait performance than conventional overground gait tr...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12984-018-0377-8
更新日期:2018-04-25 00:00:00
abstract:BACKGROUND:In this paper, a novel functional near-infrared spectroscopy (fNIRS)-based brain-computer interface (BCI) framework for control of prosthetic legs and rehabilitation of patients suffering from locomotive disorders is presented. METHODS:fNIRS signals are used to initiate and stop the gait cycle, while a nonl...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-018-0346-2
更新日期:2018-02-05 00:00:00
abstract:BACKGROUND:Current guidelines for rehabilitation of arm and hand function after stroke recommend that motor training focus on realistic tasks that require reaching and manipulation and engage the patient intensively, actively, and adaptively. Here, we investigated the feasibility of a novel robotic task-practice system...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1743-0003-8-42
更新日期:2011-08-03 00:00:00
abstract:BACKGROUND:Powered exoskeletons are a promising approach to restore the ability to walk after spinal cord injury (SCI). However, current exoskeletons remain limited in their walking speed and ability to support tasks of daily living, such as stair climbing or overcoming ramps. Moreover, training progress for such advan...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-018-0360-4
更新日期:2018-03-13 00:00:00
abstract:BACKGROUND:The aim of this study was to quantitatively analyze quite standing postural stability of adolescent idiopathic scoliosis (AIS) patients in respect to three sensory systems (visual, vestibular, and somatosensory). METHOD:In this study, we analyzed the anterior-posterior center of pressure (CoP) signal using ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-018-0395-6
更新日期:2018-06-22 00:00:00
abstract::The existing shortage of therapists and caregivers assisting physically disabled individuals at home is expected to increase and become serious problem in the near future. The patient population needing physical rehabilitation of the upper extremity is also constantly increasing. Robotic devices have the potential to ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,评审
doi:10.1186/1743-0003-11-3
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:Functional electrical stimulation (FES) during repetitive practice of everyday tasks can facilitate recovery of upper limb function following stroke. Reduction in impairment is strongly associated with how closely FES assists performance, with advanced iterative learning control (ILC) technology providing pr...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/1743-0003-11-105
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:The study of gait at self-selected speed is important. Traditional gait laboratories being relatively limited in space provide insufficient path length, while treadmill (TM) walking compromises natural gait by imposing speed variables. Self-paced (SP) walking can be realized on TM using feedback-controlled b...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-015-0002-z
更新日期:2015-02-21 00:00:00
abstract:BACKGROUND:Following an amputation, the human postural control system develops neuromuscular adaptations to regain an effective postural control. We investigated the compensatory mechanisms behind these adaptations and how sensorimotor integration is affected after a lower-limb transfemoral amputation. METHODS:Center ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-019-0586-9
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:Locomotor strategies for obstacle circumvention require appropriate postural coordination that depends on sensorimotor integration within the central nervous system. It is not known how these strategies are affected by a stroke. The objective of this study was to contrast postural coordination strategies use...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-017-0265-7
更新日期:2017-06-15 00:00:00
abstract::The inattentive eye often will not notice it, but synchronization among human walking partners is quite common. In this first investigation of this phenomenon, we studied its frequency and the mechanisms that contribute to this form of "entrainment." Specifically, by modifying the available communication links between...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/1743-0003-4-28
更新日期:2007-08-08 00:00:00
abstract:BACKGROUND:Motivation is an important factor in rehabilitation and frequently used as a determinant of rehabilitation outcome. Several factors can influence patient motivation and so improve exercise adherence. This paper presents the design of two robot devices for use in the rehabilitation of upper limb movements, th...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/1743-0003-4-3
更新日期:2007-02-19 00:00:00
abstract:BACKGROUND:After a limb is lost a prosthesis can restore function. For maximum utility, prosthetic limbs should accept movement commands and provide force and motion feedback, which can be conveyed with vibrotactile feedback (VIBF). While prior studies have shown that force-based VIBF benefits control, the merits of mo...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-015-0025-5
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:Cerebellar symptoms are extremely disabling and are common in Multiple Sclerosis (MS) subjects. In this feasibility study, we developed and tested a robot therapy protocol, aimed at the rehabilitation of incoordination in MS subjects. METHODS:Eight subjects with clinically defined MS performed planar reachi...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1186/1743-0003-7-37
更新日期:2010-07-29 00:00:00
abstract:BACKGROUND:Treadmill training, with or without body-weight support (BWSTT), typically involves high step count, faster walking speed, and higher heart-rate intensity than overground walking training. The addition of challenging mobility skill practice may offer increased opportunities to improve walking and balance ski...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12984-018-0442-3
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Robot-assisted gait therapy is increasingly being used in pediatric neurorehabilitation to complement conventional physical therapy. The robotic device applied in this study, the Lokomat (Hocoma AG, Switzerland), uses a position control mode (Guidance Force), where exact positions of the knee and hip joints ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1186/s12984-017-0287-1
更新日期:2017-07-14 00:00:00
abstract:BACKGROUND:Understanding how prostheses are used in everyday life is central to the design, provision and evaluation of prosthetic devices and associated services. This paper reviews the scientific literature on methodologies and technologies that have been used to assess the daily use of both upper- and lower-limb pro...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-020-00711-4
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Mobile health monitoring using wearable sensors is a growing area of interest. As the world's population ages and locomotor capabilities decrease, the ability to report on a person's mobility activities outside a hospital setting becomes a valuable tool for clinical decision-making and evaluating healthcare ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章
doi:10.1186/s12984-016-0114-0
更新日期:2016-01-20 00:00:00
abstract::Loss of physical mobility makes maximal participation in desired activities more difficult and in the worst case fully prevents participation. This paper surveys recent work in assistive technology to improve mobility for persons with a disability, drawing on examples observed during a tour of academic and industrial ...
journal_title:Journal of neuroengineering and rehabilitation
pub_type: 杂志文章,评审
doi:10.1186/1743-0003-9-20
更新日期:2012-04-20 00:00:00