The Efficacy and Evidence-Based Use of Biologics in Children and Adolescents: Using Monoclonal Antibodies and Fusion Proteins as Treatments.

abstract：BACKGROUND:25% of all women report involuntary loss of urine, and 7% may require treatment. METHODS:This review is based on a selection of pertinent literature, including guidelines and Cochrane reviews. RESULTS:The assessment of pelvic floor dysfunction in women begins with a basic evaluation that is followed by spe...

journal_title：Deutsches Arzteblatt international

authors： Jundt K,Peschers U,Kentenich H

更新日期：2015-08-17 00:00:00

abstract：BACKGROUND:The risk of venous thromboembolism (VTE) is 4 to 7 times higher in cancer patients than in the normal population. Moreover, cancer patients who take anticoagulants suffer more frequently from hemorrhagic complications and VTE recurrences. Patients often find low-molecular-weight heparin (LMWH) treatment unpl...

journal_title：Deutsches Arzteblatt international

authors： Beyer-Westendorf J,Klamroth R,Kreher S,Langer F,Matzdorff A,Riess H

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system. There are at least 150 000 persons with MS in Germany. Recent years have seen the approval of new drugs against. METHODS:This article is based on pertinent literature retrieved by a selective search in PubMed as wel...

journal_title：Deutsches Arzteblatt international

authors： Havla J,Warnke C,Derfuss T,Kappos L,Hartung HP,Hohlfeld R

更新日期：2016-12-26 00:00:00

abstract：BACKGROUND:When gunshot and blast injuries affect only a single person, first aid can always be delivered in conformity with the relevant guidelines. In contrast, when there is a dynamic casualty situation affecting many persons, such as after a terrorist attack, treatment may need to be focused on immediately life-thr...

journal_title：Deutsches Arzteblatt international

authors： Franke A,Bieler D,Friemert B,Schwab R,Kollig E,Güsgen C

更新日期：2017-04-07 00:00:00

abstract：INTRODUCTION:Many psychotropic drugs can delay cardiac repolarization and thereby prolong the rate-corrected QT interval (QTc). A prolonged QTc often arouses concern in clinical practice, as it can be followed, in rare cases, by the life-threatening polymorphic ventricular tachyarrhythmia called torsade de pointes (TdP...

journal_title：Deutsches Arzteblatt international

authors： Wenzel-Seifert K,Wittmann M,Haen E

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:4-10% of the general population and 20% of primary care patients have what are called "non-specific, functional, and somatoform bodily complaints." These often take a chronic course, markedly impair the sufferers' quality of life, and give rise to high costs. They can be made worse by inappropriate behavior ...

journal_title：Deutsches Arzteblatt international

authors： Schaefert R,Hausteiner-Wiehle C,Häuser W,Ronel J,Herrmann M,Henningsen P

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer in women. The German S3 guideline of 2012 has now been updated to take account of advances in the early detection, diagnostic evaluation, treatment, and follow-up care of this disease. METHODS:The updating process was based on the adaptation of identified source guide...

journal_title：Deutsches Arzteblatt international

authors： Wöckel A,Albert US,Janni W,Scharl A,Kreienberg R,Stüber T

更新日期：2018-05-04 00:00:00

abstract：INTRODUCTION:A confusing variety of options are available for the treatment of depressive disorders. METHOD:Selective literature review under consideration of current guidelines. RESULTS:The treatment of depression can be divided into acute, maintenance and prophylactic phases. The basic forms of treatment are pharma...

journal_title：Deutsches Arzteblatt international

authors： Bschor T,Adli M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Systematic reviews provide a structured summary of the results of trials that have been carried out on any particular subject. If the data from multiple trials are sufficiently homogenous, a meta-analysis can be performed to calculate pooled effect estimates. Traditional meta-analysis involves groups of tria...

journal_title：Deutsches Arzteblatt international

authors： Kiefer C,Sturtz S,Bender R

更新日期：2015-11-20 00:00:00

abstract：BACKGROUND:Nail disorders can arise at any age. About half of all nail disorders are of infectious origin, 15% are due to inflammatory or metabolic conditions, and 5% are due to malignancies and pigment disturbances. The differential diagnosis of nail disorders is often an area of uncertainty. METHODS:This review is b...

journal_title：Deutsches Arzteblatt international

authors： Wollina U,Nenoff P,Haroske G,Haenssle HA

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Most women of child-bearing age want a safe method of contraception. Numerous methods are available, with different modes of application. In situations involving particular risks, the selection of the right method poses a special challenge. METHODS:Contraceptive methods for use in various situations with in...

journal_title：Deutsches Arzteblatt international

authors： Römer T

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:The prevalence of abdominal aortic aneurysms (AAA) with a maximal diameter of 3 cm or more is age-dependent; among persons over age 65, it lies between 4% and 8% in men and between 0.5% and 1.5% in women. About 10% of all AAAs have a maximum diameter of 5 cm or more. The prognosis of ruptured AAA (rAAA) is d...

journal_title：Deutsches Arzteblatt international

authors： Eckstein HH,Böckler D,Flessenkämper I,Schmitz-Rixen T,Debus S,Lang W

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Basically two types of sweating exist: thermoregulatory and emotional sweating. They are controlled by different centers: thermo regulatory sweating is regulated predominantly by the hypothalamus, emotional sweating predominantly by the limbic system. Enhanced sweating, called hyperhidrosis, can be generaliz...

journal_title：Deutsches Arzteblatt international

authors： Schlereth T,Dieterich M,Birklein F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Scoliosis is a three-dimensional deviation of the spinal axis. The main diagnostic criterion is spinal curvature exceeding 10° on a plain anteroposterior X-ray image. Scoliosis is called idiopathic when no other underlying disease can be identified. METHODS:Selective literature review and recommendations of...

journal_title：Deutsches Arzteblatt international

authors： Trobisch P,Suess O,Schwab F

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:In view of the rise in antibiotic resistance and Clostridium difficile superinfection, close monitoring of antibiotic prescribing practices is essential so that targeted quality assurance measures can be taken. METHODS:We analyzed nationwide data from multiple statutory health insurance carriers on prescrip...

journal_title：Deutsches Arzteblatt international

authors： Bätzing-Feigenbaum J,Schulz M,Schulz M,Hering R,Kern WV

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The randomized, controlled trial (RCT) is the gold standard of scientific evidence for the attribution of clinical effects (benefits and harms) to medical interventions. Many different designs for RCTs have been developed in order to counter legitimate critical objections and to better adapt the trials to th...

journal_title：Deutsches Arzteblatt international

authors： Lange S,Sauerland S,Lauterberg J,Windeler J

更新日期：2017-09-22 00:00:00

abstract：BACKGROUND:An estimated 1.4 to 2.6 million people in German suffer from drug dependence. Most of them are long-term users of benzodiazepines (BZD), Z drugs (ZD), or opioid analgesics (OA). METHODS:This analysis is based on prescription data from patients of the national statutory health insurance system in the German ...

journal_title：Deutsches Arzteblatt international

authors： Buth S,Holzbach R,Martens MS,Neumann-Runde E,Meiners O,Verthein U

更新日期：2019-09-13 00:00:00

abstract：BACKGROUND:The German Federal Law on Radiation Control contains no special provisions for X-ray studies in children and adolescents, even though exposure to ionizing radiation must be kept especially low in young persons, because their tissues are highly radiosensitive. Children, who have many years left to live, are m...

journal_title：Deutsches Arzteblatt international

authors： Alzen G,Benz-Bohm G

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:One-third of all patients with epilepsy have persistent seizures despite medical treatment. If the origin of the seizures can be localized to a particular site in the brain, epilepsy surgery is a treatment option that addresses the cause of the problem. METHOD:The presurgical assessment and surgical treatme...

journal_title：Deutsches Arzteblatt international

authors： Schulze-Bonhage A,Zentner J

更新日期：2014-05-02 00:00:00

abstract：BACKGROUND:In Germany, rehabilitation is considered to be indicated after an acute hospital stay for the treatment of a severe cardiac condition. In comparative studies, at least 51% of German hospital patients with coronary heart disease (CHD) who were entitled to rehabilitative measures actually took part n rehabilit...

journal_title：Deutsches Arzteblatt international

authors： Schlitt A,Wischmann P,Wienke A,Hoepfner F,Noack F,Silber RE,Werdan K

更新日期：2015-08-03 00:00:00

abstract：:[This corrects the article DOI: 10.3238/arztebl.2017.0661.]. ...

journal_title：Deutsches Arzteblatt international

authors：

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The long-term use of opioid analgesic drugs to treat chronic non-cancer pain (CNCP) is a major component of pain pharmacotherapy. The interpretation of the evidence concerning its efficacy and risks is currently debated. METHODS:An interdisciplinary evidence- and consensus-based S3 guideline was updated on ...

journal_title：Deutsches Arzteblatt international

authors： Häuser W,Bock F,Engeser P,Tölle T,Willweber-Strumpfe A,Petzke F

更新日期：2014-10-24 00:00:00

abstract：BACKGROUND:Urinary tract infections (UTI) are among the leading reasons for treatment in adult primary care medicine, accounting for a considerable percentage of antibiotic prescriptions. Because this problem is so common and so significant in routine clinical practice, a high level of diagnostic accuracy is essential....

journal_title：Deutsches Arzteblatt international

authors： Schmiemann G,Kniehl E,Gebhardt K,Matejczyk MM,Hummers-Pradier E

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:5% to 8% of 70-year-olds and some 10% of persons over age 80 have atrial fibrillation (AF). METHODS:Selective literature review. RESULTS:New scoring schemes (CHA(2)DS(2)-VASc score, HAS-BLED score) have been introduced to enable more accurate estimation of the risk of stroke and hemorrhage in patients with...

journal_title：Deutsches Arzteblatt international

authors： Trappe HJ

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Lung cancer is the leading cause of death from cancer in Germany. 90% of cases are due to the inhalation of tobacco smoke. About 40% of patients with newly diagnosed lung cancer are still smokers. A structured smoking cessation program is medically reasonable in this situation but is only rarely offered. ME...

journal_title：Deutsches Arzteblatt international

authors： Andreas S,Rittmeyer A,Hinterthaner M,Huber RM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:For prospective parents at risk of transmitting a monogenic disease, polar body analysis is an option for pre-conception genetic diagnosis. In Germany, polar body analysis is currently performed in only two centers (Lübeck and Regensburg). METHODS:The authors present a clinical series of 9 couples at risk f...

journal_title：Deutsches Arzteblatt international

authors： Griesinger G,Bündgen N,Salmen D,Schwinger E,Gillessen-Kaesbach G,Diedrich K

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Autopsy studies of persons who died of cancer have shown the lungs to be the sole site of metastasis in about 20% of cases. The resection of pulmonary metastases is indicated for palliative purposes if they contain a large volume of necrotic tumor, infiltrate the thoracic wall to produce pain, or cause hem...

journal_title：Deutsches Arzteblatt international

authors： Pfannschmidt J,Egerer G,Bischof M,Thomas M,Dienemann H

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Overweight and obesity are generally thought to elevate morbidity and mortality. New data call this supposed association into question. METHODS:The Cochrane, Pubmed, and other databases were systematically searched for a combination of relevant terms and subject headings. Meta-analyses and cohort studies ba...

journal_title：Deutsches Arzteblatt international

authors： Lenz M,Richter T,Mühlhauser I

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infections are becoming more common, more severe, and more likely to recur. Conventional treatment with antibiotics often fails to eradicate the infection; even when it succeeds, recurrent infection is common. Complementary treatment with probiotic agents to reconstitute the physiologic...

journal_title：Deutsches Arzteblatt international

authors： Kleger A,Schnell J,Essig A,Wagner M,Bommer M,Seufferlein T,Härter G

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:About 17% of all children suffer from a mental disorder in early childhood, defined as the period up to the age of 6 years. METHODS:This review is based on publications retrieved by a selective search in PubMed and the Web of Science, as well as on the authors' clinical and scientific experience. RESULTS:I...

journal_title：Deutsches Arzteblatt international

authors： von Klitzing K,Döhnert M,Kroll M,Grube M

更新日期：2015-05-25 00:00:00