Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review.

abstract：:The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demons...

journal_title：Frontiers in immunology

authors： Rudolph J,Meinke C,Voss M,Guttek K,Kliche S,Reinhold D,Schraven B,Reinhold A

更新日期：2019-10-01 00:00:00

abstract：:Mycobacterium tuberculosis continues to be one of the most successful pathogens on earth. Upon inhalation of M. tuberculosis by a healthy individual, the host immune system will attempt to eliminate these pathogens using a combination of immune defense strategies. These include the recruitment of macrophages and other...

journal_title：Frontiers in immunology

authors： BoseDasgupta S,Pieters J

更新日期：2014-10-08 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which ser...

journal_title：Frontiers in immunology

authors： Tea F,Pilli D,Ramanathan S,Lopez JA,Merheb V,Lee FXZ,Zou A,Liyanage G,Bassett CB,Thomsen S,Reddel SW,Barnett MH,Brown DA,Dale RC,Brilot F,Australasian New Zealand MOG Study Group.

更新日期：2020-02-06 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. Interferon γ (IFNγ)-primed macrophages stimulated with lipopolysaccharide (LPS) [M(IFNγ+LPS)] produce high levels of pro-inflammatory cytokines such as IL-12, TNFα, and IL-6 and low level...

journal_title：Frontiers in immunology

authors： Ruenjaiman V,Butta P,Leu YW,Pongpanich M,Leelahavanichkul A,Kueanjinda P,Palaga T

更新日期：2020-01-10 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strateg...

journal_title：Frontiers in immunology

authors： Ochando J,Conde P,Utrero-Rico A,Paz-Artal E

更新日期：2019-03-06 00:00:00

abstract：:The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel, previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine development is too slow for vaccines to be used in the control of emerging pandemics. RNA-based vaccines might be suitable to meet this challe...

journal_title：Frontiers in immunology

authors： Sandbrink JB,Shattock RJ

更新日期：2020-12-22 00:00:00

abstract：:The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that transplantation of livers from the same donor was capable of inducing t...

journal_title：Frontiers in immunology

authors： McCaughan GW,Bowen DG,Bertolino PJ

更新日期：2020-09-11 00:00:00

abstract：:The intestinal mucosa is constantly facing a high load of antigens including bacterial antigens derived from the microbiota and food. Despite this, the immune cells present in the gastrointestinal tract do not initiate a pro-inflammatory immune response. Toll-like receptors (TLRs) are pattern recognition receptors exp...

journal_title：Frontiers in immunology

authors： de Kivit S,Tobin MC,Forsyth CB,Keshavarzian A,Landay AL

更新日期：2014-02-18 00:00:00

abstract：:Human Campylobacter infections are progressively rising and of high socioeconomic impact. In the present preclinical intervention study we investigated anti-pathogenic, immuno-modulatory, and intestinal epithelial barrier preserving properties of vitamin D applying an acute campylobacteriosis model. Therefore, seconda...

journal_title：Frontiers in immunology

authors： Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM

更新日期：2019-09-03 00:00:00

abstract：:Attenuated vaccinia virus (VACV) vectors are considered prime vaccine candidates for use in immunotherapy of infectious disease. In spite of this, recent data show that the level of attenuation may hamper the efficient generation of protective CD8 T cells. This suggests that additional adjuvant-like activities may nee...

journal_title：Frontiers in immunology

authors： Zhao Y,Tahiliani V,Salek-Ardakani S,Croft M

更新日期：2012-11-08 00:00:00

abstract：:Endothelial cells are thought to play a central role in the pathogenesis of antiphospholipid syndrome (APS). Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation has been shown to improve endothelial function in a number of diseases; thus, it could be of high clinical relevance in APS. The aim of this study w...

journal_title：Frontiers in immunology

authors： Felau SM,Sales LP,Solis MY,Hayashi AP,Roschel H,Sá-Pinto AL,Andrade DCO,Katayama KY,Irigoyen MC,Consolim-Colombo F,Bonfa E,Gualano B,Benatti FB

更新日期：2018-03-02 00:00:00

abstract：:Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in the world, with more than 100 million cases reported annually. While there have been extensive studies into the adverse effects that CT infection has on the female genital tract, and on the subsequent ability of these women to...

journal_title：Frontiers in immunology

authors： Redgrove KA,McLaughlin EA

更新日期：2014-10-27 00:00:00

abstract：:Cell signaling is an essential requirement for mammalian cell invasion by Trypanosoma cruzi. Depending on the parasite strain and the parasite developmental form, distinct signaling pathways may be induced. In this short review, we focus on the data coming from studies with metacyclic trypomastigotes (MT) generated in...

journal_title：Frontiers in immunology

authors： Maeda FY,Cortez C,Yoshida N

更新日期：2012-11-28 00:00:00

abstract：:Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we soug...

journal_title：Frontiers in immunology

authors： Mestre L,Carrillo-Salinas FJ,Mecha M,Feliú A,Espejo C,Álvarez-Cermeño JC,Villar LM,Guaza C

更新日期：2019-06-14 00:00:00

abstract：:Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specific antigens recognized by T cells that confer protective immunity and ...

journal_title：Frontiers in immunology

authors： James CA,Seshadri C

更新日期：2020-02-11 00:00:00

abstract：:Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can...

journal_title：Frontiers in immunology

authors： Pang YP,Casal Moura M,Thompson GE,Nelson DR,Hummel AM,Jenne DE,Emerling D,Volkmuth W,Robinson WH,Specks U

更新日期：2019-10-25 00:00:00

abstract：:While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by Trypanosoma cruzi was still poorly characterized. In order to understand...

journal_title：Frontiers in immunology

authors： Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV

更新日期：2018-11-05 00:00:00

abstract：:The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophag...

journal_title：Frontiers in immunology

authors： Jacquin E,Apetoh L

更新日期：2018-05-09 00:00:00

abstract：:Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) overexpression are associated with disease severity. In addition, BAFF promotes ...

journal_title：Frontiers in immunology

authors： Nascimento M,Huot-Marchand S,Gombault A,Panek C,Bourinet M,Fanny M,Savigny F,Schneider P,Le Bert M,Ryffel B,Riteau N,Quesniaux VFJ,Couillin I

更新日期：2020-07-29 00:00:00

abstract：:According to the "two-step model," the intrathymic generation of CD4⁺ regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25⁺Foxp3⁻ developmental intermediate. These precursors subsequently require cy...

journal_title：Frontiers in immunology

authors： Hinterberger M,Wirnsberger G,Klein L

更新日期：2011-07-25 00:00:00

abstract：:Adipose tissue performs immunoregulatory functions in addition to fat storage. Various T cells in different fat depots either help maintain metabolic homeostasis under healthy conditions or contribute to metabolic disorders in pathological conditions such as obesity, diabetes, cardiovascular diseases, or even cancer. ...

journal_title：Frontiers in immunology

authors： Wang Q,Wu H

更新日期：2018-10-30 00:00:00

abstract：:Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively and qualitatively in the elderly. However, the function of human B-1 cells, which play critical anti-microbial and housekeeping roles...

journal_title：Frontiers in immunology

authors： Rodriguez-Zhurbenko N,Quach TD,Hopkins TJ,Rothstein TL,Hernandez AM

更新日期：2019-03-19 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) play a crucial role in regulating the intestinal immune response during colitis. We previously revealed an essential role of MDSC in promoting TH17 cell polarization, which was found to be arginase-1 (Arg-1)-dependent; however, the underlying mechanism remains obscure. Here we r...

journal_title：Frontiers in immunology

authors： Ma Z,Zhen Y,Hu C,Yi H

更新日期：2020-04-22 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by r...

journal_title：Frontiers in immunology

authors： Mendoza-Coronel E,Ortega E

更新日期：2017-03-27 00:00:00

abstract：:The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate...

journal_title：Frontiers in immunology

authors： Iragavarapu-Charyulu V,Wojcikiewicz E,Urdaneta A

更新日期：2020-03-05 00:00:00

abstract：:Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD acti...

journal_title：Frontiers in immunology

authors： Nagar M,Tilvawala R,Thompson PR

更新日期：2019-02-19 00:00:00

abstract：:Human pathogen Campylobacter jejuni is a significant risk factor for the development of long-term intestinal dysfunction although the cellular and molecular mechanisms remain scantily defined. IL-23 is an emerging therapeutic target for the treatment of inflammatory intestinal diseases, however its role in C. jejuni-d...

journal_title：Frontiers in immunology

authors： Jing X,Korchagina AA,Shein SA,Muraoka WT,Koroleva E,Tumanov AV

更新日期：2021-01-06 00:00:00