Abstract:
BACKGROUND:Postpartum haemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and is a significant contributor to severe maternal morbidity and long-term disability. Carbetocin may be an underused uterotonic for prevention of PPH. A number of studies are being conducted that may challenge the place of oxytocin as the first choice of uterotonics for prevention of PPH. This paper describes the current research into carbetocin and ranking of effectiveness of uterotonics that may provide important new information to assist healthcare decision makers to ensure that women receive an effective uterotonic for prevention of PPH. METHODS:We searched the WHO International Clinical Trials Registry Platform for current studies on effectiveness of carbetocin for prevention of PPH following vaginal delivery with sample sizes large enough to provide quality evidence to support potential changes to international guidelines. We also searched the Cochrane Library for current systematic reviews including carbetocin used in prevention of PPH. RESULTS:Susceptibility to degradation from exposure to heat is one of the key causes of reduced effectiveness of oxytocin in preventing PPH from uterine atony. Although heat stable and effective in preventing PPH, misoprostol is also subject to degradation due to exposure to moisture and produces some side-effects. Other uterotonics (including ergometrine and combinations of oxytocin, ergometrine and misoprostol) are also available and used with varying safety and effectiveness profiles and quality issues. Efforts to reduce maternal mortality from PPH include research studies seeking to identify safe, stable, effective uterotonics. Heat stable carbetocin is the subject of two major clinical studies into its effectiveness in preventing PPH following vaginal deliveries, information that could expand its application for prevention of PPH. CONCLUSION:Heat stable carbetocin is being investigated as a potential alternative to oxytocin. This paper describes two current clinical trials on carbetocin and a network meta-analysis ranking of all uterotonic agents, including carbetocin, which combined may provide evidence supporting expansion of the use of the heat stable formulation of carbetocin in PPH prevention.
journal_name
Reprod Healthjournal_title
Reproductive healthauthors
Theunissen FJ,Chinery L,Pujar YVdoi
10.1186/s12978-018-0529-0subject
Has Abstractpub_date
2018-06-22 00:00:00pages
94issue
Suppl 1issn
1742-4755pii
10.1186/s12978-018-0529-0journal_volume
15pub_type
杂志文章,评审abstract:BACKGROUND:As per the World Health Organization, the nutritional status of women of reproductive age is important, as effects of undernutrition are propagated to future generations. More than one-third of Indian women in the reproductive age group are in a state of chronic nutritional deficiency during the preconceptio...
journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-018-0535-2
更新日期:2018-06-22 00:00:00
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journal_title:Reproductive health
pub_type: 杂志文章
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更新日期:2017-05-30 00:00:00
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pub_type: 杂志文章
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journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-018-0555-y
更新日期:2018-06-27 00:00:00
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pub_type: 杂志文章
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journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/s12978-018-0583-7
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doi:10.1186/s12978-020-01010-w
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journal_title:Reproductive health
pub_type: 杂志文章,随机对照试验
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journal_title:Reproductive health
pub_type: 杂志文章
doi:10.1186/1742-4755-11-55
更新日期:2014-07-20 00:00:00
abstract:BACKGROUND:To find out about the prenatal diagnosis rate of myelomeningocele (MMC) by ultrasound scan in patients referred to the Children's Hospital Medical Center in Tehran, Iran from July 2004 to July 2005. METHODS:We included 140 children born with MMC and who were referred for management, surgery and treatment of...
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pub_type: 杂志文章
doi:10.1186/1742-4755-3-6
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1186/s12978-020-01006-6
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pub_type: 社论
doi:10.1186/1742-4755-5-9
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pub_type: 杂志文章
doi:10.1186/1742-4755-11-79
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pub_type: 杂志文章
doi:10.1186/1742-4755-8-1
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pub_type: 杂志文章
doi:10.1186/s12978-017-0417-z
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-10-27 00:00:00
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pub_type: 杂志文章
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更新日期:2019-11-08 00:00:00
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pub_type: 杂志文章
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journal_title:Reproductive health
pub_type: 杂志文章
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pub_type: 信件
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pub_type: 杂志文章
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