Reactive lymphoid hyperplasia of the liver associated with primary biliary cirrhosis.

Abstract:

BACKGROUND:Although reactive lymphoid hyperplasia (RLH) can be found in various organs, including the gastrointestinal tract, orbit, lung, and skin, its occurrence in the liver is rare. CASE REPORT:We report the case of a 47-year-old RLH woman who was identified with RLH of the liver during clinical follow- up of primary biliary cirrhosis. The mass, found incidentally during a medical examination, appeared on ultrasonogram as a hypoechoic mass in the 7th segment of the liver. Further analyses using composed tomography, magnetic resonance imaging, and angiography suggested malignancy, and we performed lateral segmentectomy of the liver. Histologically, the tumor was composed of lymphoid follicles with germinal centers that expressed kappa and lambda light-chain B-cell markers at equal frequency, and no IgH gene rearrangements were detected in Southern blots. Based on these results, we identified the lesion as RLH. CONCLUSIONS:We suggest that this diagnosis be taken into consideration in other cases involving a space-occupying liver mass associated with autoimmune disease.

journal_name

Med Sci Monit

authors

Fukuo Y,Shibuya T,Fukumura Y,Mizui T,Sai JK,Nagahara A,Tsukada A,Matsumoto T,Suyama M,Watanabe S

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

CS81-6

issue

7

eissn

1234-1010

issn

1643-3750

pii

880915

journal_volume

16

pub_type

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