The treatment of colorectal carcinoma with monoclonal antibodies: the importance of KRAS mutation analysis and EGFR status.

abstract：BACKGROUND:The risk of venous thromboembolism (VTE) is 4 to 7 times higher in cancer patients than in the normal population. Moreover, cancer patients who take anticoagulants suffer more frequently from hemorrhagic complications and VTE recurrences. Patients often find low-molecular-weight heparin (LMWH) treatment unpl...

journal_title：Deutsches Arzteblatt international

authors： Beyer-Westendorf J,Klamroth R,Kreher S,Langer F,Matzdorff A,Riess H

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:In Germany, public interest in a vegan diet is steadily growing. There are, however, no current data on the macro- and micronutrient status of vegans. METHODS:In a cross-sectional study entitled "The Risks and Benefits of a Vegan Diet" (RBVD), we investigated the dietary intake, basic laboratory parameters,...

journal_title：Deutsches Arzteblatt international

authors： Weikert C,Trefflich I,Menzel J,Obeid R,Longree A,Dierkes J,Meyer K,Herter-Aeberli I,Mai K,Stangl GI,Müller SM,Schwerdtle T,Lampen A,Abraham K

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Early gastro-esophageal cancer is staged as m1 to m3 depending on the infiltration of the anatomical layers of the mucosa or, analogously, as sm1 to sm3 depending on the depth of infiltration into the submucosa. The risk of lymph node metastases is low in mucosal carcinoma but increases with the depth of inf...

journal_title：Deutsches Arzteblatt international

authors： Gockel I,Hoffmeister A

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Avulsed frontal teeth often cannot be saved because of improper or lack of initial treatment. The result is a need for multiple interventions over the patient's lifetime, which also carry a high financial cost. METHODS:We explored the subject of lost anterior teeth in young patients with a PubMed search bas...

journal_title：Deutsches Arzteblatt international

authors： Brüllmann D,Schulze RK,d'Hoedt B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Infections with multidrug-resistant gram-negative bacteria are hard to treat and cause high morbidity and mortality. The direct transmission of such pathogens is well documented, and measures to protect other patients would seem indicated. Nonetheless, evidence-based recommendations are not yet available bec...

journal_title：Deutsches Arzteblatt international

authors： Mattner F,Bange FC,Meyer E,Seifert H,Wichelhaus TA,Chaberny IF

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend psychosocial care as an integral part of medical treatment, but access is often limited. Technology-based approaches provide an attractive opportunity to optimize health outcomes and quality of life in people with chronic somatic diseases e.g. by means of Internet- and mobile-ba...

journal_title：Deutsches Arzteblatt international

authors： Bendig E,Bauereiß N,Ebert DD,Snoek F,Andersson G,Baumeister H

更新日期：2018-11-05 00:00:00

abstract：BACKGROUND:Pre-hospital hypotension in trauma patients is associated with high mortality. Especially for patients with severe traumatic brain injury (TBI), arterial normotension or even hypertension (AHT) is considered an important mechanism for sustaining adequate cerebral perfusion pressure. The effect of pre-hospita...

journal_title：Deutsches Arzteblatt international

authors： Sellmann T,Miersch D,Kienbaum P,Flohé S,Schneppendahl J,Lefering R,DGU Trauma Registry.

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The German Standing Committee on Vaccination Recommendations (Ständige Impfkommission, STIKO) recommends standard vaccination against pneumococcal infections for all persons aged 60 or older, and for all persons of any age with an increased health risk. It is not known how many persons in the target group in...

journal_title：Deutsches Arzteblatt international

authors： Theidel U,Kuhlmann A,Braem A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Surgical site infections (SSI) are among the most common healthcare- associated infections. The aim of our explorative study was to determine how selected climatic factors are associated with SSI rates. METHODS:SSI rates were calculated for operative procedures included in the surgi- cal site infection surv...

journal_title：Deutsches Arzteblatt international

authors： Aghdassi SJS,Schwab F,Hoffmann P,Gastmeier P

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:A number of studies have revealed higher postoperative mortality after operations that were performed toward the end of the week. It is not yet known whether a day-of-the-week effect exists after visceral surgical procedures for cancer in Germany. METHODS:Data on resections of carcinomas of the colon, rectu...

journal_title：Deutsches Arzteblatt international

authors： Anger F,Wellner U,Klinger C,Lichthardt S,Haubitz I,Löb S,Keck T,Germer CT,Buhr HJ,Wiegering A

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:The prevalence of latent/subclinical hypothyroidism is between 3% and 10%, according to epidemiologic studies that have been carried out in the USA, the United Kingdom, and Denmark. As persons with latent hypo - thyroidism are often asymptomatic, the diagnosis is often made incidentally in routine laboratory...

journal_title：Deutsches Arzteblatt international

authors： Schübel J,Feldkamp J,Bergmann A,Drossard W,Voigt K

更新日期：2017-06-23 00:00:00

abstract：INTRODUCTION:Crohn's disease and ulcerative colitis are chronic inflammatory diseases resulting from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This inappropriate response is promoted by certain environmental factors. Both diseases manife...

journal_title：Deutsches Arzteblatt international

authors： Baumgart DC

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The percentage of organ donors among the German population is very low, and the supply of organs does not meet the demand. Relatively few organ explantations are performed in Germany, compared to other countries. The central element leading up to organ explantation is the donor's consent. This can be express...

journal_title：Deutsches Arzteblatt international

authors： Küpers M,Dudda M,Kauther MD,Schwarz B,Hausen SA,Jöckel KH

更新日期：2020-03-13 00:00:00

abstract：BACKGROUND:Delirium is a common complication in elderly hospitalized patients. It prolongs the length of hospital stay, raises costs, increases the workload of the nursing staff, and may necessitate transfer of the patient to a nursing home. The risk of postoperative delirium is particularly high in elderly patients wi...

journal_title：Deutsches Arzteblatt international

authors： Kratz T,Heinrich M,Schlauß E,Diefenbacher A

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:Lung cancer is the leading cause of death from cancer in Germany. 90% of cases are due to the inhalation of tobacco smoke. About 40% of patients with newly diagnosed lung cancer are still smokers. A structured smoking cessation program is medically reasonable in this situation but is only rarely offered. ME...

journal_title：Deutsches Arzteblatt international

authors： Andreas S,Rittmeyer A,Hinterthaner M,Huber RM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Multi-center observational studies in surgery can yield important findings, as long as they are appropriately designed and monitored and employ modern methods of statistical analysis. METHODS:In a multi-center quality assurance study carried out in 346 German hospitals from 2000 to 2004, data were collected...

journal_title：Deutsches Arzteblatt international

authors： Kube R,Gastinger I,Mroczkowski P,Ptok H,Wolff S,Lippert H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend using aspirin, clopidogrel, beta-blockers, statins, and angiotensin converting enzyme (ACE) inhibitors after acute myocardial infarction (AMI). Although there is evidence that patients often stop taking these medications prematurely, long-term data reflecting the actual reality o...

journal_title：Deutsches Arzteblatt international

authors： Mangiapane S,Busse R

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Atraumatic necrosis of the femoral head is a common cause of hip arthrosis in middle age. In Germany, it affects 5000-7000 patients per year, corresponding to an incidence of 0.01%. Though rarer than primary hip arthrosis, it is still of major clinical and socio-economic significance. Patients with this prob...

journal_title：Deutsches Arzteblatt international

authors： Arbab D,König DP

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Recent years have seen a further decline in the nationwide case fatality rate after major trauma in Germany, but it has not been clear until now whether all centers providing trauma care achieve comparable results. We have attempted to answer this question using data from the trauma registry of the German So...

journal_title：Deutsches Arzteblatt international

authors： Hilbert P,Lefering R,Stuttmann R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Even in industrialized countries, health care is not as safe as it should be. The term "patient safety" denotes the non-occurrence of adverse events and the presence of measures to prevent them. METHODS:The literature was selectively reviewed to obtain information on the epidemiology and causes of preventab...

journal_title：Deutsches Arzteblatt international

authors： Hoffmann B,Rohe J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is a common retinal disease in older people. In Europe, about 1.6% of persons over age 65 and more than 13% of persons over age 85 have late-stage AMD, which can severely impair vision. The development of AMD is influenced both by environmental factors and by a strong h...

journal_title：Deutsches Arzteblatt international

authors： Weber BH,Charbel Issa P,Pauly D,Herrmann P,Grassmann F,Holz FG

更新日期：2014-02-21 00:00:00

abstract：BACKGROUND:Despite sparse documentation of their long-term therapeutic effects and side effects, antipsychotic drugs have come to be prescribed more frequently for children and adolescents in recent years, both in the USA and in Europe. No current data are available about antipsychotic prescriptions for this age group ...

journal_title：Deutsches Arzteblatt international

authors： Bachmann CJ,Lempp T,Glaeske G,Hoffmann F

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Proper infant nutrition promotes healthy growth and development and lowers the risk of disease in later life. METHODS:This review is based on pertinent articles retrieved by a selective search, including guidelines, meta-analyses, and systematic reviews. RESULTS:Infants should be exclusively breast-fed unt...

journal_title：Deutsches Arzteblatt international

authors： Prell C,Koletzko B

更新日期：2016-06-24 00:00:00

abstract：BACKGROUND:In peripheral arterial occlusive disease (PAOD), arterial stenosis or occlusion impairs perfusion in the territory of the distal portion of the aorta and the iliac and leg arteries. In Germany, the prevalence of PAOD rises with age, reaching 20% among persons over age 70. METHODS:This guideline was prepared...

journal_title：Deutsches Arzteblatt international

authors： Lawall H,Huppert P,Espinola-Klein C,Rümenapf G

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Basically two types of sweating exist: thermoregulatory and emotional sweating. They are controlled by different centers: thermo regulatory sweating is regulated predominantly by the hypothalamus, emotional sweating predominantly by the limbic system. Enhanced sweating, called hyperhidrosis, can be generaliz...

journal_title：Deutsches Arzteblatt international

authors： Schlereth T,Dieterich M,Birklein F

更新日期：2009-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.3238/arztebl.2017.0661.]. ...

journal_title：Deutsches Arzteblatt international

authors：

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Familial hypercholesterolemia (FH) is a congenital disorder of lipid metabolism characterized by a marked elevation of the plasma concentration of LDL (low-density lipoprotein) cholesterol beginning in childhood and by the early onset of coronary heart disease. It is among the commonest genetic disorders, wi...

journal_title：Deutsches Arzteblatt international

authors： Klose G,Laufs U,März W,Windler E

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:The conservative treatment of traumatic thoracolumbar vertebral fractures is often not clearly defined. METHODS:This review is based on articles retrieved by a systematic search in the PubMed and Web of Science databases for publications up to February 2018 dealing with the conservative treatment of traumat...

journal_title：Deutsches Arzteblatt international

authors： Spiegl UJ,Fischer K,Schmidt J,Schnoor J,Delank S,Josten C,Schulte T,Heyde CE

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Otitis externa has a lifetime prevalence of 10% and can arise in acute, chronic, and necrotizing forms. METHODS:This review is based on publications retrieved by a selective search of the pertinent literature. RESULTS:The treatment of acute otitis media consists of anal- gesia, cleansing of the external au...

journal_title：Deutsches Arzteblatt international

authors： Wiegand S,Berner R,Schneider A,Lundershausen E,Dietz A

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:4-10% of the general population and 20% of primary care patients have what are called "non-specific, functional, and somatoform bodily complaints." These often take a chronic course, markedly impair the sufferers' quality of life, and give rise to high costs. They can be made worse by inappropriate behavior ...

journal_title：Deutsches Arzteblatt international

authors： Schaefert R,Hausteiner-Wiehle C,Häuser W,Ronel J,Herrmann M,Henningsen P

更新日期：2012-11-01 00:00:00