Dynamics of Natural Killer Cells Cytotoxicity in Microwell Arrays with Connecting Channels.

abstract：:Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

journal_title：Frontiers in immunology

authors： Wilkinson RW,Leishman AJ

更新日期：2018-06-01 00:00:00

abstract：:The pathogenicity of group A Streptococcus (GAS) is mediated by direct bacterial invasivity and toxin-associated damage. Among the extracellular products, the exotoxin streptolysin O (SLO) is produced by almost all GAS strains. SLO is a pore forming toxin (PFT) hemolitically active and extremely toxic in vivo. Recent ...

journal_title：Frontiers in immunology

authors： Vita GM,De Simone G,Leboffe L,Montagnani F,Mariotti D,Di Bella S,Luzzati R,Gori A,Ascenzi P,di Masi A

更新日期：2020-12-08 00:00:00

abstract：:Under normal conditions our intestines are inhabited by trillions of diverse microorganisms composing the intestinal microbiota, which are mostly non-pathogenic anaerobic commensal bacteria vital for the maintenance of immune homeostasis. The composition and diversity of the intestinal microbiota can be disturbed by v...

journal_title：Frontiers in immunology

authors： Köhler N,Zeiser R

更新日期：2019-01-17 00:00:00

abstract：:The recently emerged SARS-CoV-2 causing the ongoing COVID-19 pandemic is particularly virulent in the elderly while children are largely spared. Here, we explored the potential role of cross-reactive immunity acquired from pediatric vaccinations and exposure to common human pathogens in the protection and pathology of...

journal_title：Frontiers in immunology

authors： Reche PA

更新日期：2020-10-16 00:00:00

abstract：:Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification and classification of HLA genes to assist with precision medicine efforts in disease and transplantation, the efficiency of these methods are impeded by the absence of adequately-characterized high-frequency HLA allele...

journal_title：Frontiers in immunology

authors： Suzuki S,Ranade S,Osaki K,Ito S,Shigenari A,Ohnuki Y,Oka A,Masuya A,Harting J,Baybayan P,Kitazume M,Sunaga J,Morishima S,Morishima Y,Inoko H,Kulski JK,Shiina T

更新日期：2018-10-04 00:00:00

abstract：:Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrate...

journal_title：Frontiers in immunology

authors： Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

更新日期：2018-09-11 00:00:00

abstract：:Background: Although immunotherapy has emerged as the "next generation" of cancer treatments, it has not yet been shown to be successful in the treatment of patients with prostate cancer, for whom therapeutic options remain limited to radiotherapy and androgen (hormone) deprivation therapy. Previous studies have shown...

journal_title：Frontiers in immunology

authors： Hood SP,Foulds GA,Imrie H,Reeder S,McArdle SEB,Khan M,Pockley AG

更新日期：2019-01-25 00:00:00

abstract：:Depression is considered a neuropsychiatric disease associated with various neuronal changes within specific brain regions. We previously reported that ginsenoside-Rg1, a potential neuroprotective agent extracted from ginseng, significantly alleviated depressive-like disorders induced by chronic stress in rats. Howeve...

journal_title：Frontiers in immunology

authors： Fan C,Song Q,Wang P,Li Y,Yang M,Yu SY

更新日期：2018-12-07 00:00:00

abstract：:Immunotherapy using checkpoint blockade has revolutionized cancer treatment, improving patient survival and quality of life. Nevertheless, the clinical outcomes of such immunotherapy are highly heterogeneous between patients. Depending on the cancer type, the patient response rates to this immunotherapy are limited to...

journal_title：Frontiers in immunology

authors： Chuang YC,Tseng JC,Huang LR,Huang CM,Huang CF,Chuang TH

更新日期：2020-05-29 00:00:00

abstract：:An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune respon...

journal_title：Frontiers in immunology

authors： López-Posadas R,Stürzl M,Atreya I,Neurath MF,Britzen-Laurent N

更新日期：2017-10-05 00:00:00

abstract：:Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and ...

journal_title：Frontiers in immunology

authors： Oliveira-Nascimento L,Massari P,Wetzler LM

更新日期：2012-04-18 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

journal_title：Frontiers in immunology

authors： Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

更新日期：2019-08-08 00:00:00

abstract：:The immune system plays a central role in cancer development, showing both anti-tumor and pro-tumor activities depending on the immune cell subsets and the disease context. While CD8 T cells are associated with a favorable outcome in most cancers, only T helper type 1 (Th1) CD4 T cells play a protective role, in contr...

journal_title：Frontiers in immunology

authors： Bohner P,Chevalier MF,Cesson V,Rodrigues-Dias SC,Dartiguenave F,Burruni R,Tawadros T,Valerio M,Lucca I,Nardelli-Haefliger D,Jichlinski P,Derré L

更新日期：2019-03-29 00:00:00

abstract：:Background: Critically ill patients, especially following trauma or extensive surgery, experience a systemic immune response, consisting of a pro-inflammatory as well as a counterbalancing anti-inflammatory response. Pro-inflammation is necessary for the initiation of homeostatic control and wound healing of the organ...

journal_title：Frontiers in immunology

authors： Tamulyte S,Kopplin J,Brenner T,Weigand MA,Uhle F

更新日期：2019-03-12 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00684.]. ...

journal_title：Frontiers in immunology

authors： Kaufmann SHE

更新日期：2019-06-06 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:Among interferon (IFN) inducible antiviral factors both tripartite motif-containing protein 22 (TRIM22) and class II transactivator (CIITA) share the capacity of repressing human immunodeficiency virus type 1 (HIV-1) proviral transcription. TRIM22 is constitutively expressed in a subset of U937 cell clones poorly perm...

journal_title：Frontiers in immunology

authors： Forlani G,Tosi G,Turrini F,Poli G,Vicenzi E,Accolla RS

更新日期：2017-05-15 00:00:00

abstract：:Attenuated vaccinia virus (VACV) vectors are considered prime vaccine candidates for use in immunotherapy of infectious disease. In spite of this, recent data show that the level of attenuation may hamper the efficient generation of protective CD8 T cells. This suggests that additional adjuvant-like activities may nee...

journal_title：Frontiers in immunology

authors： Zhao Y,Tahiliani V,Salek-Ardakani S,Croft M

更新日期：2012-11-08 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC3) have been detected in human decidua, where they play a role in the...

journal_title：Frontiers in immunology

authors： Pelosi A,Alicata C,Tumino N,Ingegnere T,Loiacono F,Mingari MC,Moretta L,Vacca P

更新日期：2020-02-06 00:00:00

abstract：:Ninety percent of those diagnosed with systemic lupus erythematosus are female, with peak incidence between the ages of 15 and 45, when women are most hormonally active. Despite significant research effort, the mechanisms underlying this sex bias remain unclear. We previously showed that a functional knockout of estro...

journal_title：Frontiers in immunology

authors： Cunningham MA,Wirth JR,Scott JL,Eudaly J,Collins EL,Gilkeson GS

更新日期：2016-02-15 00:00:00

abstract：:A growing number of diseases in humans, including trauma, certain cancers, and infection, are known to be associated with l-arginine deficiency. In addition, l-arginine must be supplemented by diet during pregnancy to aid fetal development. In conditions of l-arginine depletion, T cell proliferation is impaired. We ha...

journal_title：Frontiers in immunology

authors： Yu HR,Tsai CC,Chang LS,Huang HC,Cheng HH,Wang JY,Sheen JM,Kuo HC,Hsieh KS,Huang YH,Yang KD,Hsu TY

更新日期：2017-04-25 00:00:00

abstract：:The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong recruitment of mon...

journal_title：Frontiers in immunology

authors： Pellefigues C,Tang SC,Schmidt A,White RF,Lamiable O,Connor LM,Ruedl C,Dobrucki J,Le Gros G,Ronchese F

更新日期：2017-11-16 00:00:00

abstract：:Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

journal_title：Frontiers in immunology

authors： Korn T,Muschaweckh A

更新日期：2019-11-14 00:00:00

abstract：:Food allergy is an atopic disease that is caused by the immune system targeting harmless food antigens that can result in life-threatening anaphylaxis. As humans and microbes have co-evolved, inevitably commensal microbes have a tremendous impact on our health. As such, the gut with its enormous microbial richness ref...

journal_title：Frontiers in immunology

authors： Kreft L,Hoffmann C,Ohnmacht C

更新日期：2020-08-14 00:00:00

abstract：:Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

journal_title：Frontiers in immunology

authors： Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

更新日期：2019-01-15 00:00:00

abstract：:Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by CD4 T cell effect...

journal_title：Frontiers in immunology

authors： Maggioli MF,Palmer MV,Thacker TC,Vordermeier HM,McGill JL,Whelan AO,Larsen MH,Jacobs WR Jr,Waters WR

更新日期：2016-10-17 00:00:00

abstract：:The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription fact...

journal_title：Frontiers in immunology

authors： Brettingham-Moore KH,Taberlay PC,Holloway AF

更新日期：2015-09-29 00:00:00

abstract：:Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

journal_title：Frontiers in immunology

authors： Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

更新日期：2016-04-19 00:00:00

abstract：:Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues are indicative of a healthy or inflamed tissue, and the interactions of hyaluronan with immune cells can influence thei...

journal_title：Frontiers in immunology

authors： Lee-Sayer SS,Dong Y,Arif AA,Olsson M,Brown KL,Johnson P

更新日期：2015-04-14 00:00:00