Abstract:
BACKGROUND:When reading reports of medical research findings, one is usually confronted with p-values. Publications typically contain not just one p-value, but an abundance of them, mostly accompanied by the word "significant." This article is intended to help readers understand the problem of multiple p-values and how to deal with it. METHODS:When multiple p-values appear in a single study, this is usually a problem of multiple testing. A number of valid approaches are presented for dealing with the problem. This article is based on classical statistical methods as presented in many textbooks and on selected specialized literature. RESULTS:Conclusions from publications with many "significant" results should be judged with caution if the authors have not taken adequate steps to correct for multiple testing. Researchers should define the goal of their study clearly at the outset and, if possible, define a single primary endpoint a priori. If the study is of an exploratory or hypothesis-generating nature, it should be clearly stated that any positive results might be due to chance and will need to be confirmed in further targeted studies. CONCLUSIONS:It is recommended that the word "significant" be used and interpreted with care. Readers should assess articles critically with regard to the problem of multiple testing. Authors should state the number of tests that were performed. Scientific articles should be judged on their scientific merit rather than by the number of times they contain the word "significant."
journal_name
Dtsch Arztebl Intjournal_title
Deutsches Arzteblatt internationalauthors
Victor A,Elsässer A,Hommel G,Blettner Mdoi
10.3238/arztebl.2010.0050subject
Has Abstractpub_date
2010-01-01 00:00:00pages
50-6issue
4issn
1866-0452journal_volume
107pub_type
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