Nuclear Deformation During Neutrophil Migration at Sites of Inflammation.

abstract：:Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in the world, with more than 100 million cases reported annually. While there have been extensive studies into the adverse effects that CT infection has on the female genital tract, and on the subsequent ability of these women to...

journal_title：Frontiers in immunology

authors： Redgrove KA,McLaughlin EA

更新日期：2014-10-27 00:00:00

abstract：:The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and cellular immunity, removal of apoptotic and dead cells, and engagement ...

journal_title：Frontiers in immunology

authors： Holers VM,Banda NK

更新日期：2018-05-28 00:00:00

abstract：:Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory dis...

journal_title：Frontiers in immunology

authors： Mylonas A,Conrad C

更新日期：2018-11-28 00:00:00

abstract：:Health-related quality of life (HRQoL) in common variable immunodeficiency diseases (CVID) was evaluated by different tools, which were mainly used to compare different schedules of immunoglobulins administration in cross-sectional or short-term longitudinal studies. We assessed the HRQoL and psychological status of C...

journal_title：Frontiers in immunology

authors： Tabolli S,Giannantoni P,Pulvirenti F,La Marra F,Granata G,Milito C,Quinti I

更新日期：2014-11-26 00:00:00

abstract：Background:Chagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A, or IL18 polymorphism p...

journal_title：Frontiers in immunology

authors： Gomes Dos Santos A,Watanabe EH,Ferreira DT,Oliveira J,Nakanishi ÉS,Oliveira CS,Bocchi E,Novaes CTG,Cruz F,Carvalho NB,Sato PK,Yamashiro-Kanashiro EH,Pontillo A,de Freitas VLT,Onuchic LF,Shikanai-Yasuda MA

更新日期：2020-10-22 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to lymphoid malignancies. The majority of NBS patients are identified with a homozygous five base pair deletion in the Nibrin (NBN) gene (c.657_661del5, p.K219fsX19) with a founder effect obse...

journal_title：Frontiers in immunology

authors： Sharapova SO,Pashchenko OE,Bondarenko AV,Vakhlyarskaya SS,Prokofjeva T,Fedorova AS,Savchak I,Mareika Y,Valiev TT,Popa A,Tuzankina IA,Vlasova EV,Sakovich IS,Polyakova EA,Rumiantseva NV,Naumchik IV,Kulyova SA,Aleshkevich

更新日期：2021-01-08 00:00:00

abstract：:The development of stable and long-circulating liposomes provides protection of the drug cargo from degradation and increases tumor drug delivery, leading to the design of liposome formulations with great potential in cancer therapy. However, despite the sound pharmacologic basis, many liposomal as well as other nanop...

journal_title：Frontiers in immunology

authors： La-Beck NM,Gabizon AA

更新日期：2017-04-06 00:00:00

abstract：Background:Allergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinic...

journal_title：Frontiers in immunology

authors： Ma TT,Cao MD,Yu RL,Shi HY,Yan WJ,Liu JG,Pan C,Sun J,Wei QY,Wang DY,Wei JF,Wang XY,Yin JS

更新日期：2020-11-24 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. Donor T cells also contribute to graft-versus-host disease (GVHD), a debilitating and potentially fatal complication. Nove...

journal_title：Frontiers in immunology

authors： Mammadli M,Huang W,Harris R,Sultana A,Cheng Y,Tong W,Pu J,Gentile T,Dsouza S,Yang Q,Bah A,August A,Karimi M

更新日期：2020-11-26 00:00:00

abstract：:Introduction: Aerobic exercise improves lung inflammation in acute lung injury (ALI), but its mechanism remains unknown. Neutrophil extracellular traps (NETs) play an important role in LPS-induced ALI, and a positive correlation exists between NET formation and proinflammatory macrophage polarization. This study inves...

journal_title：Frontiers in immunology

authors： Shi Y,Liu T,Nieman DC,Cui Y,Li F,Yang L,Shi H,Chen P

更新日期：2020-03-19 00:00:00

abstract：:This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...

journal_title：Frontiers in immunology

authors： Wang D,Jiang X,Teng S,Zhang Y,Liu Y,Li X,Li Y

更新日期：2019-05-08 00:00:00

abstract：:Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

journal_title：Frontiers in immunology

authors： Mattila JT,Thomas AC

更新日期：2014-10-09 00:00:00

abstract：:Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate thi...

journal_title：Frontiers in immunology

authors： Cai C,Koch B,Morikawa K,Suda G,Sakamoto N,Rueschenbaum S,Akhras S,Dietz J,Hildt E,Zeuzem S,Welsch C,Lange CM

更新日期：2018-04-12 00:00:00

abstract：:Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

journal_title：Frontiers in immunology

authors： Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

更新日期：2019-08-08 00:00:00

abstract：:Altered macrophage infiltration upon tissue damage results in inadequate healing due to inappropriate remodeling and stem cell recruitment and differentiation. We investigated in vivo whether cells of endothelial origin phenotypically change upon heterotopic ossification induction and whether infiltration of innate im...

journal_title：Frontiers in immunology

authors： Tirone M,Giovenzana A,Vallone A,Zordan P,Sormani M,Nicolosi PA,Meneveri R,Gigliotti CR,Spinelli AE,Bocciardi R,Ravazzolo R,Cifola I,Brunelli S

更新日期：2019-07-19 00:00:00

abstract：:In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in effector lymphocytes. Whereas NFATc1 is not expressed in plasma cells, ...

journal_title：Frontiers in immunology

authors： Muhammad K,Rudolf R,Pham DAT,Klein-Hessling S,Takata K,Matsushita N,Ellenrieder V,Kondo E,Serfling E

更新日期：2018-01-24 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collecte...

journal_title：Frontiers in immunology

authors： Feng J,Fan S,Sun Y,Zhang Z,Ren H,Li W,Cui L,Peng B,Ren X,Zhang W,Guan H,Wang J

更新日期：2020-07-29 00:00:00

abstract：:The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a significant proportion of renal transplant patients develop donor-specific antibodie...

journal_title：Frontiers in immunology

authors： Dahdal S,Saison C,Valette M,Bachy E,Pallet N,Lina B,Koenig A,Monneret G,Defrance T,Morelon E,Thaunat O

更新日期：2019-02-05 00:00:00

abstract：:Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the ...

journal_title：Frontiers in immunology

authors： Yin S,Yu J,Hu B,Lu C,Liu X,Gao X,Li W,Zhou L,Wang J,Wang D,Lu L,Wang L

更新日期：2018-09-12 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGvHD) is a major complication affecting 40-70% of all transplant patients, whereby the earliest and most frequent presentation is in the skin. MicroRNAs play a ...

journal_title：Frontiers in immunology

authors： Atarod S,Norden J,Bibby LA,Janin A,Ratajczak P,Lendrem C,Pearce KF,Wang XN,O'Reilly S,Van Laar JM,Collin M,Dickinson AM,Crossland RE

更新日期：2018-07-10 00:00:00

abstract：:Membranous nephropathy (MN), a common pathological type of adult nephrotic syndrome, is an antibody-mediated kidney disease. It is widely accepted now that MN is an immune-related disease that involves the whole immune system. In this study, we analyzed the T-cell receptor beta chain (TCRβ) repertoire of the circulati...

journal_title：Frontiers in immunology

authors： Zhang Y,Jin Y,Guan Z,Li H,Su Z,Xie C,Chen X,Liu X,Pan Y,Ye P,Zhang L,Kong Y,Luo W

更新日期：2020-03-10 00:00:00

abstract：:For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve pa...

journal_title：Frontiers in immunology

authors： Ghimire S,Weber D,Mavin E,Wang XN,Dickinson AM,Holler E

更新日期：2017-03-20 00:00:00

abstract：:Malaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is involved not only in...

journal_title：Frontiers in immunology

authors： Inoue S,Niikura M,Mineo S,Kobayashi F

更新日期：2013-08-29 00:00:00

abstract：:Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for the...

journal_title：Frontiers in immunology

authors： Klöss S,Chambron N,Gardlowski T,Weil S,Koch J,Esser R,Pogge von Strandmann E,Morgan MA,Arseniev L,Seitz O,Köhl U

更新日期：2015-11-02 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organi...

journal_title：Frontiers in immunology

authors： Tarifeño-Saldivia E,Aguilar A,Contreras D,Mercado L,Morales-Lange B,Márquez K,Henríquez A,Riquelme-Vidal C,Boltana S

更新日期：2018-06-05 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues ass...

journal_title：Frontiers in immunology

authors： Mancheño-Corvo P,Lopez-Santalla M,Menta R,DelaRosa O,Mulero F,Del Rio B,Ramirez C,Büscher D,Bueren JA,Lopez-Belmonte J,Dalemans W,Garin MI,Lombardo E

更新日期：2017-04-21 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

journal_title：Frontiers in immunology

authors： Messingham KN,Crowe TP,Fairley JA

更新日期：2019-10-04 00:00:00

abstract：:Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize antigens presented on M...

journal_title：Frontiers in immunology

authors： Accolla RS,Ramia E,Tedeschi A,Forlani G

更新日期：2019-07-30 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection disrupts immune functions, including that of cytotoxic CD8+ T-cells which are important mediators of immune response. While HCV cure aims to eliminate long term sequelae of infection, whether direct-acting antiviral (DAA) treatment results in immune reconstitution remains uncl...

journal_title：Frontiers in immunology

authors： Vranjkovic A,Deonarine F,Kaka S,Angel JB,Cooper CL,Crawley AM

更新日期：2019-08-13 00:00:00