当前位置： SCI文献检索 > Open Forum Infectious Diseases期刊下所有文献 > Role of HCV Viremia in Corroborated HCV Transmission Events Within Young Adult Injecting Partnerships.

Role of HCV Viremia in Corroborated HCV Transmission Events Within Young Adult Injecting Partnerships.

Abstract：

Background:Hepatitis C virus (HCV), a major cause of morbidity and mortality, is common and rising among young persons who inject drugs (PWID). Reducing the level of viremia may be an intervention, yet the impact of viremia on HCV transmission is unknown. Methods:We conducted a prospective study of injecting partnerships (Partner Study) of young adult (age < 30 years) PWID within the UFO Study, which enrolled those at risk for HCV or with seronegative viremic infection and up to 3 HCV RNA-positive regular injecting partners. We examined the level of HCV viremia and stage of infection in the HCV-positive partner in regression analyses of HCV transmission events that were corroborated via HCV phylogenetic linkage analyses. Results:We enrolled 69 at-risk/acutely infected PWID. There were 25 new HCV infections (incidence rate, 35.9 per 100 person-years; 95% confidence interval [CI], 24.3-53.2 per 100 person-years); 12/25 (48%) were phylogenetically linked to at least 1 partner. We found no association between the infected partner's quantitative level of HCV viremia and likely transmission in multivariate analyses (adjusted odds ratio [AOR], 0.90; 95% confidence interval [CI], 0.55-1.46); however, seronegative viremic infection in the infected partner was associated with increased transmission (AOR, 28.02; 95% CI, 5.61-139.95). Conclusions:The HCV viremia level was not associated with increased odds of transmission, yet acute HCV infection (seronegative viremic) was. Explanations include high-risk behavior during acute infection or missed fluctuations in viremia during acute infection. Both point to the need for frequent testing to detect new infection and attempt to prevent onward transmission.

journal_name

Open Forum Infect Dis

journal_title

Open forum infectious diseases

authors

Hahn JA,Tully DC,Evans JL,Morris MD,Briceno A,Bean DJ,Allen TM,Page K

doi

10.1093/ofid/ofz125

subject

Has Abstract

pub_date

2019-04-25 00:00:00

pages

ofz125

issue

4

issn

2328-8957

pii

ofz125

journal_volume

6

pub_type

杂志文章

相关文献

Open Forum Infectious Diseases文献大全
  • Hepatitis C Seroprevalence Among Consecutive Labor and Delivery Admissions in Two New York City Hospitals.

    abstract：Background:Rates of hepatitis C virus (HCV) among women of childbearing age have increased as a result of the opioid epidemic, especially in the nonurban white population. Recently updated US Preventative Services Task Force and Centers for Disease Control and Prevention guidance have recommended universal HCV screenin...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa514

    authors： Kushner T,Park C,Masand D,Wagner B,Grace M,Rosenbluth E,Rodriquez-Rivas C,de la Cruz H,Overbey J,Sperling R

    更新日期：2020-10-23 00:00:00

  • Risk Factors, Screening, and Treatment Challenges in Staphylococcus aureus Native Septic Arthritis.

    abstract：Background:Staphylococcus aureus is the most common cause of native septic arthritis. Few studies have characterized this disease during the US opioid epidemic. The role of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening in this disease has not been elucidated. We sought to identify risk factors and ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa593

    authors： Gobao VC,Alfishawy M,Smith C,Byers KE,Yassin M,Urish KL,Shah NB

    更新日期：2020-12-18 00:00:00

  • An Uncommon Site of Streptococcus pneumoniae Colonization Leading to Recurrent Pneumococcal Disease.

    abstract：:This report describes a case of relapsing pneumococcal peritonitis. The postulated source of infection was vaginal colonization and secondary adherence of pneumococci to an intrauterine contraceptive device. After immunization with a conjugate pneumococcal vaccine, her antibody levels were observed. She remained infec...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw257

    authors： Sendi P,Moser Schaub EM,Nirgianakis K,Hathaway LJ,Bittel P,Goldblatt D,Streit S

    更新日期：2016-12-07 00:00:00

  • Whole Genome Sequencing of Peruvian Klebsiella pneumoniae Identifies Novel Plasmid Vectors Bearing Carbapenem Resistance Gene NDM-1.

    abstract：Background:Klebsiella pneumoniae is a bacterial pathogen with increasing rates of resistance to carbapenem antibiotics, but the population structure and genetic drivers of carbapenem-resistant K pneumoniae (CRKP) remain underexplored in developing countries. Carbapenem-resistant K pneumoniae were recently introduced in...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa266

    authors： Roach D,Waalkes A,Abanto J,Zunt J,Cucho C,Soria J,Salipante SJ

    更新日期：2020-07-02 00:00:00

  • Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

    abstract：:Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw024

    authors： Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

    更新日期：2016-02-08 00:00:00

  • Mitochondrial Haplogroups as a Risk Factor for Herpes Zoster.

    abstract：: Background.  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine m...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw184

    authors： Levinson RT,Hulgan T,Kalams SA,Fessel JP,Samuels DC

    更新日期：2016-10-19 00:00:00

  • Antimicrobial Susceptibility Trends Observed in Urinary Pathogens Obtained From New York State.

    abstract：:International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy297

    authors： Rank EL,Lodise T,Avery L,Bankert E,Dobson E,Dumyati G,Hassett S,Keller M,Pearsall M,Lubowski T,Carreno JJ

    更新日期：2018-11-16 00:00:00

  • Comparative Outcomes of Adults Hospitalized With Seasonal Influenza A or B Virus Infection: Application of the 7-Category Ordinal Scale.

    abstract：Background:The objective of this study was to investigate the difference in disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome end points. Methods:A prospective, observational study was conducted over the 2016-2018 influenza seasons in a centr...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz053

    authors： Wang Y,Fan G,Horby P,Hayden F,Li Q,Wu Q,Zou X,Li H,Zhan Q,Wang C,Cao B,CAP-China Network.

    更新日期：2019-02-15 00:00:00

  • Far East Scarlet-Like Fever: A Review of the Epidemiology, Symptomatology, and Role of Superantigenic Toxin: Yersinia pseudotuberculosis-Derived Mitogen A.

    abstract：:Far East scarlet-like fever (FESLF) is a severe inflammatory disease that occurs sporadically and in outbreaks in Russia and Japan. Far East scarlet-like fever is caused by Yersinia pseudotubuclosis infection, an organism that typically causes self-limiting gastroenteritis in Europe. Studies suggest the ability of Far...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章,评审

    doi：10.1093/ofid/ofv202

    authors： Amphlett A

    更新日期：2015-12-17 00:00:00

  • Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection.

    abstract：:Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and int...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa383

    authors： Cai CW,Pinyakorn S,Kroon E,de Souza M,Colby DJ,Pankam T,Pattanachaiwit S,Ubolyam S,Rupert A,Lallemand P,Dewar R,Highbarger HC,Ananworanich J,Vasan S,Sereti I

    更新日期：2020-08-26 00:00:00

  • Real-time Communication With Health Care Providers Through an Online Respiratory Pathogen Laboratory Report.

    abstract：:We implemented a real-time report to distribute respiratory pathogen data for our 8-hospital system to anyone with an Internet connection and a web browser. Real-time access to accurate regional laboratory observation data during an epidemic influenza season can guide diagnostic and therapeutic strategies. ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy322

    authors： Christensen PA,Olsen RJ,Perez KK,Cernoch PL,Long SW

    更新日期：2018-11-30 00:00:00

  • Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial.

    abstract：Background:Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation. Methods:Treatment effects of edoxaban (30 mg), a direct ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa026

    authors： Baker JV,Wolfson J,Peterson T,Mooberry M,Gissel M,Mystakelis H,Henderson MW,Garcia-Myers K,Rhame FS,Schacker TW,Brummel-Ziedins KE,Sereti I,Key NS,Tracy RP

    更新日期：2020-02-01 00:00:00

  • Physician Decisions to Defer Antiretroviral Therapy in Key Populations: Implications for Reducing Human Immunodeficiency Virus Incidence and Mortality in Malaysia.

    abstract：BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw219

    authors： Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

    更新日期：2017-01-25 00:00:00

  • Learning Experiences Within Infectious Diseases Pharmacy Residency Programs in the United States: A Cross-Sectional Survey.

    abstract：Background:Pharmacists with residency training in infectious diseases (ID) optimize antimicrobial therapy outcomes in patients and support antimicrobial stewardship (AS) programs. Although most ID residencies are accredited and assessed by certain standards, the degree to which these programs are similar is not known. ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz387

    authors： Cho JC,Crotty MP,Kufel WD,Chahine EB,Sofjan AK,Gallagher JC,Estrada SJ

    更新日期：2019-09-06 00:00:00

  • Hepatitis C Elimination in People With HIV Is Contingent on Closing Gaps in the HIV Continuum.

    abstract：Background:Bolstered by the high efficacy of hepatitis C virus (HCV) treatment, the World Health Organization has called for HCV elimination by 2030. People with HIV (PWH) have been identified as a population in which elimination should be prioritized. Methods:We examined progress in HCV elimination through the HCV ca...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz426

    authors： Falade-Nwulia O,Sutcliffe CG,Mehta SH,Moon J,Chander G,Keruly J,Katzianer J,Thomas DL,Moore RD,Sulkowski MS

    更新日期：2019-09-30 00:00:00

  • The Effect of Shorter Treatment Regimens for Hepatitis C on Population Health and Under Fixed Budgets.

    abstract：Background:Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx267

    authors： Morgan JR,Kim AY,Naggie S,Linas BP

    更新日期：2017-12-08 00:00:00

  • Diagnosing diabetic foot osteomyelitis: narrative review and a suggested 2-step score-based diagnostic pathway for clinicians.

    abstract：:The diabetic foot infection remains a major cause of morbidity and mortality in many patients and remains a challenging diagnosis for most clinicians. Diagnosis is largely based on clinical signs supplemented by various imaging tests. Magnetic resonance imaging (MRI) is not readily available to many clinicians, and bo...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章,评审

    doi：10.1093/ofid/ofu060

    authors： Markanday A

    更新日期：2014-08-07 00:00:00

  • Antibiotic Treatment Versus No Treatment for Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Multicenter Randomized Trial.

    abstract：Background:Whether antibiotic treatment of asymptomatic bacteriuria (AB) can prevent acute graft pyelonephritis (AGP) in kidney transplant (KT) recipients has not been elucidated. Methods:In this multicenter, open-label, nonblinded, prospective, noninferiority, randomized controlled trial, we compared antibiotic treat...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz243

    authors： Sabé N,Oriol I,Melilli E,Manonelles A,Bestard O,Polo C,Los Arcos I,Perelló M,Garcia D,Riera L,Tebé C,Len Ò,Moreso F,Cruzado JM,Carratalà J

    更新日期：2019-05-21 00:00:00

  • The spread and control of norovirus outbreaks among hospitals in a region: a simulation model.

    abstract：BACKGROUND:Because hospitals in a region are connected via patient sharing, a norovirus outbreak in one hospital may spread to others. METHODS:We utilized our Regional Healthcare Ecosystem Analyst software to generate an agent-based model of all the acute care facilities in Orange County (OC), California and simulated...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofu030

    authors： Bartsch SM,Huang SS,Wong KF,Avery TR,Lee BY

    更新日期：2014-07-02 00:00:00

  • Misidentification of Burkholderia pseudomallei and Other Burkholderia Species From Pediatric Infections in Mexico.

    abstract：:Burkholderia pseudomallei and Burkholderia cepacia complex are poorly studied in Mexico. The genotypic analysis of 38 strains isolated from children with pneumonia were identified and showed that both Burkholderia groups were present in patients. From our results, it is plausible to suggest that new species are among ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz008

    authors： Meza-Radilla G,Mendez-Canarios A,Xicohtencatl-Cortes J,Escobedo-Guerra MR,Torres AG,Ibarra JA,Estrada-de Los Santos P

    更新日期：2019-01-18 00:00:00

  • Peritoneal Dialysis-Associated Peritonitis Caused by Mycobacterium abscessus in Children-A Case Report.

    abstract：:Peritoneal dialysis (PD)-associated peritonitis constitutes a major complication associated with the procedure. PD-associated peritonitis caused by nontuberculous mycobacteria, usually as a result of an infection related to the PD catheter, has been reported in adults and is associated with significant complications a...

    journal_title：Open forum infectious diseases

    pub_type：

    doi：10.1093/ofid/ofaa579

    authors： Imam O,Al-Zubaidi K,Janahi M,Imam A,Leghrouz B,Dobson S,Sundararaju S,Tsui KM,Hasan MR,Perez-Lopez A

    更新日期：2020-11-27 00:00:00

  • Perioperative Bacterial Contamination From Patients on Contact Precaution in Operating Room Environment.

    abstract：:We investigated the microbial burden on the operating room environment when patients on contact precautions for a multidrug-resistant pathogen received surgery. Our study demonstrated that the perioperative environment was contaminated with aerobic bacteria and methicillin-resistant Staphylococcus aureus (MRSA) after ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa508

    authors： Kanamori H,Rutala WA,Gergen MF,Weber DJ

    更新日期：2020-10-27 00:00:00

  • High Kynurenine:Tryptophan Ratio Is Associated With Liver Fibrosis in HIV-Monoinfected and HIV/Hepatitis C Virus-Coinfected Women.

    abstract：Background:Tryptophan catabolism, measured by the kynurenine:tryptophan (kyn/trp) ratio, is associated with gut microbiota alterations in people with HIV (PWH). We examined the association of the kyn/trp ratio with liver fibrosis in women with/without HIV infection. Methods:The plasma kyn/trp ratio was measured in 137...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz281

    authors： Kardashian A,Ma Y,Yin MT,Scherzer R,Nolan O,Aweeka F,Tien PC,Price JC

    更新日期：2019-06-11 00:00:00

  • Multiple-Dose Oral Fosfomycin for Treatment of Complicated Urinary Tract Infections in the Outpatient Setting.

    abstract：Background:Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment of complicated urinary tract infections (UTI). The purpose of this study was to characterize the patients, infections, drug susceptibilities, and outcomes of multiple-dose fosfomycin episodes for ou...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa034

    authors： Derington CG,Benavides N,Delate T,Fish DN

    更新日期：2020-01-29 00:00:00

  • Missed Visits Associated With Future Preexposure Prophylaxis (PrEP) Discontinuation Among PrEP Users in a Municipal Primary Care Health Network.

    abstract：Background:Maintaining retention in preexposure prophylaxis (PrEP) care among diverse patient populations will be needed to support PrEP's efficacy. We characterized patterns of PrEP care retention in a US municipal primary care health network and examined whether missed visits, a metric of care retention that is easy ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz101

    authors： Spinelli MA,Scott HM,Vittinghoff E,Liu AY,Gonzalez R,Morehead-Gee A,Gandhi M,Buchbinder SP

    更新日期：2019-02-26 00:00:00

  • Prognostic Role of Bacterial and Fungal Infections in Patients With Liver Cirrhosis With and Without Acute-on-Chronic Liver Failure: A Prospective 2-Center Study.

    abstract：Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa453

    authors： Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale P

    更新日期：2020-11-04 00:00:00

  • Public Awareness of Sepsis Is Low in Sweden.

    abstract：:Background.  Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods.  A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results.  A total of 1001 ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv161

    authors： Mellhammar L,Christensson B,Linder A

    更新日期：2015-10-26 00:00:00

  • Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians.

    abstract：Background:In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy068

    authors： Gundlapalli AV,Beekmann SE,Graham DR,Polgreen PM,Members of the Emerging Infections Network.

    更新日期：2018-04-23 00:00:00

  • ERRATUM.

    abstract：:[This corrects the article DOI: 10.1093/ofid/ofv111.]. ...

    journal_title：Open forum infectious diseases

    pub_type： 已发布勘误

    doi：10.1093/ofid/ofv132

    authors：

    更新日期：2015-09-04 00:00:00

  • Endothelial Dysfunction Is Related to Monocyte Activation in Antiretroviral-Treated People With HIV and HIV-Negative Adults in Kenya.

    abstract：Background:Residual monocyte activation may contribute to increased risk for endothelial dysfunction and subsequent atherosclerotic cardiovascular diseases (CVDs) among people with HIV (PWH) on antiretroviral therapy (ART). We examined the relationship between monocyte activation and endothelial activation in PWH in Ke...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa425

    authors： Temu TM,Polyak SJ,Zifodya JS,Wanjalla CN,Koethe JR,Masyuko S,Nyabiage J,Kinuthia J,Gervassi AL,Oyugi J,Page S,Farquhar C

    更新日期：2020-09-12 00:00:00