Abstract:
:Benzene is a hematopoietic toxicant, and hematopoietic cells in bone marrow (BM) are one of the main targets for its action, especially hematopoietic stem cells (HSCs). Hypoxia-inducible factor-1α (HIF-1α) is associated with the metabolism and physiological functions of HSCs. We previously found that the mechanism of regulation of HIF-1α is involved in benzene-induced hematopoietic toxicity. In this study, chromatin immunoprecipitation sequencing (ChIP-Seq) technologies were used to analyze the genome-wide binding spectrum of HIF-1α in mouse BM cells, and specific HIF-1α target genes and pathways associated with benzene toxicity were screened and validated. By application of the ChIP-Seq technique, we identified target genes HIF-1α directly binds to and regulates. Forty-two differentially down-regulated genes containing the HIF-1α specific binding site hypoxia response element (HRE) were found, of which 25 genes were with biological function. Moreover, the enrichment analysis of signal pathways indicated that these genes were significantly enriched in the Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, the Fc epsilon RI signaling pathway, Pyrimidine metabolism, the T cell receptor signaling pathway, and Transcriptional misregulation in cancer. After verification, 11 genes involved in HSC self-renewal, cell cycle, differentiation, and apoptosis pathways were found to be significantly reduced, and may participate in benzene-induced hematotoxicity. Our study provides a new academic clue for the mechanism of benzene hematotoxicity.
journal_name
Int J Environ Res Public Healthauthors
Man Z,Meng X,Sun F,Pu Y,Xu K,Sun R,Zhang J,Yin L,Pu Ydoi
10.3390/ijerph15112531subject
Has Abstractpub_date
2018-11-12 00:00:00issue
11eissn
1661-7827issn
1660-4601pii
ijerph15112531journal_volume
15pub_type
杂志文章abstract::There are persistent disparities with regard to receipt of herpes zoster vaccine among elderly blacks, but no data is available regarding the public health or economic impact of these disparities. A decision tree was constructed with multiple Markov nodes in order to estimate the preventable cases of herpes zoster occ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15102128
更新日期:2018-09-27 00:00:00
abstract::This study investigated the effects of the proximity to city parks and the influence of residential greenness on children's emotional and behavioral problems. This cross-sectional study included 1,468 mothers of children (ages 4 to 6) who were residents of the city of Kaunas, Lithuania. The mothers and their children ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110706757
更新日期:2014-06-27 00:00:00
abstract::A laboratory study has been carried out on two soil layers (H[X] and H[Y]) located above a groundwater table in Yaounde, Cameroon (Central Africa). The main purpose of this study was to assess the retention potential or sorption kinetics of Escherichia coli and Salmonella sp. on these soil layers. For both soil layers...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph2005030009
更新日期:2005-12-01 00:00:00
abstract::The prevalence of work-related musculoskeletal symptoms (WRMSs) in different body parts for nursing assistants (NAs) working in nursing homes is currently unknown. The aim of this study was to determine the extent of WRMSs in nursing assistants and the factors associated with them. Four hundred and forty NAs from 52 n...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15020265
更新日期:2018-02-04 00:00:00
abstract::The exposure of humans to nano-and microplastic particles (NMPs) is an issue recognized as a potential health hazard by scientists, authorities, politics, non-governmental organizations and the general public. The concentration of NMPs in the environment is increasing concomitantly with global plastic production and t...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph17238832
更新日期:2020-11-27 00:00:00
abstract::The purpose of this study is to evaluate the differences in concentric isokinetic strength characteristics of the knee extensor and knee flexor musculature between international (IL) and non-international level (N-IL) soccer players. The second aim is to establish strength symmetry status in knee muscles for dominant ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18010035
更新日期:2020-12-23 00:00:00
abstract::Settlement is a complex process of adjustment for migrants and refugees. Drawing on recent research on the settlement experiences of Kiribati migrants and their families living in New Zealand, this article examines the role of housing as an influencer of the settlement and health of Kiribati migrants. Using qualitativ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14101237
更新日期:2017-10-17 00:00:00
abstract::Epidemiological evidence has shown an association between exposure to high temperatures and occupational injuries, an issue gaining importance with environmental change. The aim of this study was to better understand contributing risk factors and preventive actions based on personal experiences. Interviews were conduc...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17030846
更新日期:2020-01-29 00:00:00
abstract::Traditional foods contribute to the health and well-being of Indigenous Peoples. Many Indigenous Peoples within Canada have expressed a desire to consume more traditional foods; however, there are a number of barriers to doing so. Southern and urban communities face unique challenges associated with traditional food c...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17072214
更新日期:2020-03-26 00:00:00
abstract::Collaborative care models for treatment of depression and anxiety disorders in primary care have been shown to be effective. The aim of this study was to investigate at the municipal level to what extent investment in mental health personnel at primary care health centres in the study area is reflected in the costs an...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110908743
更新日期:2014-08-26 00:00:00
abstract::The non-opioid analgesic metamizole (dipyrone) is commonly used in Germany despite its narrow indications and market withdrawal from several countries. In this study we analyzed prescribing patterns of metamizole focusing on regional differences. The source of data was the "Information system for health care data" whi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17113892
更新日期:2020-05-30 00:00:00
abstract::The aim of this study was to analyze the distribution and effectiveness of the different types of smash in professional padel according to the area and direction of the strokes and the gender. Through systematic observation, 1.015 smashes from eight finals (four men's and four women's) of the professional matches were...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17197027
更新日期:2020-09-25 00:00:00
abstract::The COVID-19 pandemic continues to spread in countries around the world. The impact of this virus is very great on populations following the application of total and partial containment measures. Our study aims to study the psychological impact of total and partial containment applied in Algeria, on 23 March 2020, fol...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17103604
更新日期:2020-05-21 00:00:00
abstract::Exploring the coupling relationship between urban land and carbon emissions (CE) is one of the important premises for coordinating the urban development and the ecological environment. Due to the influence of the scale effect, a systematic evaluation of the CE at different scales will help to develop more reasonable s...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17103416
更新日期:2020-05-14 00:00:00
abstract::American Indian (AI) communities experience disproportionate exposure to stressors and health inequities including type 2 diabetes. Yet, we know little about the role of psychosocial stressors for AI diabetes-related health outcomes. We investigated associations between a range of stressors and psychological, behavior...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14091074
更新日期:2017-09-16 00:00:00
abstract::Cardiovascular diseases (CVDs) and diabetes (DM) are two interrelated conditions that have a heavy morbidity and mortality burden worldwide. Patients with the two conditions usually take multiple medicines and thus are more susceptible to medicine-related problems (MRPs). MRPs can occur at any stage of the treatment p...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13050479
更新日期:2016-05-09 00:00:00
abstract::Regular maintenance of non-communicable chronic diseases can constrain disease progression in diabetic and hypertensive patients. To identify the individual and social factors that are associated with positive health-seeking behaviors and regular maintenance of chronic diseases, we have conducted a follow up study in ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13121268
更新日期:2016-12-21 00:00:00
abstract::Although much research has been conducted on workaholism, its crossover effects remain uninvestigated, especially in the context of organizations. Based on the job demands-resources (JD-R) model of burnout and the conservation of resources (COR) theory, we established a dual-path structural model to examine the effect...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17217742
更新日期:2020-10-23 00:00:00
abstract::Childhood obesity is a serious issue in the U.S. While obesity is the result of a multitude of factors, a great deal of research has focused on children's dietary intake. While children's eating patterns vary throughout the week, not much else is known about weekday-weekend differences. Therefore, the current study ex...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15040720
更新日期:2018-04-11 00:00:00
abstract::Workplace bullying is a serious problem that hinders the provision of quality care services by seriously affecting their physical, psychological, and social health status. Workplace bullying experiences refer to verbal and nonverbal harassment, work-related harassment, and external threats. Workplace bullying response...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17197052
更新日期:2020-09-26 00:00:00
abstract::This paper presents findings from real life situations, a longitudinal single case study on the role of natural environments in nature-based rehabilitation (NBR) for individuals with stress-related mental disorders, at the Alnarp Rehabilitation Garden in Sweden. A sample of 43 former clients voluntarily participated i...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110707094
更新日期:2014-07-14 00:00:00
abstract::Awareness of the health risks of smoking is an important factor in predicting smoking-related behaviour; however, little is known about the knowledge of health risks in low-income countries such as India. The present study examined beliefs about the harms of smoking and the impact of health knowledge on intentions to ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph9020564
更新日期:2012-02-01 00:00:00
abstract::While working underground, miners are exposed to a number of risk factors that have a negative impact on their health and may be a cause of an increased mortality in miners. The aim of the study was to compare total and specific mortality in black coal miners with acknowledged coal-workers' pneumoconiosis (CWP) and wi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14030269
更新日期:2017-03-07 00:00:00
abstract::The effect that the physical characteristics of urban design have on the pedestrian's perceptions of safety is a fundamental aspect of city planning. This is particularly so with street crossings, where the pedestrian has to make a decision. This paper analyses how pedestrians are affected by number of traffic lanes, ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17228576
更新日期:2020-11-19 00:00:00
abstract::Hospital buildings in the UK are at particular risk to rising summer temperatures associated with climate change. Balancing the thermal needs of patients, staff, and visitors is a challenging, complex endeavour. A case study of the ultrasound area of the Royal Berkshire Hospital's Maternity and Gynaecology building is...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16183347
更新日期:2019-09-11 00:00:00
abstract::Mixed methods research has been increasingly recognized as a useful approach for describing and explaining complex issues in palliative care and end-of-life research. However, little is known about the use of this methodology in the field and the ways in which mixed methods studies have been reported. The purpose of t...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph17113853
更新日期:2020-05-29 00:00:00
abstract::Opioid abuse and misuse have led to an epidemic which is currently spreading worldwide. Since the number of opioid overdoses is still increasing, it is becoming obvious that current rather unsystematic approaches to tackle this health problem are not effective. This review suggests that fighting the opioid epidemic re...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph18010341
更新日期:2021-01-05 00:00:00
abstract::Open defecation (OD) is still a significant public health challenge worldwide. In Timor-Leste, where an estimated 20% of the population practiced OD in 2017, increasing access and use of improved sanitation facilities is a government priority. Community-led total sanitation (CLTS) has become a popular strategy to end ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18031013
更新日期:2021-01-24 00:00:00
abstract::Whereas the topic of the 'cultural sensitivity' of healthcare systems has been addressed extensively in the US and the UK, literature on the subject in most European countries, specifically looking at the situation of Roma, is still scarce. Drawing on qualitative research conducted mainly in the city of Barcelona unde...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15020377
更新日期:2018-02-22 00:00:00
abstract::Numerous studies have established that participation in regular physical activity provides physical, cognitive, and affective benefits to adolescents, but fewer studies have examined how athletic involvement might affect character, social, or religious developmental markers of psychosocial functioning. The purpose of ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17030686
更新日期:2020-01-21 00:00:00