Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells.

abstract：:Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis and to develop antiviral small molecules to treat infected ...

journal_title：Frontiers in immunology

authors： Nyanguile O

更新日期：2019-06-21 00:00:00

abstract：Introduction:C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isofo...

journal_title：Frontiers in immunology

authors： Thiele JR,Zeller J,Kiefer J,Braig D,Kreuzaler S,Lenz Y,Potempa LA,Grahammer F,Huber TB,Huber-Lang M,Bannasch H,Stark GB,Peter K,Eisenhardt SU

更新日期：2018-04-16 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:Allergic asthma is a chronic Th2 inflammatory disease of the lower airways affecting a growing number of people worldwide. The impact of infections and microbiota composition on allergic asthma has been investigated frequently. Until now, however, there have been few attempts to investigate the impact of asthma on the...

journal_title：Frontiers in immunology

authors： Machelart A,Potemberg G,Van Maele L,Demars A,Lagneaux M,De Trez C,Sabatel C,Bureau F,De Prins S,Percier P,Denis O,Jurion F,Romano M,Vanderwinden JM,Letesson JJ,Muraille E

更新日期：2018-08-10 00:00:00

abstract：:Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of rece...

journal_title：Frontiers in immunology

authors： Lin A,Loré K

更新日期：2017-12-11 00:00:00

abstract：:Natural killer (NK) cells have a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules is tightly controlled through the balance of a large repertoire of inhibitory and activating receptors...

journal_title：Frontiers in immunology

authors： Pfefferle A,Jacobs B,Haroun-Izquierdo A,Kveberg L,Sohlberg E,Malmberg KJ

更新日期：2020-05-12 00:00:00

abstract：:An important goal for personalized treatment is predicting response to a particular therapeutic. A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [anti-drug antibodies (ADA)], which are associated with a poorer clinical outcome. Here we set out to identif...

journal_title：Frontiers in immunology

authors： Magill L,Adriani M,Berthou V,Chen K,Gleizes A,Hacein-Bey-Abina S,Hincelin-Mery A,Mariette X,Pallardy M,Spindeldreher S,Szely N,Isenberg DA,Manson JJ,Jury EC,Mauri C

更新日期：2018-12-05 00:00:00

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs) have been found to be massively induced in TB patients as well in murine Mtb infection models. However, the interaction of mycobacteria with MDSCs and its role in TB infection is not well studied. Here, we investigated the role of Ca...

journal_title：Frontiers in immunology

authors： John V,Kotze LA,Ribechini E,Walzl G,Du Plessis N,Lutz MB

更新日期：2019-12-03 00:00:00

abstract：:Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells (Tregs). Targeted pharmacological modulation of this pathway with a smal...

journal_title：Frontiers in immunology

authors： Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

更新日期：2016-03-01 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:Many current vaccines are less immunogenic and less effective in elderly compared to younger adults due to age-related changes of the immune system. Most vaccines utilized in the elderly contain antigens, which the target population has had previous contact with due to previous vaccination or infection. Therefore, mos...

journal_title：Frontiers in immunology

authors： Weinberger B,Haks MC,de Paus RA,Ottenhoff THM,Bauer T,Grubeck-Loebenstein B

更新日期：2018-05-15 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis. Their roles in cellular signaling are mediated mostly by direct interactions with various rece...

journal_title：Frontiers in immunology

authors： Park HH

更新日期：2018-08-30 00:00:00

abstract：Purpose:In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with differ...

journal_title：Frontiers in immunology

authors： Freitas ARR,Donalisio MR

更新日期：2018-01-08 00:00:00

abstract：:Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations ...

journal_title：Frontiers in immunology

authors： Von Holle TA,Moody MA

更新日期：2019-06-25 00:00:00

abstract：:Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

journal_title：Frontiers in immunology

authors： Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

更新日期：2018-07-25 00:00:00

abstract：:Therapeutic approaches that engage immune cells to treat cancer are becoming increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid tumor types. Most of the current immunotherapies focus on manipulating T cells, however, the tumor microenvironment (TME) is abundantly infiltrate...

journal_title：Frontiers in immunology

authors： Clappaert EJ,Murgaski A,Van Damme H,Kiss M,Laoui D

更新日期：2018-10-08 00:00:00

abstract：:Type 2 diabetes is a metabolic disorder characterized by persistently elevated glucose levels. There is no effective treatment strategy for this condition, and it poses a massive economic burden globally. Schistosoma soluble egg antigen (SEA)-induced immunomodulatory mechanisms have been reported in the treatment of a...

journal_title：Frontiers in immunology

authors： Tang CL,Yu XH,Li Y,Zhang RH,Xie J,Liu ZM

更新日期：2019-06-26 00:00:00

abstract：Background:The immune regulatory properties of semaphorin3A (sema3A) (both innate and adaptive) are well established in many in vitro studies. The injection of sema3A into a mice model of rheumatoid arthritis was proven to be highly beneficial, both in attenuating clinical symptoms and in decreasing inflammatory mechan...

journal_title：Frontiers in immunology

authors： Bejar J,Kessler O,Sabag AD,Sabo E,Itzhak OB,Neufeld G,Vadasz Z

更新日期：2018-04-04 00:00:00

abstract：:Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC in an experimental m...

journal_title：Frontiers in immunology

authors： Maria ATJ,Rozier P,Fonteneau G,Sutra T,Maumus M,Toupet K,Cristol JP,Jorgensen C,Guilpain P,Noël D

更新日期：2018-12-21 00:00:00

abstract：:Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the reso...

journal_title：Frontiers in immunology

authors： Barnig C,Bezema T,Calder PC,Charloux A,Frossard N,Garssen J,Haworth O,Dilevskaya K,Levi-Schaffer F,Lonsdorfer E,Wauben M,Kraneveld AD,Te Velde AA

更新日期：2019-07-23 00:00:00

abstract：:M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

journal_title：Frontiers in immunology

authors： Mills CD

更新日期：2015-05-05 00:00:00

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Emerging and re-emerging viruses pose a significant public health challenge around the world, among which RNA viruses are the cause of many major outbreaks of infectious diseases. As one of the early lines of defense in the human immune system, RIG-I-like receptors (RLRs) play an important role as sentinels to thwart ...

journal_title：Frontiers in immunology

authors： Yong HY,Luo D

更新日期：2018-06-20 00:00:00

abstract：:Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and...

journal_title：Frontiers in immunology

authors： Yap XZ,Lundie RJ,Feng G,Pooley J,Beeson JG,O'Keeffe M

更新日期：2019-01-31 00:00:00

abstract：:In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them are considered as promising therapeutic targets. However, new pers...

journal_title：Frontiers in immunology

authors： Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

更新日期：2018-11-05 00:00:00

abstract：:Duck plague virus (DPV) is a representative pathogen transmitted among aquatic animals that causes gross lesions and immune inhibition in geese and ducks. The mechanism of organ tropism and innate immune evasion of DPV has not been completely deciphered due to a lack of cell models to study the innate immune manipulat...

journal_title：Frontiers in immunology

authors： Tian B,Cai D,He T,Deng L,Wu L,Wang M,Jia R,Zhu D,Liu M,Yang Q,Wu Y,Zhao X,Chen S,Zhang S,Huang J,Ou X,Mao S,Yu Y,Zhang L,Liu Y,Cheng A

更新日期：2020-01-28 00:00:00

abstract：:Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) caused by streptococcal as well as staphylococ...

journal_title：Frontiers in immunology

authors： Kale SD,Mehrkens BN,Stegman MM,Kastelberg B,Carnes H,McNeill RJ,Rizzo A,Karyala SV,Coutermarsh-Ott S,Fretz JA,Sun Y,Koff JL,Rajagopalan G

更新日期：2020-06-26 00:00:00

abstract：:To improve the efficacy of immunotherapy for cancer and autoimmune diseases, recent ongoing and completed clinical trials have focused on specific targets to redirect the immune network toward eradicating a variety of tumors and ameliorating the self-destructive process. In a previous review, both systemic immunomodul...

journal_title：Frontiers in immunology

authors： Kong YC,Flynn JC

更新日期：2014-05-16 00:00:00

abstract：:Human regulatory CD4+ T cells (Tregs) are potent immunosuppressive lymphocytes responsible for immune tolerance and homeostasis. Since the seminal reports identifying Tregs, vast research has been channeled into understanding their genesis, signature molecular markers, mechanisms of suppression, and role in disease. T...

journal_title：Frontiers in immunology

authors： Adair PR,Kim YC,Zhang AH,Yoon J,Scott DW

更新日期：2017-09-21 00:00:00