Coronaviruses and Central Nervous System Manifestations.

Abstract:

:SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Khateb M,Bosak N,Muqary M

doi

10.3389/fneur.2020.00715

subject

Has Abstract

pub_date

2020-06-23 00:00:00

pages

715

issn

1664-2295

journal_volume

11

pub_type

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