QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes.

abstract：BACKGROUND:Dear Doctor Letters (also known as Direct Healthcare Professional Communications) inform physicians about significant newly discovered drug risks and about measures to take to reduce these risks. How far these warnings actually influence prescribing behavior is unclear. METHOD:The Geriatrics in Bavaria-Data...

journal_title：Deutsches Arzteblatt international

authors： Schächtele S,Tümena T,Gaßmann KG,Fromm MF,Maas R

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Habitually shortened nighttime sleep is a common phenomenon in childhood and adolescence, sometimes associated with chronic sleep reduction (CSR). CSR is associated with impairments of performance ability and emotional well-being. The extent to which children and adolescents in Germany suffer from CSR is unc...

journal_title：Deutsches Arzteblatt international

authors： Paschke K,Laurenz L,Thomasius R

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Many patients in German hospitals complain of inadequate treatment of their postoperative pain. Hospital-related structural and procedural variables may affect pain perception and patient satisfaction. We studied the association of individual variables with outcome quality. METHODS:Data from the years 2011 ...

journal_title：Deutsches Arzteblatt international

authors： Meißner W,Komann M,Erlenwein J,Stamer U,Scherag A

更新日期：2017-03-10 00:00:00

abstract：BACKGROUND:The many varieties of cystic pancreatic tumor, and especially intraductal papillary mucinous neoplasia (IPMN), have attracted increased attention recently. Their incidence may be rising, and their histopathological evaluation and classification have become more precise than before. METHODS:We discuss the cu...

journal_title：Deutsches Arzteblatt international

authors： Grützmann R,Post S,Saeger HD,Niedergethmann M

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:In this study, we investigated the measures currently being taken in German hospitals to prevent infection with methicillin-resistant strains of Staphylococcus aureus (MRSA). To this end, we circulated a questionnaire among hospitals participating in the MRSA-KISS module. "KISS" in the name of this project s...

journal_title：Deutsches Arzteblatt international

authors： Chaberny IF,Wriggers A,Behnke M,Gastmeier P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Because the course of Legg-Calvé-Perthes disease (LCPD) is highly variable, its appropriate diagnostic evaluation and treatment are still debated. METHODS:The authors selectively review the literature, present their own study findings, and discuss the guidelines of the German Society for Orthopedics and Ort...

journal_title：Deutsches Arzteblatt international

authors： Nelitz M,Lippacher S,Krauspe R,Reichel H

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Multi-center observational studies in surgery can yield important findings, as long as they are appropriately designed and monitored and employ modern methods of statistical analysis. METHODS:In a multi-center quality assurance study carried out in 346 German hospitals from 2000 to 2004, data were collected...

journal_title：Deutsches Arzteblatt international

authors： Kube R,Gastinger I,Mroczkowski P,Ptok H,Wolff S,Lippert H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The neuropsychiatric symptoms of dementia, including aggressiveness, agitation, depression, and apathy are often treated with psychotropic drugs and are a frequent reason for hospitalization, placing an economic burden on the health care system. International guidelines recommend syndrome-specific pharmacoth...

journal_title：Deutsches Arzteblatt international

authors： Majic T,Pluta JP,Mell T,Aichberger MC,Treusch Y,Gutzmann H,Heinz A,Rapp MA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The German Federal Law on Radiation Control contains no special provisions for X-ray studies in children and adolescents, even though exposure to ionizing radiation must be kept especially low in young persons, because their tissues are highly radiosensitive. Children, who have many years left to live, are m...

journal_title：Deutsches Arzteblatt international

authors： Alzen G,Benz-Bohm G

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:When reading reports of medical research findings, one is usually confronted with p-values. Publications typically contain not just one p-value, but an abundance of them, mostly accompanied by the word "significant." This article is intended to help readers understand the problem of multiple p-values and how...

journal_title：Deutsches Arzteblatt international

authors： Victor A,Elsässer A,Hommel G,Blettner M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The prevalence of latent/subclinical hypothyroidism is between 3% and 10%, according to epidemiologic studies that have been carried out in the USA, the United Kingdom, and Denmark. As persons with latent hypo - thyroidism are often asymptomatic, the diagnosis is often made incidentally in routine laboratory...

journal_title：Deutsches Arzteblatt international

authors： Schübel J,Feldkamp J,Bergmann A,Drossard W,Voigt K

更新日期：2017-06-23 00:00:00

abstract：BACKGROUND:5% to 8% of 70-year-olds and some 10% of persons over age 80 have atrial fibrillation (AF). METHODS:Selective literature review. RESULTS:New scoring schemes (CHA(2)DS(2)-VASc score, HAS-BLED score) have been introduced to enable more accurate estimation of the risk of stroke and hemorrhage in patients with...

journal_title：Deutsches Arzteblatt international

authors： Trappe HJ

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Military missions abroad carry a high risk of psychological traumatization. In this study, we examined the reasons for increased utilization of the treatments offered to soldiers by the German armed forces' psychiatric services. METHOD:We analyzed trends in initial contacts with psychiatrists and psychoth...

journal_title：Deutsches Arzteblatt international

authors： Kowalski JT,Hauffa R,Jacobs H,Höllmer H,Gerber WD,Zimmermann P

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend psychosocial care as an integral part of medical treatment, but access is often limited. Technology-based approaches provide an attractive opportunity to optimize health outcomes and quality of life in people with chronic somatic diseases e.g. by means of Internet- and mobile-ba...

journal_title：Deutsches Arzteblatt international

authors： Bendig E,Bauereiß N,Ebert DD,Snoek F,Andersson G,Baumeister H

更新日期：2018-11-05 00:00:00

abstract：BACKGROUND:Adverse drug events (ADE) are a common cause of hospital admission as well as a common complication of inpatient care. The current reporting systems in Germany are of only limited use for the identification of ADE. The aim of this study is to examine the potential usefulness of ICD-10 coded diagnoses in rout...

journal_title：Deutsches Arzteblatt international

authors： Stausberg J,Hasford J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Few reliable data are available on the epidemiology and treatment of spontaneous pneumothorax. We studied the sex and age distribution, frequency of hospitalization, mortality, and conservative versus surgical care of this condition in Germany in order to draw well-founded conclusions about its in-hospital d...

journal_title：Deutsches Arzteblatt international

authors： Schnell J,Koryllos A,Lopez-Pastorini A,Lefering R,Stoelben E

更新日期：2017-11-03 00:00:00

abstract：BACKGROUND:Even in industrialized countries, health care is not as safe as it should be. The term "patient safety" denotes the non-occurrence of adverse events and the presence of measures to prevent them. METHODS:The literature was selectively reviewed to obtain information on the epidemiology and causes of preventab...

journal_title：Deutsches Arzteblatt international

authors： Hoffmann B,Rohe J

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Data on the prevalence and regional distribution of the metabolic syndrome in Germany are lacking, in particular for primary care. METHODS:In October 2005 anthropometric measurements were taken from 35 869 consecutive patients aged 18 to 99 years, in 1511 primary care practices. Waist circumference, blood...

journal_title：Deutsches Arzteblatt international

authors： Moebus S,Hanisch J,Bramlage P,Lösch C,Hauner H,Wasem J,Jöckel KH

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:A number of studies have revealed higher postoperative mortality after operations that were performed toward the end of the week. It is not yet known whether a day-of-the-week effect exists after visceral surgical procedures for cancer in Germany. METHODS:Data on resections of carcinomas of the colon, rectu...

journal_title：Deutsches Arzteblatt international

authors： Anger F,Wellner U,Klinger C,Lichthardt S,Haubitz I,Löb S,Keck T,Germer CT,Buhr HJ,Wiegering A

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:One-third of all patients with epilepsy have persistent seizures despite medical treatment. If the origin of the seizures can be localized to a particular site in the brain, epilepsy surgery is a treatment option that addresses the cause of the problem. METHOD:The presurgical assessment and surgical treatme...

journal_title：Deutsches Arzteblatt international

authors： Schulze-Bonhage A,Zentner J

更新日期：2014-05-02 00:00:00

abstract：BACKGROUND:Cluster-randomized trials (CRT) are needed to compare interventions that are allocated to entire groups of subjects, rather than to individuals. Publications about CRT have become steadily more common over the past decade. Readers of such publications should be able to categorize and interpret the findings o...

journal_title：Deutsches Arzteblatt international

authors： Lorenz E,Köpke S,Pfaff H,Blettner M

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Overweight and obesity are generally thought to elevate morbidity and mortality. New data call this supposed association into question. METHODS:The Cochrane, Pubmed, and other databases were systematically searched for a combination of relevant terms and subject headings. Meta-analyses and cohort studies ba...

journal_title：Deutsches Arzteblatt international

authors： Lenz M,Richter T,Mühlhauser I

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Treatment with checkpoint inhibitors such as anti-programmed death-1 (anti-PD-1), anti-PD-ligand 1 (anti-PD-L1), and anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) antibodies can prolong the survival of cancer patients, but it also induces autoimmune side effects in 86-96% of patients by activating the ...

journal_title：Deutsches Arzteblatt international

authors： Heinzerling L,de Toni EN,Schett G,Hundorfean G,Zimmer L

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:The long-term use of opioid analgesic drugs to treat chronic non-cancer pain (CNCP) is a major component of pain pharmacotherapy. The interpretation of the evidence concerning its efficacy and risks is currently debated. METHODS:An interdisciplinary evidence- and consensus-based S3 guideline was updated on ...

journal_title：Deutsches Arzteblatt international

authors： Häuser W,Bock F,Engeser P,Tölle T,Willweber-Strumpfe A,Petzke F

更新日期：2014-10-24 00:00:00

abstract：BACKGROUND:Otitis externa has a lifetime prevalence of 10% and can arise in acute, chronic, and necrotizing forms. METHODS:This review is based on publications retrieved by a selective search of the pertinent literature. RESULTS:The treatment of acute otitis media consists of anal- gesia, cleansing of the external au...

journal_title：Deutsches Arzteblatt international

authors： Wiegand S,Berner R,Schneider A,Lundershausen E,Dietz A

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:The epidermal growth factor receptor (EGFR) is an important target in the treatment of metastatic colorectal carcinoma (mCRC). The combination of anti-EGFR antibodies with chemotherapy has led to a higher response rate of certain kinds of tumor as well as a significant prolongation of the progression-free in...

journal_title：Deutsches Arzteblatt international

authors： Stintzing S,Heinemann V,Moosmann N,Hiddemann W,Jung A,Kirchner T

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Despite sparse documentation of their long-term therapeutic effects and side effects, antipsychotic drugs have come to be prescribed more frequently for children and adolescents in recent years, both in the USA and in Europe. No current data are available about antipsychotic prescriptions for this age group ...

journal_title：Deutsches Arzteblatt international

authors： Bachmann CJ,Lempp T,Glaeske G,Hoffmann F

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Much new evidence on oral anticoagulation has come to light in recent years. Non-vitamin-K-dependent oral anti- coagulants (NOAC) have been developed and have been introduced into clinical practice. In this review, we present the current state of the evidence on anticoagulation for various indications with v...

journal_title：Deutsches Arzteblatt international

authors： Altiok E,Marx N

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:Recent years have seen a marked increase in laser-pointerrelated injuries, which sometimes involve severe retinal damage and irreversible visual impairment. These injuries are often caused by untested or incorrectly classified devices that are freely available over the Internet. METHODS:We reviewed pertinen...

journal_title：Deutsches Arzteblatt international

authors： Birtel J,Harmening WM,Krohne TU,Holz FG,Charbel Issa P,Herrmann P

更新日期：2017-12-08 00:00:00

abstract：BACKGROUND:The risk of venous thromboembolism (VTE) is 4 to 7 times higher in cancer patients than in the normal population. Moreover, cancer patients who take anticoagulants suffer more frequently from hemorrhagic complications and VTE recurrences. Patients often find low-molecular-weight heparin (LMWH) treatment unpl...

journal_title：Deutsches Arzteblatt international

authors： Beyer-Westendorf J,Klamroth R,Kreher S,Langer F,Matzdorff A,Riess H

更新日期：2019-01-18 00:00:00