Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate.

Abstract:

:Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Kudlacek J,Chvojka J,Posusta A,Kovacova L,Hong SB,Weiss S,Volna K,Marusic P,Otahal J,Jiruska P

doi

10.3389/fneur.2017.00687

subject

Has Abstract

pub_date

2017-12-21 00:00:00

pages

687

issn

1664-2295

journal_volume

8

pub_type

杂志文章
  • Deciding Thrombolysis in AIS Based on Automated versus on WhatsApp Interpreted ASPECTS, a Reliability and Cost-Effectiveness Analysis in Developing System of Care.

    abstract::Background: Automated ASPECTS has the potential of reducing interobserver variability in the determination of early ischemic changes. We aimed to assess the performance of an automated ASPECTS vs. ASPECTS interpreted for sent CT images on WhatsApp and to correlate these results with the outcome. Materials and Methods:...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00333

    authors: Mansour OY,Ramadan I,Abdo A,Hamdi M,Eldeeb H,Marouf H,Elsalamawy D,Elfatatry A,Elnekidy A,Reda MI

    更新日期:2020-05-19 00:00:00

  • α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation.

    abstract:Background:Temporal lobe epilepsy (TLE) is one of the most drug-resistant types of epilepsy with about 80% of TLE patients falling into this category. Increasing evidence suggests that neuroinflammation, which has a critical role in the epileptogenesis of TLE, is associated with microglial activation. Therefore, agents...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00661

    authors: Liu HJ,Lai X,Xu Y,Miao JK,Li C,Liu JY,Hua YY,Ma Q,Chen Q

    更新日期:2017-12-14 00:00:00

  • Cognitive gains from gist reasoning training in adolescents with chronic-stage traumatic brain injury.

    abstract::Adolescents with traumatic brain injury (TBI) typically demonstrate good recovery of previously acquired skills. However, higher-order and later emergent cognitive functions are often impaired and linked to poor outcomes in academic and social/behavioral domains. Few control trials exist that test cognitive treatment ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00087

    authors: Cook LG,Chapman SB,Elliott AC,Evenson NN,Vinton K

    更新日期:2014-06-11 00:00:00

  • Exploring the Role of Temporoparietal Cortex in Upright Perception and the Link With Torsional Eye Position.

    abstract::Upright perception is a key aspect of orientation constancy, as we maintain a stable perception of the world despite continuous movements of our eyes, head, and body. Torsional position of the eyes can impact perception of upright by changing orientation of the images on the retina relative to gravity. Here, we invest...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00192

    authors: Otero-Millan J,Winnick A,Kheradmand A

    更新日期:2018-04-06 00:00:00

  • Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic.

    abstract::COVID-19 has rapidly become a pandemic emergency, distressing health systems in each affected country. COVID-19 determines the need for healthcare in a large number of people in an extremely short time and, like a tsunami wave, overruns emergency, infectious diseases, and pneumology departments as well as intensive ca...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00423

    authors: Bartolo M,Intiso D,Lentino C,Sandrini G,Paolucci S,Zampolini M,Board of the Italian Society of Neurological Rehabilitation (SIRN).

    更新日期:2020-04-30 00:00:00

  • Dual vs. Single Tasking During Circular Walking: What Better Reflects Progression in Parkinson's Disease?

    abstract::Background and Aim: Reliable, valid and sensitive measures of dual-task-associated impairments in patients with Parkinson's disease (PD) may reveal progressive deficits unnoticed under single-task walking. The aim of this study was to quantitatively identify markers of progressive gait deficits in idiopathic PD while ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00372

    authors: Micó-Amigo ME,Kingma I,Heinzel S,Nussbaum S,Heger T,van Lummel RC,Berg D,Maetzler W,van Dieën JH

    更新日期:2019-05-14 00:00:00

  • A Prospective Analysis of Lesion-Symptom Relationships in Acute Vestibular and Ocular Motor Stroke.

    abstract::Background: Diagnosing stroke as a cause of acute vertigo, dizziness, or double vision remains a challenge, because symptom characteristics can be variable. The purpose of this study was to prospectively investigate lesion-symptom relationships in patients with acute vestibular or ocular motor stroke. Methods: Three h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00822

    authors: Zwergal A,Möhwald K,Salazar López E,Hadzhikolev H,Brandt T,Jahn K,Dieterich M

    更新日期:2020-08-06 00:00:00

  • Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus Improves Patient Outcomes: A Nationwide Hospital-Based Survey in Japan.

    abstract::Background and Purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted a cross-sectional study using data from a nationwide epidemiological sur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00421

    authors: Nakajima M,Miyajima M,Ogino I,Akiba C,Kawamura K,Kurosawa M,Kuriyama N,Watanabe Y,Fukushima W,Mori E,Kato T,Sugano H,Karagiozov K,Arai H

    更新日期:2018-06-07 00:00:00

  • Higher Prevalence and Age Susceptibility of Intracranial Aneurysm in Patients With Acoustic Neuroma.

    abstract::Introduction: The purpose of this study was to verify whether the prevalence of intracranial aneurysm (IA) in patients with acoustic neuroma is greater than that in age- and sex-matched controls and to evaluate the independent risk factors related to the occurrence of IA. Methods: We retrospectively analyzed 231 patie...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.591526

    authors: You H,Bai Y,Yu T,Zeng T,Huang N,Mei W,Jiang C,Kang D,Wu X,Chen F

    更新日期:2020-11-02 00:00:00

  • Extracranial Trigger Site Surgery for Migraine: A Systematic Review With Meta-Analysis on Elimination of Headache Symptoms.

    abstract::Introduction: The headache phase of migraine could in selected cases potentially be treated by surgical decompression of one or more "trigger sites," located at frontal, temporal, nasal, and occipital sites. This systematic review with subsequent meta-analysis aims at critically evaluating the currently available evid...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00089

    authors: Vincent AJPE,van Hoogstraten WS,Maassen Van Den Brink A,van Rosmalen J,Bouwen BLJ

    更新日期:2019-02-14 00:00:00

  • Vestibular Dysfunction in Wernicke's Encephalopathy: Predominant Impairment of the Horizontal Semicircular Canals.

    abstract:Background:Wernicke's encephalopathy (WE), a metabolic disorder due to thiamine deficiency, manifests with various neurological symptoms and signs. It has been known as a cause of vestibular dysfunction. Preliminary reports have proposed predominant involvement of the horizontal semicircular canals (HSCs). Objective:T...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00141

    authors: Lee SH,Kim SH,Kim JM,Tarnutzer AA

    更新日期:2018-03-12 00:00:00

  • Resistant Hypertension after Hypertensive Intracerebral Hemorrhage Is Associated with More Medical Interventions and Longer Hospital Stays without Affecting Outcome.

    abstract:BACKGROUND:Hypertension (HTN) is the most common cause of spontaneous intracerebral hemorrhage (ICH). The aim of this study is to investigate the role of resistant HTN in patients with ICH. METHODS AND RESULTS:We conducted a retrospective study of all consecutive ICH admissions at our medical center from November 2013...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00184

    authors: Hong D,Stradling D,Dastur CK,Akbari Y,Groysman L,Al-Khoury L,Chen J,Small SL,Yu W

    更新日期:2017-05-03 00:00:00

  • Temporal Lobe Cavernous Malformation Caused Epileptic Amnesic Episodes and Mild Cognitive Impairment.

    abstract::Neuropathological features in Alzheimer's disease (AD) are amyloid β (Aβ) deposits and neurofibrillary changes. AD is characterized by memory impairment and cognitive dysfunction, with some reports associating these impairments with hyperexcitability caused by Aβ in the medial temporal lobe. Epileptic seizures are kno...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00620

    authors: Hirokawa Y,Fujimoto A,Ichikawa N,Sato K,Tanaka T,Enoki H,Otsuki Y,Okanishi T

    更新日期:2019-06-12 00:00:00

  • Early-Onset Parkinson's Disease Caused by PLA2G6 Compound Heterozygous Mutation, a Case Report and Literature Review.

    abstract::PLA2G6 has been certified as a causative gene in patients with autosomal recessive early-onset Parkinson's disease (EOPD). We reported an EOPD case caused by PLA2G6 gene mutation, and performed neurological examination, genetic analysis, and multimodal neuroimaging to describe this phenotype. A compound heterozygous m...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00915

    authors: Shen T,Hu J,Jiang Y,Zhao S,Lin C,Yin X,Yan Y,Pu J,Lai HY,Zhang B

    更新日期:2019-08-21 00:00:00

  • Protectiveness of Artesunate Given Prior Ischemic Cerebral Infarction Is Mediated by Increased Autophagy.

    abstract::Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis. The aim of this study is to explore the possible neuroprotective effects of artesunate ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00634

    authors: Shao M,Shen Y,Sun H,Meng D,Huo W,Qi X

    更新日期:2018-08-17 00:00:00

  • Conveniently-Grasped Field Assessment Stroke Triage (CG-FAST): A Modified Scale to Detect Large Vessel Occlusion Stroke.

    abstract::Background and Purpose: Patients with large vessel occlusion stroke (LVOS) need to be rapidly identified and transferred to comprehensive stroke centers (CSC). However, previous pre-hospital strategy remains challenging. We aimed to develop a modified scale to better predict LVOS. Methods: We retrospectively reviewed ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00390

    authors: Gong X,Chen Z,Shi F,Zhang M,Xu C,Zhang R,Lou M

    更新日期:2019-04-17 00:00:00

  • Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

    abstract::Objective: The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigate...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00636

    authors: Seo T,Shiraishi K,Kobayashi T,Fujita T,Saito K,Doi K

    更新日期:2018-08-03 00:00:00

  • Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning.

    abstract::Exposure of the brain to brief, non-harmful seizures can activate protective mechanisms that temporarily generate a damage-refractory state. This process, termed epileptic tolerance, is associated with large-scale down-regulation of gene expression. Polycomb group (PcG) proteins are master controllers of gene silencin...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2015.00046

    authors: Reynolds JP,Miller-Delaney SF,Jimenez-Mateos EM,Sano T,McKiernan RC,Simon RP,Henshall DC

    更新日期:2015-03-10 00:00:00

  • Medication Overuse Withdrawal in Children and Adolescents Does Not Always Improve Headache: A Cross-Sectional Study.

    abstract::Background: MOH can be diagnosed in subjects with headache occurring 15 days/month in association with a regular medication overuse, but its existence is not universally accepted. ICHD-3 redefined criteria for MOH, removing the criterion associating drug suspension with headache course. The aim of our study was to com...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00823

    authors: Moavero R,Stornelli M,Papetti L,Ursitti F,Ferilli MAN,Balestri M,Sforza G,Tarantino S,Vigevano F,Valeriani M

    更新日期:2020-08-19 00:00:00

  • Acute Seizures Occurring in Association With SARS-CoV-2.

    abstract::Seizures are an infrequent and serious neurological complication of SARS-CoV-2 infection, with limited data describing the etiology and the clinical context in which these occur or the associated electrographic and imaging findings. This series details four cases of seizures occurring in patients with COVID-19 with di...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.576329

    authors: Hwang ST,Ballout AA,Mirza U,Sonti AN,Husain A,Kirsch C,Kuzniecky R,Najjar S

    更新日期:2020-11-05 00:00:00

  • Association Between Peripapillary Bruch's Membrane Shape and Intracranial Pressure: Effect of Image Acquisition Pattern and Image Analysis Method, a Preliminary Study.

    abstract::Background/Aims: High intracranial pressure (ICP) is associated with changes in peripapillary Bruch's membrane (pBM) shape on optical coherence tomography (OCT) images of the optic nerve head. It is not known if image acquisition pattern and analysis method impact this association. Materials and Methods: Cross section...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.01137

    authors: Malhotra K,Patel MD,Shirazi Z,Moss HE

    更新日期:2018-12-21 00:00:00

  • Advanced Myoelectric Control for Robotic Hand-Assisted Training: Outcome from a Stroke Patient.

    abstract::A hand exoskeleton driven by myoelectric pattern recognition was designed for stroke rehabilitation. It detects and recognizes the user's motion intent based on electromyography (EMG) signals, and then helps the user to accomplish hand motions in real time. The hand exoskeleton can perform six kinds of motions, includ...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00107

    authors: Lu Z,Tong KY,Shin H,Li S,Zhou P

    更新日期:2017-03-20 00:00:00

  • Tradipitant in the Treatment of Motion Sickness: A Randomized, Double-Blind, Placebo-Controlled Study.

    abstract::Introduction: Novel therapies are needed for the treatment of motion sickness given the inadequate relief and bothersome and dangerous adverse effects of currently approved therapies. Neurokinin-1 (NK1) receptor antagonists have the potential to be effective in improving the symptoms of motion sickness, given the invo...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.563373

    authors: Polymeropoulos VM,Czeisler MÉ,Gibson MM,Anderson AA,Miglo J,Wang J,Xiao C,Polymeropoulos CM,Birznieks G,Polymeropoulos MH

    更新日期:2020-09-29 00:00:00

  • Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury.

    abstract::Inflammation after traumatic spinal cord injury (SCI) is non-resolving and thus still present in chronic injury stages. It plays a key role in the pathophysiology of SCI and has been associated with further neurodegeneration and development of neuropathic pain. Neural precursor cells (NPCs) have been shown to reduce t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00428

    authors: Riemann L,Younsi A,Scherer M,Zheng G,Skutella T,Unterberg AW,Zweckberger K

    更新日期:2018-06-08 00:00:00

  • Plasma Norepinephrine in Hypertensive Rats Reflects α(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited.

    abstract:UNLABELLED:α(2)-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Norepinephrine re-uptake-transporter effectively (NET) removes norepinephrine from the synapse. Overflow to plasma will therefore not reflect r...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00160

    authors: Berg T,Walaas SI,Roberg BÅ,Huynh TT,Jensen J

    更新日期:2012-11-08 00:00:00

  • Risk Factors of External Ventricular Drain Infection: Proposing a Model for Future Studies.

    abstract::Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this rev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00226

    authors: Sorinola A,Buki A,Sandor J,Czeiter E

    更新日期:2019-03-15 00:00:00

  • Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion Syndrome.

    abstract::Disrupted development of oropharyngeal structures as well as cranial nerve and brainstem circuits may lead to feeding and swallowing difficulties in children with 22q11. 2 deletion syndrome (22q11DS). We previously demonstrated aspiration-based dysphagia during early postnatal life in the LgDel mouse model of 22q11DS ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00004

    authors: Welby L,Caudill H,Yitsege G,Hamad A,Bunyak F,Zohn IE,Maynard T,LaMantia AS,Mendelowitz D,Lever TE

    更新日期:2020-01-31 00:00:00

  • The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions.

    abstract::Ischemic stroke is a multi-factorial cerebrovascular disease with high worldwide morbidity and mortality. In the past few years, multiple studies have revealed the underlying mechanism of ischemia/reperfusion injury, including calcium overload, amino acid toxicity, oxidative stress, and inflammation. Connexin 43 (Cx43...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00703

    authors: Liang Z,Wang X,Hao Y,Qiu L,Lou Y,Zhang Y,Ma D,Feng J

    更新日期:2020-07-31 00:00:00

  • Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis.

    abstract::Background: Increasing evidence implicates involvement of the innate immune system in the initiation and progression of Parkinson's disease (PD). Monocytes and monocyte-derived cells perform a number of functions, such as phagocytosis, chemotaxis, and cytokine secretion, which may be particularly relevant to PD pathol...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00870

    authors: Wijeyekoon RS,Kronenberg-Versteeg D,Scott KM,Hayat S,Jones JL,Clatworthy MR,Floto RA,Barker RA,Williams-Gray CH

    更新日期:2018-10-16 00:00:00

  • The Diagnostic Scope of Sensor-Based Gait Analysis in Atypical Parkinsonism: Further Observations.

    abstract::Background: Differentiating idiopathic Parkinson's disease (IPD) from atypical Parkinsonian disorders (APD) is challenging, especially in early disease stages. Postural instability and gait difficulty (PIGD) are substantial motor impairments of IPD and APD. Clinical evidence implies that patients with APD have larger ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00005

    authors: Gaßner H,Raccagni C,Eskofier BM,Klucken J,Wenning GK

    更新日期:2019-01-22 00:00:00