Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats.

Abstract:

BACKGROUND:Previous studies have shown that administration of ghrelin exhibits protective and therapeutic effects in the gut. The aim of the present investigation was to examine the influence of ghrelin administration on the course of cysteamine-induced duodenal ulcers, as well as effects on mucosal production of oxygen free radicals and duodenal antioxidant defense. MATERIAL/METHODS:Duodenal ulcers were induced in male Wistar rats by cysteamine administered intragastrically at the dose of 200 mg/kg in 1 ml of saline, 3 times at 4-h intervals. Starting 24 h after the first dose of cysteamine, rats were treated intraperitoneally twice a day with saline or ghrelin given at the dose of 4, 8 or 16 nmol/kg/dose. Seven days after administration of the first dose of cysteamine, the study was terminated. RESULTS:Induction of ulcers by cysteamine was accompanied by a reduction in duodenal blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD); whereas mucosal concentration of interleukin-1β and malonyldialdehyde (MDA - an index of lipid peroxidation) were increased. Treatment with ghrelin increased healing rate of duodenal ulcers and enhanced duodenal blood flow, mucosal DNA synthesis and mucosal activity of SOD, and reduced mucosal concentration of interleukin-1β and MDA. CONCLUSIONS:Treatment with ghrelin increases the healing rate of duodenal ulcers and this effect is related, at least in part, to improvement of duodenal mucosal blood flow, mucosal cell proliferation and antioxidant defense, as well as being related to reduction in mucosal oxidative stress and inflammatory response.

journal_name

Med Sci Monit

authors

Warzecha Z,Ceranowicz D,Dembiński A,Ceranowicz P,Cieszkowski J,Kuwahara A,Kato I,Dembiński M,Konturek PC

doi

10.12659/msm.882727

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

BR181-7

issue

5

eissn

1234-1010

issn

1643-3750

pii

882727

journal_volume

18

pub_type

杂志文章
  • Role of Circulating Tumor Cell (CTC) Monitoring in Evaluating Prognosis of Triple-Negative Breast Cancer Patients in China.

    abstract::BACKGROUND Breast cancer (BC) is the most common malignant tumor in females. This study investigated the role and utility of CTC monitoring in evaluating the prognosis of triple-negative breast cancer patients. MATERIAL AND METHODS We enrolled 286 female triple-negative breast cancer patients who were diagnosed at and...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.902637

    authors: Zhang Y,Lv Y,Niu Y,Su H,Feng A

    更新日期:2017-06-23 00:00:00

  • Detection of Atherosclerotic Plaques in the Rabbit Aorta Using Ultrasound Microbubbles Conjugated to Interleukin-18 Antibodies.

    abstract::BACKGROUND The purpose of the study was to investigate the ability of microbubbles (MBs) targeting interleukin-18 (IL-18) to detect plaques in a rabbit atherosclerotic plaque model. MATERIAL AND METHODS A rabbit atherosclerotic plaque model was established. The locations of the atherosclerotic plaques were verified by...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.907572

    authors: Jiang ZZ,Liu XT,Ma CY,He C,Li XY,Hou CL,Cheng ZS,Xia GY

    更新日期:2017-11-16 00:00:00

  • Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.

    abstract:BACKGROUND:Benzodiazepine binding sites distinct from the GABA-receptor-chloride-complex in the central nervous system have been recognized in many peripheral tissues, but their physiological role remains unexplained. Our study was undertaken to examine the effects of diazepam, clonazepam, and PK 11195, a peripheral be...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Rajtar G,Zółkowska D,Kleinrok Z

    更新日期:2002-04-01 00:00:00

  • Neurotransmitter role of endogenous morphine in CNS.

    abstract::Endogenous morphine is present in the mammalian brain as determined by gas chromatography/mass spectrometry. The criteria essential for satisfying the definition of morphine as a neurotransmitter are examined. The detection of endogenous morphine-like compounds inside brain neurons by immunocytochemistry and the Ca(+)...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,评审

    doi:

    authors: Guarna M,Ghelardini C,Galeotti N,Stefano GB,Bianchi E

    更新日期:2005-06-01 00:00:00

  • Comparative analysis of diagnostic probability estimates of some common diagnoses among family doctors, medical residents, and medical students reveals negative correlation between age and estimate of chronic obstructive pulmonary disease (COPD).

    abstract:BACKGROUND:Patients with their given complaints and symptoms expect certain diagnoses to be estimated with the same probability when seen by different family doctors. These estimations showed extreme variation among family doctors in Switzerland. The present study investigated whether there is any difference in the pro...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Vajer P,Szélvári A,Vörös K,Torzsa P,Eory A,Dunai K,Tamás F,Kalabay L

    更新日期:2010-03-01 00:00:00

  • Proteobacteria Acts as a Pathogenic Risk-Factor for Chronic Abdominal Pain and Diarrhea in Post-Cholecystectomy Syndrome Patients: A Gut Microbiome Metabolomics Study.

    abstract::BACKGROUND Laparoscopic cholecystectomy (LC) is regarded as the criterion standard for gallstone therapy, but post-cholecystectomy syndrome (PCS) is a common complication. This study aimed to analyze and identify differences in gut microbiome in PCS patients. MATERIAL AND METHODS This study involved 8 PCS patients (RS...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.915984

    authors: Kang Z,Lu M,Jiang M,Zhou D,Huang H

    更新日期:2019-09-29 00:00:00

  • Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study.

    abstract:BACKGROUND:Risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), may be increased in liver cirrhosis. We conducted a single-center study to explore the epidemiology, risk factors, and in-hospital mortality of VTE in Chinese patients with liver cirrhosis. MATERIAL/METHO...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896153

    authors: Zhang X,Qi X,De Stefano V,Hou F,Ning Z,Zhao J,Peng Y,Li J,Deng H,Li H,Guo X

    更新日期:2016-03-24 00:00:00

  • Correlation of T Cell Immunoglobulin and ITIM Domain (TIGIT) and Programmed Death 1 (PD-1) with Clinicopathological Characteristics of Renal Cell Carcinoma May Indicate Potential Targets for Treatment.

    abstract::BACKGROUND This study investigated the correlation of programmed death 1 (PD-1) and T cell immunoglobulin and ITIM domain (TIGIT) with clinicopathological characteristics of renal cell carcinoma (RCC) and explored the biological roles of both proteins in the development, metastasis, and invasion of RCC. MATERIAL AND M...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910388

    authors: Hong X,Wang X,Wang T,Zhang X

    更新日期:2018-09-28 00:00:00

  • Analysis of Risk Factors for Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction and Non-Alcoholic Fatty Liver Disease (NAFLD).

    abstract::BACKGROUND The present research aimed to explore the risk factors for adverse cardiovascular events in elderly patients with acute myocardial infarction (AMI) combined with NAFLD. MATERIAL AND METHODS We included 325 AMI patients hospitalized in the Department of Cardiology. AMI patients underwent emergency thrombolys...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.922913

    authors: Xia W,Yang N,Li Y

    更新日期:2020-06-01 00:00:00

  • Combination lamivudine and adefovir versus entecavir for the treatment of naïve chronic hepatitis B patients: a pilot study.

    abstract:BACKGROUND:The aim of this study was to compare the effect of combination lamivudine (LAM) and adefovir dipivoxil (ADV) versus entecavir (ETV) monotherapy for naïve HBeAg-positive chronic hepatitis B (CHB) patients. MATERIAL/METHODS:Fifty enrolled patients with CHB were evenly divided into 2 groups: a group treated wi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.889443

    authors: Du QW,Ding JG,Sun QF,Hong L,Cai FJ,Zhou QQ,Wu YH,Fu RQ

    更新日期:2013-09-09 00:00:00

  • Peroxisome Proliferator Activated Receptor gamma (PPARγ) Agonist Rosiglitazone Ameliorate Airway Inflammation by Inhibiting Toll-Like Receptor 2 (TLR2)/Nod-Like Receptor with Pyrin Domain Containing 3 (NLRP3) Inflammatory Corpuscle Activation in Asthmatic

    abstract::BACKGROUND The purpose of this study was to explore the function and mechanism of peroxisome proliferator activated receptor agonist (PPARγ) in the toll-like receptor 2 (TLR2)/nod-like receptor with pyrin domain containing 3 (NLRP3) inflammatory corpuscle pathway of asthmatic mice. MATERIAL AND METHODS Eighteen female...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910766

    authors: Cheng Y,Li S,Wang M,Cheng C,Liu R

    更新日期:2018-12-13 00:00:00

  • Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.

    abstract:BACKGROUND:Hepatorenal syndrome (HRS) is a serious complication of advanced chronic liver disease. Abdominal compartment syndrome (ACS) occurs with dysfunction of multiple organs when abdominal pressure increases. Here, we report on a novel model of ACS with ascites and a model of HRS in rats to observe the urea transp...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.894232

    authors: Song W,Qi X,Zhang W,Zhao Y,Cao Y,Wang F,Yang C

    更新日期:2015-09-28 00:00:00

  • Klatskin Tumor: A Population-Based Study of Incidence and Survival.

    abstract::BACKGROUND Klatskin tumor (KCC) is a rare type of tumor, with an annual incidence rate of no more than 1: 100 000. Because of its rarity, KCC is difficult to investigate. The present study provides new insights into KCC by a using public database. MATERIAL AND METHODS We used the Surveillance, Epidemiology, and End Re...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.914987

    authors: Zhang X,Liu H

    更新日期:2019-06-17 00:00:00

  • Echocardiographic Changes in Newly Diagnosed Type 2 Diabetes Mellitus Patients with and without Hypertension.

    abstract::BACKGROUND Whether type 2 diabetes mellitus (T2DM) is independently associated with structural heart abnormalities is controversial because of confounders associated with T2DM. This study aimed to investigate echocardiographic features in patients with newly diagnosed T2DM, exploring changes in cardiac structure and f...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.918972

    authors: Zhao Z,Hou C,Ye X,Cheng J

    更新日期:2020-01-26 00:00:00

  • Effect of hydroxyethyl starch (HAES) on degree and kinetics of erythrocyte aggregation studied with dielectric spectroscopy method.

    abstract:BACKGROUND:Colloidal fluids, e.g. hydroxyethyl starch (HAES), used as blood plasma substitutes during acute controlled normovolemic hemodilution may cause erythrocyte aggregation. The aim of the presented study was to assess the degree and rate of erythrocyte aggregation in the media containing different concentrations...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Jaroszyński W,Keslinka E,Wujtewicz M,Suchorzewska J,Kwiatkowski B

    更新日期:2002-07-01 00:00:00

  • Autoantibodies against Cajal bodies in systemic lupus erythematosus.

    abstract:BACKGROUND:Cajal bodies (CB) are distinct sub-nuclear domains rich in small nuclear ribonucleoprotein particles (snRNPs); they are involved in pre-mRNA processing. Lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production against different nuclear molecules, including those involved in...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Vázquez-Talavera J,Ramírez-Sandoval R,Esparza Ibarra E,Avalos-Díaz E,Herrera-Esparza R

    更新日期:2004-05-01 00:00:00

  • Anterograde Fixation Module for Posterior Acetabular Column Fracture: Computer-Assisted Determination of Optimal Entry Point, Angle, and Length for Screw Insertion.

    abstract::BACKGROUND The aim of this study was to provide valid data for a plate-screw fixation model for fractured posterior-anterior columns of the acetabulum. MATERIAL AND METHODS Nineteen cadaveric bony hemi-pelvis specimens were obtained and 50 healthy adults were enrolled. The modified Stoppa approach and computed tomogra...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896313

    authors: Xu Y,Lin C,Zhang L,Lin M,Lai J,Cao S,Peng G,Feng K,Yan G,Cai D,Wang G

    更新日期:2016-09-01 00:00:00

  • Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer.

    abstract::BACKGROUND Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expression level is negatively associated with the prognosis of glioma patients. However, the...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.923531

    authors: Feng Y,Guo C,Wang H,Zhao L,Wang W,Wang T,Feng Y,Yuan K,Huang G

    更新日期:2020-07-27 00:00:00

  • Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure.

    abstract:BACKGROUND:L-arginine, the precursor of nitric oxide, may restore nitric oxide levels and bioavailability and influence symptom severity, quality of life (QoL), physical performance, and left ventricular (LV) diastolic abnormalities in patients with chronic systolic heart failure (HF). The aim was to evaluate the effec...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Fontanive P,Saponati G,Iurato A,Volterrani C,Boni A,Piccioni L,Dini FL,L-Arginine in Heart Failure Study Group.

    更新日期:2009-12-01 00:00:00

  • Use of Volar Locking Plate Versus Intramedullary Nailing for Fixation of Distal Radius Fractures: A Retrospective Analysis of Clinical and Radiographic Outcomes.

    abstract::BACKGROUND The objective of this study was to evaluate clinical and radiographic outcomes of volar plate versus intramedullary nailing for fixation of distal radius fractures. MATERIAL AND METHODS This retrospective study included 64 patients with extra-articular and simple intra-articular fractures of the distal radi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.908762

    authors: Çalbıyık M,Ipek D

    更新日期:2018-01-30 00:00:00

  • A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders.

    abstract:BACKGROUND:L-carnitine was proposed as a potential treatment for patients diagnosed with an autism spectrum disorder to improve mitochondrial dysfunction, but no prior randomized controlled trials have been conducted. MATERIAL/METHODS:Thirty subjects diagnosed with an ASD were randomly assigned to receive a standardiz...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/msm.881792

    authors: Geier DA,Kern JK,Davis G,King PG,Adams JB,Young JL,Geier MR

    更新日期:2011-06-01 00:00:00

  • Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer's disease risk.

    abstract:BACKGROUND:Some studies have evaluated the association between the Ubiquilin 1 (UBQLN1) gene UBQ-8i polymorphism and Alzheimer's disease (AD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of this association. MATERIAL/METHODS:Case-control studies were ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,meta分析

    doi:10.12659/MSM.891030

    authors: Zhang T,Jia Y

    更新日期:2014-11-12 00:00:00

  • Direct Anterior Approach Versus Posterolateral Approach for Hemiarthroplasty in the Treatment of Displaced Femoral Neck Fractures in Geriatric Patients.

    abstract::BACKGROUND In the present study, we aimed to evaluate early clinical and biochemical outcomes of direct anterior approach (DAA) versus posterolateral approach (PLA) for hemiarthroplasty in the treatment of displaced femoral neck fractures in geriatric patients. MATERIAL AND METHODS Between September 2012 and September...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.919993

    authors: Neyisci C,Erdem Y,Bilekli AB,Bek D

    更新日期:2020-01-21 00:00:00

  • PPARγ upregulation induced by vagus nerve stimulation exerts anti-inflammatory effect in cerebral ischemia/reperfusion rats.

    abstract:BACKGROUND:It is well known that peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activated transcription factor, plays a protective role in anti-inflammatory responses in both acute and chronic central nerve system (CNS) insults. Emerging evidence in rats suggests that vagus nerve stimulation (VNS), ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.891407

    authors: Jiang Y,Li L,Liu B,Zhang Y,Chen Q,Li C

    更新日期:2015-01-21 00:00:00

  • Applicability of standard parameters in diagnostics of primary open-angle glaucoma.

    abstract:BACKGROUND:The aim of this study was to evaluate the sensitivity, specificity, and likelihood ratio of standard diagnostic parameters C/D, NFI, and MD and their applicability in diagnostics of primary open-angle glaucoma. MATERIAL AND METHODS:This study included 194 subjects (371 eyes), ages 30 to 65 years old, who un...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.883994

    authors: Polaczek-Krupa B,Grabska-Liberek I

    更新日期:2013-08-09 00:00:00

  • Analysis of Mucosa-Associated Microbiota in Colorectal Cancer.

    abstract::BACKGROUND The aim of this study was to compare the microbiota community structure, assess differences in intestinal bacterial types, and identify metagenomic biomarkers for disparate stages of colorectal cancer formation. MATERIAL AND METHODS A total of 160 individuals were recruited: 61 cases with non-tumor colon we...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.904220

    authors: Xu K,Jiang B

    更新日期:2017-09-14 00:00:00

  • Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy.

    abstract::BACKGROUND Few studies have examined functional brain changes specifically associated with chemotherapy (CTx) in patients with lung cancer. This prospective longitudinal research aimed to explore the change in intrinsic brain activity by investigating patients with lung cancer after CTx. MATERIAL AND METHODS Sixteen p...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.921700

    authors: You J,Hu L,Zhang Y,Chen F,Yin X,Jin M,Chen YC

    更新日期:2020-02-18 00:00:00

  • General anaesthesia for laparascopic adrenalectomy.

    abstract::Surgical treatment of adrenal disorders is increasingly performed under laparascopic approach. Both pneumoperitoneum and adrenal tumour manipulation may induce haemodynamic variations. The aim of this study was to compare the inhalational and intravenous anaesthetic management for laparascopic adrenalectomy. Between 1...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Darvas K,Pinkola K,Borsodi M,Tarjányi M,Winternitz T,Horányi J

    更新日期:2000-05-01 00:00:00

  • The acquisition of reading fluency in an orthographically transparent language (Italian): an eye movement longitudinal study.

    abstract:BACKGROUND:The aim of this study was to examine longitudinally the acquisition of reading fluency in a shallow orthography from the very beginning using eye movement recordings. The development of reading fluency is easier to examine in shallow (such as German, Finnish, or Italian) rather than in opaque (such as Englis...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: De Luca M,Zeri F,Spinelli D,Zoccolotti P

    更新日期:2010-03-01 00:00:00

  • Prevalence of and Risk Factors for Abdominal Bleeding in Patients with External Duodenal Fistula.

    abstract::BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula, but few studies have focused on this problem. The purpose of the present study was to investigate the prevalence of and risk factors for intra-abdominal bleeding in patients with external duodenal fistula. MATERIAL AND METHODS From January 201...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.912651

    authors: Yao Z,Ge Z,Xu X,Pu P,Ren X,Zhao Y,Qin C

    更新日期:2018-12-21 00:00:00