Abstract:
BACKGROUND:Waldenström macroglobulinemia (WM) is a type of small lymphocytic lymphoma that mainly affects the bone marrow, spleen, and lymph nodes. A subset of patients with WM demonstrates extramedullary involvement (4.4%), and the most frequent extramedullary disease site involved is the lungs (30%). CASE SUMMARY:A 60-year-old male patient who experienced intermittent breath-holding for 6 mo was admitted on August 14, 2017. Chest computed tomography indicated multiple pulmonary cavities in the upper lobes of both lungs, with pulmonary consolidation, ground-glass opacities, patchy infiltrates, fibrous bands, large bullae, and enlarged lymph nodes in the mediastinum. The patient was a heavy smoker (20 cigarettes/d for 40 years). Diagnostic fiberoptic bronchoscopy revealed normal findings. Serological examination revealed a remarkable increase in serum immunoglobulin M levels (30.24 g/L; normal: 0.4-2.30 g/L). A computed tomography-guided percutaneous pulmonary biopsy was performed in the left lower lobe of the lung with pulmonary consolidation and indicated that the alveolar structure disappeared and that a large amount of amyloid-like deposition was present along with the infiltration of very few lymphocytes and plasma cells. The patient was treated with the combined treatment of dexamethasone + rituximab + lenalidomide over four courses. Serum immunoglobulin M did not normalize, and he received ibrutinib + dexamethasone. CONCLUSION:This patient with WM and lung amyloidosis had a wide range of pulmonary lesions and a variety of morphological features, which was a rare case. Yet, some changes might be ascribed to heavy smoking.
journal_name
World J Clin Casesjournal_title
World journal of clinical casesauthors
Zhao DF,Ning HY,Cen J,Liu Y,Qian LR,Han ZH,Shen JLdoi
10.12998/wjcc.v8.i11.2305subject
Has Abstractpub_date
2020-06-06 00:00:00pages
2305-2311issue
11issn
2307-8960journal_volume
8pub_type
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journal_title:World journal of clinical cases
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journal_title:World journal of clinical cases
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journal_title:World journal of clinical cases
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journal_title:World journal of clinical cases
pub_type: 杂志文章
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更新日期:2019-07-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i21.5139
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v2.i10.507
更新日期:2014-10-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i15.1986
更新日期:2019-08-06 00:00:00
abstract:BACKGROUND:The most important factors affecting the decision of organ donation are socioeconomic, educational, cultural, and religious factors. AIM:To evaluate Islamic religious officials' attitudes and behaviors toward and level of knowledge on organ donation and transplantation. METHODS:This study surveyed 2350 Isl...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i9.1620
更新日期:2020-05-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2020-11-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i18.4207
更新日期:2020-09-26 00:00:00
abstract::Targeted drug delivery to solid tumors is a very active research area, focusing mainly on improved drug formulation and associated best delivery methods/devices. Drug-targeting has the potential to greatly improve drug-delivery efficacy, reduce side effects, and lower the treatment costs. However, the vast majority of...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v2.i12.742
更新日期:2014-12-16 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2015-11-16 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2019-10-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2019-11-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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journal_title:World journal of clinical cases
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更新日期:2015-08-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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更新日期:2015-03-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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更新日期:2015-06-16 00:00:00