A Newly Isolated Carboxymethyl-Glucan (CM-G) Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats.

abstract：:The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK region, we investigated skeletal muscles of a mouse with the constitut...

journal_title：Frontiers in physiology

authors： van der Pijl RJ,Hudson B,Granzier-Nakajima T,Li F,Knottnerus AM,Smith J,Chung CS,Gotthardt M,Granzier HL,Ottenheijm CAC

更新日期：2020-05-29 00:00:00

abstract：:Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is ne...

journal_title：Frontiers in physiology

authors： Kim JD,Leyva S,Diano S

更新日期：2014-12-09 00:00:00

abstract：:Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of multiple diverse ion channels. K+ channels, the largest family of chann...

journal_title：Frontiers in physiology

authors： Malysz J,Petkov GV

更新日期：2020-09-16 00:00:00

abstract：:We present a novel approach to quantify heart rate variability (HRV) and the results of applying this approach to synthetic and original data sets. Our approach evaluates the periodicity of heart rate by calculating the transform of Relative Shannon Entropy, the maximum value of the RR interval periodogram, and the ma...

journal_title：Frontiers in physiology

authors： Thungtong A,Knoch MF,Jacono FJ,Dick TE,Loparo KA

更新日期：2018-06-19 00:00:00

abstract：:A number of years ago we reported that ventral Lateral Neurons (LNvs), which are essential in the control of rest-activity cycles in Drosophila, undergo circadian remodeling of their axonal projections. This structural plasticity gives rise to changes in the degree of connectivity, which could provide a means of trans...

journal_title：Frontiers in physiology

authors： Herrero A,Duhart JM,Ceriani MF

更新日期：2017-11-14 00:00:00

abstract：:Blood pressure regulation is a prime example of homeostatic regulation. However, some characteristics of the cardiovascular system better match a non-linear self-organized system than a homeostatic one. To determine whether blood pressure regulation is self-organized, we repeated the seminal demonstration of self-orga...

journal_title：Frontiers in physiology

authors： Fortrat JO,Levrard T,Courcinous S,Victor J

更新日期：2016-03-31 00:00:00

abstract：Background:Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endoth...

journal_title：Frontiers in physiology

authors： Khalaf M,Scott-Ward T,Causer A,Saynor Z,Shepherd A,Górecki D,Lewis A,Laight D,Shute J

更新日期：2020-07-29 00:00:00

abstract：:Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal mode...

journal_title：Frontiers in physiology

authors： Scaramuzzo G,Ball L,Pino F,Ricci L,Larsson A,Guérin C,Pelosi P,Perchiazzi G

更新日期：2020-03-12 00:00:00

abstract：:Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated the various effects...

journal_title：Frontiers in physiology

authors： Catala A,Youssef LA,Reisz JA,Dzieciatkowska M,Powers NE,Marchetti C,Karafin M,Zimring JC,Hudson KE,Hansen KC,Spitalnik SL,D'Alessandro A

更新日期：2020-04-30 00:00:00

abstract：:There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama (Lama glama), which seem to have developed efficient protective mechanisms to avoid maladaptation resulting from chronic hypoxia, such as a resistance to the devel...

journal_title：Frontiers in physiology

authors： López V,Moraga FA,Llanos AJ,Ebensperger G,Taborda MI,Uribe E

更新日期：2018-05-29 00:00:00

abstract：:The mouse is one of the most important model organisms for understanding human genetic function and disease. This includes characterization of the factors that influence energy expenditure and dysregulation of energy balance leading to obesity and its sequelae. Measuring energy metabolism in the mouse presents a chall...

journal_title：Frontiers in physiology

authors： Speakman JR

更新日期：2013-03-14 00:00:00

abstract：Context:Strength-endurance mainly depends on the power output, which is often expressed relative to the individual's maximal power capability (Pmax). However, an individual can develop the same power, but in different combinations of force and velocity (force-velocity condition). Also, at matched power output, changing...

journal_title：Frontiers in physiology

authors： Rivière JR,Peyrot N,Cross MR,Messonnier LA,Samozino P

更新日期：2020-10-09 00:00:00

abstract：:Abnormal flow patterns in the aortas of those with bicuspid aortic valves (BAVs) are increasingly recognized as important in the pathogenesis of aortic dilatation but pulmonary flow patterns in bicuspid pulmonary valves have not been studied. Bicuspid pulmonary valve disease is rare and a small numbers of case reports...

journal_title：Frontiers in physiology

authors： Bissell MM,Loudon M,Neubauer S,Myerson SG

更新日期：2017-05-31 00:00:00

abstract：:AF is a heterogeneous rhythm disorder that is related to a wide spectrum of etiologies and has broad clinical presentations. Mechanisms underlying AF are complex and remain incompletely understood despite extensive research. They associate interactions between triggers, substrate and modulators including ionic and ana...

journal_title：Frontiers in physiology

authors： Cheniti G,Vlachos K,Pambrun T,Hooks D,Frontera A,Takigawa M,Bourier F,Kitamura T,Lam A,Martin C,Dumas-Pommier C,Puyo S,Pillois X,Duchateau J,Klotz N,Denis A,Derval N,Jais P,Cochet H,Hocini M,Haissaguerre M,Sache

更新日期：2018-10-17 00:00:00

abstract：:Forced sustained swimming exercise at optimal speed enhances growth in many fish species, particularly through hypertrophy of the white skeletal muscle. The exact mechanism of this effect has not been resolved yet. To explore the role of cortisol, we first subjected wild-type zebrafish to an exercise protocol validate...

journal_title：Frontiers in physiology

authors： Palstra AP,Mendez S,Dirks RP,Schaaf MJM

更新日期：2019-01-14 00:00:00

abstract：:Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. While chorioamnionitis (CHORIO), is a leading cause of preterm birth, the precise mechanism linking prenatal brain injury and long-t...

journal_title：Frontiers in physiology

authors： Yellowhair TR,Newville JC,Noor S,Maxwell JR,Milligan ED,Robinson S,Jantzie LL

更新日期：2019-04-02 00:00:00

abstract：:Ticks and tick-borne pathogens affect health and welfare of companion animals worldwide, and some human tick-borne diseases are associated with exposure to domestic animals. Vaccines are the most environmentally friendly alternative to acaracides for the control of tick infestations, and to reduce the risk for tick-bo...

journal_title：Frontiers in physiology

authors： Contreras M,Villar M,de la Fuente J

更新日期：2019-07-26 00:00:00

abstract：:Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, h...

journal_title：Frontiers in physiology

authors： Satou R,Sato M,Kimura M,Ishizuka Y,Tazaki M,Sugihara N,Shibukawa Y

更新日期：2017-05-23 00:00:00

abstract：:Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability...

journal_title：Frontiers in physiology

authors： Ihlen EAF,van Schooten KS,Bruijn SM,Pijnappels M,van Dieën JH

更新日期：2017-08-29 00:00:00

abstract：Objective:Polycystin-1 (PC-1) is a protein encoded by the gene of polycystic kidney disease-1 (PKD-1). This study was designed to investigate the regulatory mechanisms of PC-1 on phenotypes of aortic vascular smooth muscle cells (VSMCs) and functions of extracellular matrix (ECM) in thoracic aortic dissection (TAD). M...

journal_title：Frontiers in physiology

authors： Zhang J,Liu F,He YB,Zhang W,Ma WR,Xing J,Wang LX

更新日期：2020-09-24 00:00:00

abstract：:Background: Periodontitis is a chronic inflammatory disease with a possible infectious component. Anemia of inflammation (AI) occurring in various chronic diseases alters the hemoglobin (Hb) concentration and iron status. Currently, the association between periodontitis and AI is still controversial. The aim of this s...

journal_title：Frontiers in physiology

authors： Wu D,Lin Z,Zhang S,Cao F,Liang D,Zhou X

更新日期：2020-01-31 00:00:00

abstract：:Alcoholic liver disease (ALD) encompasses hepatic steatosis, which may progress to alcoholic hepatitis, fibrosis, and cirrhosis. It remains a leading cause of morbidity and mortality in the US and worldwide. The severity of liver disease correlates with plasma levels of bacterial products in patients, and experimental...

journal_title：Frontiers in physiology

authors： Hartmann P,Chen WC,Schnabl B

更新日期：2012-10-11 00:00:00

abstract：:Before they develop competent endothermy, mammals and birds are sensitive to fluctuating temperature. It follows that early life thermal environment can trigger changes to the ontogeny of thermoregulatory control. At the ecological level, we have incomplete knowledge of how such responses affect temperature tolerance ...

journal_title：Frontiers in physiology

authors： Nord A,Giroud S

更新日期：2020-05-25 00:00:00

abstract：:Hepatocellular carcinomas (HCCs) have different etiology and heterogenic genomic alterations lead to high complexity. The molecular features of HCC have largely been studied by gene expression and proteome profiling focusing on the correlations between the expression of specific markers and clinical data. Integration ...

journal_title：Frontiers in physiology

authors： D'Alessandro LA,Meyer R,Klingmüller U

更新日期：2013-02-25 00:00:00

abstract：:The aim of this study was to analyze the relationship between alveolar bone deformation and β-catenin expression levels in response to the mechanical load changed by dental extraction in adult rats. Twenty-four male rats (Rattus norvegicus albinus), Wistar linage, at 2 months of age, were used. The right upper incisor...

journal_title：Frontiers in physiology

authors： Ferreira BC,Freire AR,Araujo R,do Amaral-Silva GK,Okamoto R,Prado FB,Rossi AC

更新日期：2020-06-05 00:00:00

abstract：:Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth mus...

journal_title：Frontiers in physiology

authors： Lauzon AM,Bates JH,Donovan G,Tawhai M,Sneyd J,Sanderson MJ

更新日期：2012-06-11 00:00:00

abstract：:Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities. Craniosynostosis of the metopic suture (interfrontal suture in mice) is an important but rare feature associated with GCPS. GCPS is caused by mu...

journal_title：Frontiers in physiology

authors： Veistinen L,Takatalo M,Tanimoto Y,Kesper DA,Vortkamp A,Rice DP

更新日期：2012-05-03 00:00:00

abstract：:Many studies have investigated the physiological response to microgravity in both astronauts and animals. However, while space agencies have sought to deploy more women on their missions; animal models rarely include females studies or comparisons between males and females. Therefore, we exposed adult female rats to 2...

journal_title：Frontiers in physiology

authors： Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:Recent findings strongly promoted the hypothesis that common pelvic gynecological diseases including endometriosis and ovarian neoplasia may develop de novo from ectopic endometrial-like glands and/or embryonic epithelial remnants. To verify the frequency, the anatomical localization and the phenotype of mis...

journal_title：Frontiers in physiology

authors： Bouquet de Jolinière J,Ayoubi JM,Lesec G,Validire P,Goguin A,Gianaroli L,Dubuisson JB,Feki A,Gogusev J

更新日期：2012-12-03 00:00:00

abstract：:Previous studies assessing effect of ischemia on ventricular repolarization are mostly directed toward patients with coronary artery disease (CAD); however, similar reports on cardiac syndrome X (CSX) are scarce. Whether microvascular dysfunction of CSX and ischemia induced by CAD produce comparable effect on ventricu...

journal_title：Frontiers in physiology

authors： Lutfi MF

更新日期：2016-09-21 00:00:00