Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature.


BACKGROUND:Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type of tumor is rare; therefore, the corresponding clinical guidelines, histopathological diagnostic criteria, prognostic factors, and therapeutic regimens have not been established. CASE SUMMARY:This study covers a novel presentation of MNC in a patient and summarizes the clinicopathological characteristics of this type of tumor by using pooled-analysis methods. Morphologically, this tumor type is a series of benign to malignant pedigrees. We establish the following criteria for the classification of micronodular thymic tumors with lymphoid stroma: (1) Tumor cells with moderate-to-severe dysplasia; (2) Tumor cell mitotic figures > 2/10 high-power fields; (3) Appearance of neoplastic necrosis; (4) No terminal deoxynucleotidyl transferase-positive immature T lymphocytes within the tumor; (5) Tumor cells with a Ki-67 index ≥ 10%; and (6) Tumor cells express CD5. Cases that fall into the borders of two categories in terms of morphology are attributed to atypical MNT. It is proposed that the diagnosis of MNT should be established on the diagnostic criteria mentioned above. CONCLUSION:Our diagnostic algorithm can effectively distinguish malignant tumors from benign tumors and provides a potent basis for predicting a prognosis, which offers a practical reference for oncologists and pathologists.


World J Clin Cases


Wang B,Li K,Song QK,Wang XH,Yang L,Zhang HL,Zhong DR




Has Abstract


2019-12-06 00:00:00










  • Association between resting energy expenditure, psychopathology and HPA-axis in eating disorders.

    abstract:AIM:To investigate the complex relationships between resting energy expenditure (REE), eating psychopathology, and Hypothalamus Pituitary Adrenal axis functioning in patients with eating disorders. METHODS:The study was designed as a cross-sectional survey, and it was planned by the Clinic for Eating Disorders of the ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Castellini G,Castellani W,Lelli L,Sauro CL,Dini C,Lazzeretti L,Bencini L,Mannucci E,Ricca V

    更新日期:2014-07-16 00:00:00

  • Prosthodontic management of hemimandibulectomy patients to restore form and function - A case series.

    abstract::Surgical resection of mandible owing to benign, malignant neoplasm, osteoradionecrosis is common. The resection can be total or segmental depending on the lesion. Loss of mandibular continuity causes deviation of remaining mandibular segment towards the resected side and rotation inferiorly due to muscle pull and scar...

    journal_title:World journal of clinical cases



    authors: Lingeshwar D,Appadurai R,Sswedheni U,Padmaja C

    更新日期:2017-10-16 00:00:00

  • Premonitory urges located in the tongue for tic disorder: Two case reports and review of literature.

    abstract:BACKGROUND:Premonitory urges (PUs) was defined as the uncomfortable physical sensations of inner tension that can be relieved by producing movement responses. Nearly 70%-90% patients with Tourette syndrome reported experiences of PUs. CASE SUMMARY:In this paper, we present two cases of young patients with PUs located ...

    journal_title:World journal of clinical cases



    authors: Li Y,Zhang JS,Wen F,Lu XY,Yan CM,Wang F,Cui YH

    更新日期:2019-06-26 00:00:00

  • Retrograde jejunogastric intussusception following Braun's jejunojejunostomy.

    abstract::Jejunogastric intussusception is a rare long term complication of Billroth II gastrectomy. The case reported here is a 50 year old man with history of a Billroth II gastrectomy and Braun's side-to-side jejunojejunal anastomosis who presented with hematemesis. On abdominal examination, there was a mass in the left ilia...

    journal_title:World journal of clinical cases



    authors: Gopal R,Elamurugan TP,Hage S,Muthukumarassamy R,Kate V

    更新日期:2014-01-16 00:00:00

  • Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography evaluation of subcutaneous panniculitis-like T cell lymphoma and treatment response.

    abstract::Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a very rare variant of non-Hodgkin's lymphoma. Currently, there is no standard imaging method for staging of SPTCL nor for assessment of treatment response. Here, we describe our use of fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed ...

    journal_title:World journal of clinical cases



    authors: Gorodetskiy VR,Mukhortova OV,Aslanidis IP,Klapper W,Probatova NA

    更新日期:2016-09-16 00:00:00

  • Sustained complete response to erlotinib in squamous cell carcinoma of the head and neck: A case report.

    abstract:BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is the fifth most common cancer worldwide. Inhibition of epidermal growth factor receptor signaling has been shown to be a critical component of therapeutic option. Herein, we report a case of durable complete response to erlotinib. CASE SUMMARY:An 81-year-ol...

    journal_title:World journal of clinical cases



    authors: Thinn MM,Hsueh CT,Hsueh CT

    更新日期:2019-03-06 00:00:00

  • Health care associated infections, antibiotic resistance and clinical outcome: A surveillance study from Sanandaj, Iran.

    abstract:AIM:To study the antibiotic susceptibility patterns of gram-negative healthcare associated bacterial infections at two tertiary hospitals in the Sanandaj city, Kurdistan Province, Iran. METHODS:From January 2012 to December 2012, all positive cultures from potentially sterile body fluids were gathered. They sent to pr...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Soltani J,Poorabbas B,Miri N,Mardaneh J

    更新日期:2016-03-16 00:00:00

  • Prognostic role of alpha-fetoprotein response after hepatocellular carcinoma resection.

    abstract:AIM:To investigate whether the change in pre-/post-operation serum alpha-fetoprotein (AFP) levels is a predictive factor for hepatocellular carcinoma (HCC) outcomes. METHODS:We retrospectively analyzed 334 HCC patients who underwent hepatic resection at our hospital between January 2006 and December 2016. The patients...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Rungsakulkij N,Suragul W,Mingphruedhi S,Tangtawee P,Muangkaew P,Aeesoa S

    更新日期:2018-06-16 00:00:00

  • Fracture of the scapular neck combined with rotator cuff tear: A case report.

    abstract:BACKGROUND:Scapular fracture has a low incidence rate, accounting for 0.4%-0.9% of all fractures, and scapular neck fractures are extremely rare, comprising approximately 7%-25% of all scapular fractures. Scapular neck fractures are often studied as case reports mostly accompanied by other injuries, thus leading to con...

    journal_title:World journal of clinical cases



    authors: Chen L,Liu CL,Wu P

    更新日期:2020-12-26 00:00:00

  • Association between liver targeted antiviral therapy in colorectal cancer and survival benefits: An appraisal.

    abstract::In colorectal cancer (CRC), liver metastasis remains a major contributor to the cause of cancer-related death. Putative biomarkers, therapeutic efficacy, and drug insensitivity still pose clinical challenges for metastatic CRC patients. Interestingly, previous studies indicated that tumor cells in CRC did not metastas...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Wang Q,Yu CR

    更新日期:2020-06-06 00:00:00

  • A large basal cell adenoma extending to the ipsilateral skull base and mastoid in the right parotid gland: A case report.

    abstract:BACKGROUND:Basal cell adenoma (BCA) is a rare benign tumour that has unique histological characteristics and primarily arises in the parotid glands. According to published reports, nearby tissue destruction by BCA seems impossible. CASE SUMMARY:We presented a case of a 54-year-old woman with a mass in the deep lobe of...

    journal_title:World journal of clinical cases



    authors: Du LY,Weng XH,Shen ZY,Cheng B

    更新日期:2019-06-06 00:00:00

  • Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding - ovulation dysfunction patients.

    abstract:BACKGROUND:Dydrogesterone has shown significant efficacy in treatment of irregular menstrual cycle due to abnormal uterine bleeding - ovulation dysfunction (AUB-O), but there were few relevant studies. This observational study was designed to evaluate the effectiveness of dydrogesterone for the treatment of Chinese pat...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Wang L,Guan HY,Xia HX,Chen XY,Zhang W

    更新日期:2020-08-06 00:00:00

  • Nutritional deficiencies in the pediatric age group in a multicultural developed country, Israel.

    abstract::Nutrient deficiencies are prevalent worldwide. Diseases and morbid conditions have been described to result from nutritional deficiencies. It is essential to address nutrient deficiencies as these may lead to chronic long-term health problems such as rickets, iron deficiency anemia, goiter, obesity, coronary heart dis...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Haimi M,Lerner A

    更新日期:2014-05-16 00:00:00

  • Late-onset non-islet cell tumor hypoglycemia: A case report.

    abstract:BACKGROUND:Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia (NICTH). As NICTH is a rare lesion, the natural course of NICTH is not well understood. We report a case of NICTH that was observed 30 years before the onset of hypoglycemia. CASE SUMMARY:A 50-year-old man w...

    journal_title:World journal of clinical cases



    authors: Matsumoto S,Yamada E,Nakajima Y,Yamaguchi N,Okamura T,Yajima T,Yoshino S,Horiguchi K,Ishida E,Yoshikawa M,Nagaoka J,Sekiguchi S,Sue M,Okada S,Fukuda I,Shirabe K,Yamada M

    更新日期:2021-01-06 00:00:00

  • Marjolin's ulcers in the post-burned lesions and scars.

    abstract::Marjolin's ulcer (MU) represents malignant degeneration that typically ensues over a period of time in the post-burned lesions and scars or any other chronic wound. This review highlights various facets of the presentation and management of MUs that originate from post-burned lesions. The incidence of MUs in such lesi...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Saaiq M,Ashraf B

    更新日期:2014-10-16 00:00:00

  • Transanal minimally invasive surgery vs endoscopic mucosal resection for rectal benign tumors and rectal carcinoids: A retrospective analysis.

    abstract:BACKGROUND:Transanal minimally invasive surgery (TAMIS) is a good choice for resection of rectal neoplasms. Endoscopic mucosal resection (EMR) is also widely used in the treatment of benign rectal tumors such as rectal polyps and rectal adenomas. However, no studies have compared the outcome of TAMIS and EMR. AIM:To c...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Shen JM,Zhao JY,Ye T,Gong LF,Wang HP,Chen WJ,Cai YK

    更新日期:2020-10-06 00:00:00

  • Elusive left ventricular thrombus: Diagnostic role of cardiac magnetic resonance imaging-A case report and review of the literature.

    abstract::Identification of left ventricular mural thrombus (LVT) may be challenging depending on the imaging modality used. We present a case of LVT which was incidentally identified on cine cardiac magnetic resonance imaging (CMR). A sixty-four years old female presented with worsening dyspnea on exertion with troponin elevat...

    journal_title:World journal of clinical cases



    authors: Siddiqui I,Nguyen T,Movahed A,Kabirdas D

    更新日期:2018-06-16 00:00:00

  • Small-cell neuroendocrine carcinoma of the rectum - a rare tumor type with poor prognosis: A case report and review of literature.

    abstract:BACKGROUND:Small-cell neuroendocrine carcinoma (SNEC) of the rectum is a rare tumor associated with poor prognosis. CASE SUMMARY:We report a case of a 77-year-old male who came into our hospital because of blood with his stool. An endoscopy revealed a cauliflower-like neoplasm in his rectum. Imaging examination showed...

    journal_title:World journal of clinical cases



    authors: Chen ZZ,Huang W,Wei ZQ

    更新日期:2020-12-06 00:00:00

  • Inverse correlation between CD8+ inflammatory cells and E-cadherin expression in gallbladder cancer: Tissue microarray and imaging analysis.

    abstract:AIM:To investigated the association between the tumor cells' expression of E-cadherin and the numbers of several types of inflammatory cells infiltrating into the invasive portion of gallbladder cancer (GBC). METHODS:We analyzed 50 GBC cases for which a sufficient amount of tumor tissues for tissue microarray (TMA) ha...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Kai K,Masuda M,Aishima S

    更新日期:2017-01-16 00:00:00

  • Clinical outcomes for Conduits and Scaffolds in peripheral nerve repair.

    abstract::The gold standard of peripheral nerve repair is nerve autograft when tensionless repair is not possible. Use of nerve autograft has several shortcomings, however. These include limited availability of donor tissue, sacrifice of a functional nerve, and possible neuroma formation. In order to address these deficiencies,...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Gerth DJ,Tashiro J,Thaller SR

    更新日期:2015-02-16 00:00:00

  • Mediastinal small cell carcinoma with liver and bone marrow metastasis, mimicking lymphoma.

    abstract::Primary mediastinal neuroendocrine tumors are a rare malignancy that accounts for < 10% of all mediastinal tumors. The case presented here involves a 52-year-old man who had been suffering for 3 mo from chronic cough, anorexia and substantial weight loss, as well as 2 wk of jaundice prior to his admission. A computed ...

    journal_title:World journal of clinical cases



    authors: Nawarawong N,Pongpruttipan T,Aswakul P,Prachayakul V

    更新日期:2015-10-16 00:00:00

  • Dysbetalipoproteinemia: Two cases report and a diagnostic algorithm.

    abstract::Dysbetalipoproteinemia is a rare familial dyslipidemia characterized by approximately equally elevated serum cholesterol and triglyceride levels due to accumulated remnant lipoproteins in apolipoprotein E2/E2 homozygotes. It is associated with an increased risk for premature cardiovascular disease. Thus, making a diag...

    journal_title:World journal of clinical cases



    authors: Kei A,Miltiadous G,Bairaktari E,Hadjivassiliou M,Cariolou M,Elisaf M

    更新日期:2015-04-16 00:00:00

  • Colovesical fistula caused by glucocorticoid therapy for IgG4-related intrapelvic mass.

    abstract::IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid co...

    journal_title:World journal of clinical cases



    authors: Yabuuchi Y,Matsubayashi H,Matsuzaki M,Shiomi A,Moriguchi M,Kawamura I,Ito I,Ono H

    更新日期:2015-12-16 00:00:00

  • Promising new treatment targets in patients with fibrosing lung disorders.

    abstract::The processes of lung fibrogenesis and fibrotic healing are common to a number of conditions with different etiologies. The lungs are the only affected organ in some cases, whereas in others, several organ systems are involved. Therapeutic options can be discussed from various perspectives. In this review, we address ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Sterclova M,Vasakova M

    更新日期:2014-11-16 00:00:00

  • Clinical and diagnostic aspects of gluten related disorders.

    abstract::Gluten is one of the most abundant and widely distributed components of food in many areas. It can be included in wheat, barley, rye, and grains such as oats, barley, spelt, kamut, and triticale. Gluten-containing grains are widely consumed; in particular, wheat is one of the world's primary sources of food, providing...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Tovoli F,Masi C,Guidetti E,Negrini G,Paterini P,Bolondi L

    更新日期:2015-03-16 00:00:00

  • Relationship between homocysteine level and prognosis of elderly patients with acute ischemic stroke treated by thrombolysis with recombinant tissue plasminogen activator.

    abstract:BACKGROUND:Acute ischemic stroke (AIS) is mainly caused by cerebral blood flow disorders, which further leads to ischemic brain necrosis or encephalomalacia. The role of homocysteine (Hcy), an independent risk factor for cardiovascular disease, in the development of atherosclerosis is gradually revealed. However, studi...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Li J,Zhou F,Wu FX

    更新日期:2019-11-26 00:00:00

  • Type A aortic dissection developed after type B dissection with the presentation of shoulder pain: A case report.

    abstract:BACKGROUND:Aortic dissection (AD) is a life-threatening condition with a high mortality rate without immediate medical attention. Early diagnosis and appropriate treatment are critical in treating patients with AD. In the emergency department, patients with AD commonly present with classic symptoms of unanticipated sev...

    journal_title:World journal of clinical cases



    authors: Yin XB,Wang XK,Xu S,He CY

    更新日期:2021-01-06 00:00:00

  • Healthy neonate born to a SARS-CoV-2 infected woman: A case report and review of literature.

    abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus that has generated a worldwide outbreak of infections. Many people with coronavirus disease-2019 (COVID-19) have developed severe illness, and a significant number have died. However, little is known regarding infe...

    journal_title:World journal of clinical cases



    authors: Wang RY,Zheng KQ,Xu BZ,Zhang W,Si JG,Xu CY,Chen H,Xu ZY,Wu XM

    更新日期:2020-12-06 00:00:00

  • Cardiovascular impact of COVID-19 with a focus on children: A systematic review.

    abstract:BACKGROUND:Since the beginning of the pandemic, coronavirus disease-2019 (COVID-19) in children has shown milder cases and a better prognosis than adults. Although the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cardiovascular involvement is emerging as one ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Rodriguez-Gonzalez M,Castellano-Martinez A,Cascales-Poyatos HM,Perez-Reviriego AA

    更新日期:2020-11-06 00:00:00

  • Influencing factors of postoperative early delayed gastric emptying after minimally invasive Ivor-Lewis esophagectomy.

    abstract:BACKGROUND:The main clinical treatment for esophageal cancer is surgery. Since traditional open esophageal cancer resection has the disadvantages of large trauma, long recovery period, and high postoperative complication rate, its clinical application is gradually reduced. The current report of minimally invasive Ivor-...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Huang L,Wu JQ,Han B,Wen Z,Chen PR,Sun XK,Guo XD,Zhao CM

    更新日期:2019-02-06 00:00:00