Fluid Shear Stress Increases Osteocyte and Inhibits Osteoclasts via Downregulating Receptor-Activator of Nuclear Factor κB (RANK)/Osteoprotegerin Expression in Myeloma Microenvironment.

abstract：BACKGROUND:An emerging body of literature has recently defined a reduced risk of cancer following the use of nonsteroidal anti-inflammatory drugs (NSAIDs), which are generally able to exert an apoptotic property and inhibitory effects on the activity and/or expression of matrix metalloproteinases (MMPs). This study was...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Mirshafiey A,Khorramizadeh MR,Saadat F,Rehm BH

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Although many epidemiology studies have investigated the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and their associations with lung cancer (LC), definite conclusions cannot be drawn. To clarify the effects of MTHFR polymorphisms on the risk of LC, we performed a meta-analysis in Chinese ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu NB,Li J,Qi JF,Zhang ZZ,Wu X,Zhang JH

更新日期：2014-12-29 00:00:00

abstract：BACKGROUND:There is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma perox...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Maes M,Kubera M,Uytterhoeven M,Vrydags N,Bosmans E

更新日期：2011-04-01 00:00:00

abstract：:BACKGROUND Sesquiterpene lactones have gained tremendous attention owing to their potent anticancer properties. The main focus of this study was to evaluate the anticancer effects of a naturally occurring sesquiterpene lactone, santonin, against human breast cancer SK-BR-3 cells. MATERIAL AND METHODS Cell counting kit...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wu Z,Wang C,Huang M,Tao Z,Yan W,Du Y

更新日期：2019-05-18 00:00:00

abstract：BACKGROUND:Bifenthrin is a synthetic pyrethroid insecticide derivative of naturally occurring pyrethrins from chrysanthemum flowers. Bifenthrin is considered relatively safe and therefore incorporated as the active ingredient in preparations sold over the counter for household use. Recent studies have raised concern th...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Nandi A,Chandil D,Lechesal R,Pryor SC,McLaughlin A,Bonventre JA,Flynnx K,Weeks BS

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The purpose of our research was to determine diagnosis and outcomes for non-contact lens related Acanthamoeba keratitis in south India. MATERIAL/METHODS:A retrospective review of the medical and microbiology records of culture-positive Acanthamoeba cases presenting between 1987 and 2001 to a tertiary eye ca...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Srinivasan M,Burman S,George C,Nirmalan PK

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Several studies have reported the association of PTPN2 gene with type 1 diabetes mellitus (T1DM) in many populations but not in the Chinese Han population. Therefore, the goal of our study was to replicate the reported association between 2 single-nucleotide polymorphisms (SNPs; rs478582 and rs2542151) in th...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Peng H,Li J,Chen X,Zhou X,Zhu W,Li F

更新日期：2015-09-07 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the effects of different tidal volume (VT) ventilation on paraquat-induced acute lung injury or acute respiratory distress syndrome (ALI/ARDS) in piglets. MATERIAL AND METHODS:We developed ALI/ARDS models in piglets by intraperitoneal injection of paraquat (PQ). The pigl...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lan C,Wang J,Li L,Li H,Li L,Su Q,Che L,Liu L,Di M

更新日期：2015-02-11 00:00:00

abstract：BACKGROUND:Lansoprazole (LAN) is a proton pump inhibitor drug (PPI) metabolized by the P-450 liver cytochrome (CYP-450) system. LAN is used in association with antimicrobial agents in Helicobacter pylori (HP) eradication therapy. The 13C-Aminopyrine breath test (ABT) is a non-invasive tool exploring liver CYP-450 metab...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Malfatti F,Giannini E,Emanuela T,Polegato S,Podestà E,Fumagalli A,Cotelessa T,Chiarbonello B,Bellotti M,Botta F,Milazzo S,Testa R

更新日期：2005-02-01 00:00:00

abstract：:BACKGROUND The aim of this study was to determine the relationship between the expression of CD35 and CD64 from white blood cells (neutrophil, monocytes, and lymphocytes) and acute infectious diseases in children. MATERIAL AND METHODS The blood samples were collected from 104 children with infections (42 viral infecti...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lu L,Jin X,Zhang Q

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease and is usually associated with a poor prognosis. IPF patients have a significant impairment in health-related quality of life (HRQL), both in terms of physical and psychological functioning. A substantial number of dyspnea scale...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Baddini Martinez JA,Martinez TY,Lovetro Galhardo FP,de Castro Pereira CA

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:This article discusses the value of high-resolution computed tomography (HRCT) in the diagnosis and treatment of pulmonary infections. Lung infection caused by pathogens is an important cause of death. Traditional methods to treat lung infection involved empirical antibiotic therapy. Thin-slice CT scanning i...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Nie Y,Li C,Zhang J,Wang H,Han P,Lv X,Xu X,Guo M

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Previous studies have shown that administration of ghrelin exhibits protective and therapeutic effects in the gut. The aim of the present investigation was to examine the influence of ghrelin administration on the course of cysteamine-induced duodenal ulcers, as well as effects on mucosal production of oxyge...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Warzecha Z,Ceranowicz D,Dembiński A,Ceranowicz P,Cieszkowski J,Kuwahara A,Kato I,Dembiński M,Konturek PC

更新日期：2012-05-01 00:00:00

abstract：:BACKGROUND Long non-coding RNAs (LncRNAs) could potentially function as diagnostic markers for gastric carcinoma. Nevertheless, the expression profile and biological feature of LncRNAs in early gastric cancer (EGC) remains to be explored. MATERIAL AND METHODS LncRNA expression microarray analysis was performed on 6 pa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu H,Yang AM,Lu XH,Feng L,Wu X,Cui JF,Cheng JY

更新日期：2019-12-29 00:00:00

abstract：BACKGROUND:Cyclic vomiting syndrome (CVS) in adults is a disorder characterized by recurrent and stereotypic episodes of severe nausea, vomiting and abdominal pain separated by symptom-free intervals. Our goal was to investigate gastric emptying (GE) in CVS patients. MATERIAL AND METHODS:This was a retrospective study...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Cooper CJ,Said S,Bizet J,Alkahateeb H,Sarosiek I,McCallum RW

更新日期：2014-08-22 00:00:00

abstract：:BACKGROUND Splenic injury is the leading cause of major bleeding after blunt abdominal trauma. We examined the clinical and radiological presentations, management, and outcome of blunt splenic injuries (BSI) in our institution. MATERIAL AND METHODS A retrospective study of BSI patients between 2011 and 2014 was conduc...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jabbour G,Al-Hassani A,El-Menyar A,Abdelrahman H,Peralta R,Ellabib M,Al-Jogol H,Asim M,Al-Thani H

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:Gadolinium chelates (GCs) have been traditionally considered as non-nephrotoxic magnetic resonance imaging (MRI) contrast materials. However, it has been suggested in some recent articles that GCs may have a nephrotoxic potential, but most of these reports are retrospective. However, the evaluated contrast a...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gok Oguz E,Kiykim A,Turgutalp K,Olmaz R,Ozhan O,Muslu N,Horoz M,Bardak S,Sungur MA

更新日期：2013-11-06 00:00:00

abstract：:The aim of our study was to assess the antitumor effect of electrochemical therapy (ECT) in the mice bearing advanced transplantable tumours. Mouse mammary cancer 16/C (group 1) and fibrosarcoma F69-3 (group 2) were transplanted subcutaneously (s.c.) into the C3H or BALB/c mice, respectively. Twenty animals in each gr...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wójcicki M,Droździk M,Olewniczak S,Opolski A,Wietrzyk J,Radzikowski C,Kaczmarek B,Wrzesiński M,Romanowski M,Kamiński M,Zieliński S

更新日期：2000-05-01 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate the ability of coronary computed tomographic angiography (CCTA) characteristics of high-risk plaque (HRP) in moderate stenosis to improve differentiation of myocardial ischemia detected by stress CT perfusion (CTP) imaging. MATERIAL AND METHODS Sixty-two patients wit...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qi L,Shi K,Li C,Ju Z,Mao D,Zhang L,Qu X,Hua Y,Li M

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:In recent years, extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have emerged in many hospitals worldwide. The increasing dissemination and long-term carriage of these organisms within the community carry tremendous implications on the empirical therapy of community-acquired infection. ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Borer A,Gilad J,Menashe G,Peled N,Riesenberg K,Schlaeffer F

更新日期：2002-01-01 00:00:00

abstract：:BACKGROUND Obestatin, primarily recognized as a peptide within the gastrointestinal system, has been shown to benefit the cardiovascular system. We designed this experiment to study the protective role and underlying mechanism of obestatin against ischemia-reperfusion(I/R) injury in myocardial cells. MATERIAL AND METH...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang Q,Dong XW,Xia JY,Xu KY,Xu ZR

更新日期：2017-05-04 00:00:00

abstract：:Gonadal steroids are known to be of prime importance in the normal maintenance of brain function. Data from epidemiological studies suggest that the decline in estrogen following menopause may increase the risk of neurodegenerative diseases. There is accumulating epidemiological evidence for neuroprotection by estroge...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Członkowska A,Ciesielska A,Joniec I

更新日期：2003-10-01 00:00:00

abstract：:BACKGROUND Nimotuzumab is an anti-EGFR monoclonal antibody which has been widely used in cancer treatment. However, the safety and efficacy of nimotuzumab combined with chemotherapy in locally advanced or metastatic esophageal cancer patients remain unclear. MATERIAL AND METHODS To address this open question, we colle...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Han X,Lu N,Pan Y,Xu J

更新日期：2017-01-24 00:00:00

abstract：:BACKGROUND Epithelial ovarian cancer (EOC) has a high mortality rate and is a common malignant tumor of women, seriously impairing health. Chemoresistance is one of the major causes of poor prognosis. Therefore, analyzing the molecular mechanism of paclitaxel resistance has great significance. MATERIAL AND METHODS We ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Shi C,Wang M

更新日期：2018-12-06 00:00:00

abstract：:BACKGROUND The current research work aimed to explore the protective role of myricetin against cataractogenesis in humans, in terms of its anti-apoptotic potential. MATERIAL AND METHODS Human eye lens epithelial cells were exposed to oxidative stress by treating with hydrogen peroxide (H₂O₂). The levels of superoxide ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yang Y,Xu X,Liu Q,Huang H,Huang X,Lv H

更新日期：2020-04-26 00:00:00

abstract：BACKGROUND:Although reactive lymphoid hyperplasia (RLH) can be found in various organs, including the gastrointestinal tract, orbit, lung, and skin, its occurrence in the liver is rare. CASE REPORT:We report the case of a 47-year-old RLH woman who was identified with RLH of the liver during clinical follow- up of prim...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Fukuo Y,Shibuya T,Fukumura Y,Mizui T,Sai JK,Nagahara A,Tsukada A,Matsumoto T,Suyama M,Watanabe S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:NFKBIA encodes the inhibitors of nuclear factor-κB (NF-κB), which regulate the translation of the genes involved in the inflammatory and immune reactions. Polymorphisms (rs2233406, rs3138053, and rs696) of NFKBIA have been implicated in susceptibility to many cancer types. MATERIAL AND METHODS:To evaluate t...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang M,Huang J,Tan X,Bai J,Wang H,Ge Y,Xiong H,Shi J,Lu W,Lv Z,Liang C

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:The common and effective treatment for degenerative lumbar diseases is lumbar spinal fusion. Controversy still exists on the choice for instrumentation with spinal fusion procedures. Therefore, we conducted this meta-analysis exclusively of RCTs to compare the clinical outcomes of patients receiving bilatera...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li X,Lv C,Yan T

更新日期：2015-03-16 00:00:00

abstract：BACKGROUND:Children with Down syndrome (DS) present with delays in motor development. The reduced size of the cerebrum, brain maturation disorders, and pathophysiological processes lead to motor development delay. The aim of this study was to examine the gross motor function and estimate what motor abilities are signif...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Malak R,Kostiukow A,Krawczyk-Wasielewska A,Mojs E,Samborski W

更新日期：2015-07-01 00:00:00

abstract：:Cataract is the leading cause of irreversible blindness worldwide. Increasing evidence indicates that oxidative stress is an important risk factor contributing to the development of cataract. Moreover, the enhancement of the antioxidant defense system may be beneficial to prevent or delay the cataractogenesis. The ter...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qin L,Tao Y,Wang L,Chen H,Liu Y,Huang YF

更新日期：2016-09-08 00:00:00