Abstract:
:Membranous nephropathy (MN), a common pathological type of adult nephrotic syndrome, is an antibody-mediated kidney disease. It is widely accepted now that MN is an immune-related disease that involves the whole immune system. In this study, we analyzed the T-cell receptor beta chain (TCRβ) repertoire of the circulating T lymphocytes of MN patients and healthy controls using high-throughput sequencing. We compared multiple aspects of the TCRβ repertoire, including diversity and the Vβ and Jβ genes between MN patients and healthy controls, and we found that the diversities within the VJ cassette combination in the peripheral blood of MN patients were lower than in the healthy controls. We also found the TCRβ repertoire similarity between pre- and post-therapy could reflect the clinical outcome, and two Vβ genes in pre-therapy had the potential to predict the therapeutic effect. These findings indicated the potential of the TCRβ repertoire as non-invasive biomarkers for the prognosis prediction of MN. The characteristics of circulating T-lymphocyte repertoires shed light on MN detection, treatment, and surveillance.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Zhang Y,Jin Y,Guan Z,Li H,Su Z,Xie C,Chen X,Liu X,Pan Y,Ye P,Zhang L,Kong Y,Luo Wdoi
10.3389/fimmu.2020.00387subject
Has Abstractpub_date
2020-03-10 00:00:00pages
387issn
1664-3224journal_volume
11pub_type
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