Abstract：
:Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher number and reactivity. In the present study, we performed a time-course experiment in mice to better analyze the lung impact of atmospheric ultrafine particles, with regard to the effects induced by fine particles collected on the same site. Trace element and PAH analysis demonstrated the almost similar chemical composition of both particle fractions. Mice were exposed intranasally to FF or UFP according to acute (10, 50 or 100 µg of PM) and repeated (10 µg of PM 3 times a week during 1 or 3 months) exposure protocols. More particle-laden macrophages and even greater chronic inflammation were observed in the UFP-exposed mice lungs. Histological analyses revealed that about 50% of lung tissues were damaged in mice exposed to UFP for three months versus only 35% in FF-exposed mice. These injuries were characterized by alveolar wall thickening, macrophage infiltrations, and cystic lesions. Taken together, these results strongly motivate the update of current regulations regarding ambient PM concentrations to include UFP and limit their emission.
journal_name
Int J Environ Res Public Healthauthors
Saleh Y,Antherieu S,Dusautoir R,Y Alleman L,Sotty J,De Sousa C,Platel A,Perdrix E,Riffault V,Fronval I,Nesslany F,Canivet L,Garçon G,Lo-Guidice JMdoi
10.3390/ijerph16071210subject
Has Abstractpub_date
2019-04-04 00:00:00issue
7eissn
1661-7827issn
1660-4601pii
ijerph16071210journal_volume
16pub_type
杂志文章abstract：:Background: Paediatric acute hematogenous osteomyelitis (AHOM) is a serious disease requiring early diagnosis and treatment. To review the clinical presentation, management and organisms responsible for AHOM, and to explore risk factors for complicated AHOM, a large cohort referring to a single center over a 6-year pe...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2017-05-04 00:00:00
abstract：:Social capital (SC) affects quality of life, sport behaviours and health in individual and community context. The aim was to analyse how sports activity (SA) contributes to SC accumulation in a post-transformation country. A combination of four longitudinal, nationwide datasets was used. Instrumental variable method w...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2020-07-21 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the face validity of the self-reported single item work ability with objectively measured heart rate reserve (%HRR) among blue-collar workers. METHODS:We utilized data from 127 blue-collar workers (Female = 53; Male = 74) aged 18-65 years from the cross-sectional "N...
journal_title：International journal of environmental research and public health
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更新日期：2014-05-16 00:00:00
abstract：:Many countries of the world, including Lithuania, are making an effort to reduce surface water pollution. State monitoring data show that almost 80% of the lakes in Lithuania have an increased amount of sludge. One of the reasons for this increase in sludge is an excessive amount of biogenic material in the water. It ...
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pub_type： 杂志文章
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更新日期：2019-11-25 00:00:00
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pub_type： 杂志文章
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更新日期：2018-04-08 00:00:00
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更新日期：2019-11-20 00:00:00
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更新日期：2020-01-29 00:00:00
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更新日期：2018-02-07 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,meta分析,评审
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更新日期：2014-04-23 00:00:00
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更新日期：2018-06-04 00:00:00
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更新日期：2013-05-10 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-12-20 00:00:00
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更新日期：2012-03-01 00:00:00
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更新日期：2018-03-10 00:00:00
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更新日期：2019-06-11 00:00:00
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更新日期：2018-11-12 00:00:00
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更新日期：2019-04-03 00:00:00
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更新日期：2018-04-06 00:00:00
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更新日期：2012-07-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2020-08-12 00:00:00
