Abstract:
BACKGROUND:Phthalates, a class of endocrine disruptors, have been demonstrated to accelerate loss of ovarian follicle pool via disrupting folliculogenesis, and lead to diminished ovarian reserve. However, human data are limited. Here, we aimed to examine whether urinary phthalate metabolites are correlated with markers of ovarian reserve among women attending a fertility clinic. METHODS:We measured eight phthalate metabolites in urine samples collected from 415 women seeking infertility treatment at the Reproductive Medicine Center of Tongji Hospital, Wuhan, China. Data on measures of ovarian reserve, as indicated by serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels, were retrieved retrospectively through electronic medical charts. Multivariate linear models were performed to estimate the associations of urinary phthalate metabolites and serum AMH and INHB. We further explored the potential nonlinearity of the relationships with restricted cubic spline analysis. RESULTS:Overall, we found largely null associations between urinary phthalate metabolites and serum AMH. The multivariable adjusted differences in serum INHB levels comparing the highest quartile of urinary MEHP to the lowest were - 18.29% (95% CI: - 31.89%, - 1.98%; P-trend = 0.04). Women in the second to fourth quartiles of MEOHP had a significant decrease of - 23.74% (95% CI: -35.85%, - 9.24%), - 19.91% (95% CI: -33.30%, - 3.82%) and - 20.23% (95% CI: -34.43%, - 2.96%), respectively, in INHB levels compared to the first quartile. In the spline analysis, we identified a nonlinear relationship between MEOHP exposure and serum INHB. CONCLUSIONS:We provided evidence for a negative association between urinary concentrations of certain phthalate metabolites and serum INHB levels, suggesting an adverse effect of phthalates exposure on growing antral follicles. Whether phthalates exposure at environmentally level will pose a risk for ovarian reserve needs further investigation.
journal_name
Reprod Healthjournal_title
Reproductive healthauthors
Du YY,Guo N,Wang YX,Hua X,Deng TR,Teng XM,Yao YC,Li YFdoi
10.1186/s12978-018-0469-8subject
Has Abstractpub_date
2018-02-23 00:00:00pages
33issue
1issn
1742-4755pii
10.1186/s12978-018-0469-8journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Worldwide, about 287 000 women die each year from mostly preventable complications related to pregnancy and childbirth. A disproportionately high number of these deaths occur in sub-Saharan Africa. The Abiye ('Safe Motherhood') project in the Ifedore Local Government Area (LGA) of Ondo-State of Nigeria aimed...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-11-8
更新日期:2014-01-20 00:00:00
abstract:BACKGROUND:While the relationship between hemoglobin (Hb) concentrations and pregnancy outcomes has been studied often, most reports have focused on a specific Hb cutoff used to define anemia. Fewer studies have evaluated pregnancy outcomes across the entire range of Hb values. Moreover, to date, most studies of the re...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-020-01006-6
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Adolescent pregnancy is a worldwide problem because of its health, social, economic and political repercussions on the globe. Even though the rates of adolescent pregnancy have declined over the decade, there is still unacceptably high rates especially in lower and middle-income countries including Ghana. Al...
journal_title:Reproductive health
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12978-019-0784-8
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Pakistan has one of the highest maternal mortality ratios worldwide at 276/100,000 live births and only 51% percent of women receive four or more ANC visits. This means that there are missed opportunities for almost half of the women who were not able to seek the recommended antenatal visits. In Thatta distr...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-020-00956-1
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Psychological factor alters fertility hormones and contributes to male infertility. Anxiety and depression are common manifestations of psychological distress. Cytochrome P-4501A1 (CYP1A1) metabolizes xenobiotics and fertility hormones that influence male fertility. The effect of CYP1A1 polymorphism on male ...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-016-0169-1
更新日期:2016-05-24 00:00:00
abstract:OBJECTIVE:Access to comprehensive and culturally appropriate reproductive life planning is essential to women's health. Although many strategies and tools exist, few are designed for longitudinal use or provide visual aids. Our objective is to present the Family Planning Quotient (FPQ) and Reproductive Life Index (RepL...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-019-0787-5
更新日期:2019-08-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Reproductive health
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12978-020-00926-7
更新日期:2020-05-26 00:00:00
abstract:BACKGROUND:The decreased reproductive capacity of men is an important factor contributing to infertility. Accumulating evidence has shown that Electromagnetic radiation potentially has negative effects on human health. However, whether radio frequency electromagnetic radiation (RF-EMR) affects the human reproductive sy...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-015-0062-3
更新日期:2015-08-04 00:00:00
abstract:BACKGROUND:The study aims to assess the discordance between self-reported and observed measures of mistreatment of women during childbirth in public health facilities in Uttar Pradesh, India, as well as correlates of these measures and their discordance. METHODS:Cross sectional data were collected through direct obser...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-017-0409-z
更新日期:2017-11-15 00:00:00
abstract:BACKGROUND:There have been few studies to examine antenatal predictors of incident postnatal depression, particularly in low- and middle-income countries (LMICs). The aim of this study was to investigate antenatal predictors of incident and persistent maternal depression in a rural Ethiopian community in order to infor...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-019-0690-0
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:Most women report negative experience about the symptoms of uterine leiomyoma (UL) in their lives, such as abnormal uterine bleeding and pelvic pain. Many studies have been conducted about efficacy of UL treatment, but little research has been performed about womens health related quality of life (HRQL). ME...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-11-10
更新日期:2014-01-30 00:00:00
abstract:BACKGROUND:Adolescents in the Latin American and Caribbean region continue to experience poor reproductive health outcomes, including high rates of first birth before the age of 20 years. Aggregate national level data fails to identify groups where progress is particularly poor. This paper explores how trends in adoles...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-018-0578-4
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:Prior research supports the notion that parents have the ability to influence their children's decisions regarding sexual behavior. Yet parent-based approaches to curbing teen pregnancy and STDs have been relatively unexplored. The Parents Speak Up National Campaign (PSUNC) is a multimedia campaign that atte...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-7-17
更新日期:2010-07-21 00:00:00
abstract:BACKGROUND:The increased incidence of sexually transmitted infections (STIs) in Brazil represents a significant public health issue. This issue has raised awareness among health authorities regarding the quality of condoms. In Brazil, male condoms need to be certified. The certification process evaluates in detail the ...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-016-0254-5
更新日期:2016-12-07 00:00:00
abstract::Surrogacy involves one woman (surrogate mother) carrying a child for another person/s (commissioning person/couple), based on a mutual agreement requiring the child to be handed over to the commissioning person/couple following birth. Reasons for seeking surrogacy include situations where a woman has non-functional or...
journal_title:Reproductive health
pub_type: 社论
doi:10.1186/1742-4755-5-9
更新日期:2008-11-04 00:00:00
abstract:BACKGROUND:Many women in Russia rely on abortion as a primary birth control method. Although refusal to use contraceptives, including condoms, may undermine public health efforts to decrease HIV sexual risk behaviors, few studies have investigated the risk factors associated with abortion among women at high risk for H...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-8-28
更新日期:2011-10-12 00:00:00
abstract:BACKGROUND:Pregnancy as one of the critical stages of life carries a high risk to the health of pregnant women. The amount of weight gained during pregnancy can affect the woman and her infant health immediately or in the future. The present study is conducted to design and explore the effectiveness of an educational i...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-019-0696-7
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Previous studies in developing countries suggest that a husband plays an influential role in a woman's contraceptive use. The influence of a husband/partner's healthcare decision making power on a woman's intention to use contraceptives in Mozambique has not been studied. The present study examined this rela...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-015-0010-2
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:After the 1968 United Nations International Conference on Human Rights, access to family planning services became a human right. Such a service is of central importance to women's empowerment and is empirically needed to provide adequate healthcare. For registered refugees and asylum seekers in Germany compl...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-020-00962-3
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Postpartum haemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and is a significant contributor to severe maternal morbidity and long-term disability. Carbetocin may be an underused uterotonic for prevention of PPH. A number of studies are being conducted that may challenge t...
journal_title:Reproductive health
pub_type: 杂志文章,评审
doi:10.1186/s12978-018-0529-0
更新日期:2018-06-22 00:00:00
abstract:BACKGROUND:A variety of different approaches to measuring contraceptive use have been used or proposed, either to assess current use or adherence over time, using subjective or objective measures. This paper reports an overview of approaches to measuring adherence to the oral contraceptive, intra-uterine device, sub-de...
journal_title:Reproductive health
pub_type: 信件,评审
doi:10.1186/s12978-018-0494-7
更新日期:2018-03-15 00:00:00
abstract:BACKGROUND:Recent evidence suggests that mistreatment of women during childbirth is a global challenge facing health care systems. This study seeks to explore the prevalence of mistreatment of women in public health facilities of Ethiopia, and identify associated factors. METHODS:A two-stage cross sectional sampling d...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-019-0781-y
更新日期:2019-08-27 00:00:00
abstract:BACKGROUND:Many patients use websites, blogs, or online social communities to gain health knowledge, information about disease symptoms, and disease diagnosis opinions. The purpose of this study is to use the online platform of blogs to explore whether the framing effect of information content, situated learning of inf...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-11-93
更新日期:2014-12-26 00:00:00
abstract:BACKGROUND:Although abortion is legally available in South Africa, barriers to access exist. Early medical abortion is available to women with a gestational age up to 63 days and timely access is essential. This study aimed to determine women's acceptability and ability to self-assess eligibility for early medical abor...
journal_title:Reproductive health
pub_type: 杂志文章,多中心研究
doi:10.1186/s12978-016-0160-x
更新日期:2016-04-16 00:00:00
abstract:BACKGROUND:The evidence regarding oral contraceptives and its effectiveness with concomitant ingestion of antibiotics is conflicting. Until evidence becomes clearer, patients should be aware of this possible interaction. The aim of this study was to assess the knowledge and the source of information about this interact...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-015-0037-4
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:Residential accommodation for expectant mothers adjacent to health facilities, known as maternity waiting homes (MWH), is an intervention designed to improve access to skilled deliveries in low-income countries like Zambia where the maternal mortality ratio is estimated at 398 deaths per 100,000 live births....
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-017-0328-z
更新日期:2017-05-30 00:00:00
abstract:BACKGROUND:Despite the vast literature examining disparities in medical care, little is known about racial/ethnic and mental health disparities in sexual health care. The objective of this study was to assess disparities in safe sex counseling and resultant behavior among a patient population at risk of negative sexual...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-9-35
更新日期:2012-12-31 00:00:00
abstract:BACKGROUND:To evaluate the feasibility of conducting a prospective study to measure self-managed medication abortion outcomes, and to collect preliminary data on safety and effectiveness of self-managed medication abortion, we recruited callers to accompaniment groups (volunteer networks that provide counselling throug...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-020-01016-4
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Intra-partum mistreatment by healthcare providers remains a global public health and human rights challenge. Adolescents, who are typically younger, poorer and less educated have been found to be disproportionately exposed to intra-partum mistreatment. In Ghana, maternal mortality remains a leading cause of ...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-020-00977-w
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Stringent donor-screening criteria and legislation prohibiting payment for donor gametes have contributed to the radical decline of donor insemination (DI) using sperm provided by Canadian men. Thus, many individuals rely on imported sperm. This paper examines the feasibility of an altruistic sperm donation ...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-016-0275-0
更新日期:2017-01-14 00:00:00