Abstract:
:Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Lee SM,Yip TF,Yan S,Jin DY,Wei HL,Guo RT,Peiris JSMdoi
10.3389/fimmu.2018.00516subject
Has Abstractpub_date
2018-03-16 00:00:00pages
516issn
1664-3224journal_volume
9pub_type
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