Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.

abstract：:Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Ch...

journal_title：Frontiers in pharmacology

authors： Yu B,Yuan B,Li J,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Fan Y,Pei X,Takagi N

更新日期：2020-07-17 00:00:00

abstract：:The objective of this study was to investigate the regulation of X-ray irradiation and its effect on the activity and protein and mRNA expression levels of CYP1A2 and CYP2E1 in rats. Rats were randomly divided into 0 Gy (control), 1 Gy (low-dose irradiation), and 5 Gy (high-dose irradiation) groups. CYP1A2 and CYP2E1 ...

journal_title：Frontiers in pharmacology

authors： Li XY,Qu N,Wang XJ,Yang JX,Xin YY,Zhu JB,Bai X,Duan YB

更新日期：2020-01-28 00:00:00

abstract：:Hypertension is a prevalent, complex, and polygenic cardiovascular disease, which is associated with increased mortality and morbidity. Across the world, traditional Chinese medicine (TCM) constituted by herbal medicine and non-pharmacological therapies is used to assist blood pressure management. Though widely accept...

journal_title：Frontiers in pharmacology

authors： Yang M,Lao L

更新日期：2019-03-08 00:00:00

abstract：:The inflammatory response to COVID-19 is specifically associated with an impaired type I interferon (IFN) response and complete blockade of IFN-β secretion. Clinically, nebulization of IFN-α-2b has been historically used in China to treat viral pneumonia associated with SARS-CoV. Very recent data show that the use of ...

journal_title：Frontiers in pharmacology

authors： Mary A,Hénaut L,Macq PY,Badoux L,Cappe A,Porée T,Eckes M,Dupont H,Brazier M

更新日期：2020-11-30 00:00:00

abstract：:It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. The present study explored the role and mechanisms of CGRP and CGRP recepto...

journal_title：Frontiers in pharmacology

authors： Hou KS,Wang LL,Wang HB,Fu FH,Yu LC

更新日期：2020-06-26 00:00:00

abstract：:Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal obesity, and combin...

journal_title：Frontiers in pharmacology

authors： Ma H,Zhang G,Mou C,Fu X,Chen Y

更新日期：2018-03-20 00:00:00

abstract：:Natural products (NPs) are an important source for new drug discovery over the past decades, which have been demonstrated to be effectively used in cancer prevention, treatment, and adjuvant therapy. Many methods, such as the genomic and metabolomic approaches, immunochemistry, mass spectrometry, and chromatography, h...

journal_title：Frontiers in pharmacology

authors： Yan T,Zeng Q,Wang L,Wang N,Cao H,Xu X,Chen X

更新日期：2019-11-28 00:00:00

abstract：:Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer ...

journal_title：Frontiers in pharmacology

authors： Campos JF,Espindola PPT,Torquato HFV,Vital WD,Justo GZ,Silva DB,Carollo CA,de Picoli Souza K,Paredes-Gamero EJ,Dos Santos EL

更新日期：2017-08-14 00:00:00

abstract：:Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

journal_title：Frontiers in pharmacology

authors： Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

更新日期：2020-04-22 00:00:00

abstract：:Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system - Ayurveda - it is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therape...

journal_title：Frontiers in pharmacology

authors： Balkrishna A,Thakur P,Varshney A

更新日期：2020-03-03 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：:Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat osteoclast-related bone diseases. Fumitremorgin C (Fum) is a mycotoxin...

journal_title：Frontiers in pharmacology

authors： Yuan Y,Chen K,Chen X,Wang C,Qiu H,Cao Z,Song D,Sun Y,Guo J,Tickner J,Xu J,Zou J

更新日期：2020-03-10 00:00:00

abstract：:The development of new medicines today, requires a multi-professional workforce, both in industry and the clinical research arena. Pharmaceutical physicians (PPs) and medicines development scientists (MDS) need a certain level of competence, achieved through on-the-job experience, with a postgraduate education foundat...

journal_title：Frontiers in pharmacology

authors： Imamura K,Criscuolo D,Jurczynska A,Kesselring G,Stonier P,Tsuda T,Silva H

更新日期：2019-03-05 00:00:00

abstract：:Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the pre...

journal_title：Frontiers in pharmacology

authors： de Freitas RCC,Bortolin RH,Lopes MB,Tamborlin L,Meneguello L,Silbiger VN,Hirata RDC,Hirata MH,Luchessi AD,Luchessi AD

更新日期：2017-12-12 00:00:00

abstract：:Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the an...

journal_title：Frontiers in pharmacology

authors： Li X,Xu H,Li C,Qiao G,Farooqi AA,Gedanken A,Liu X,Lin X

更新日期：2019-04-02 00:00:00

abstract：:Objective: Clinical trials are the source of evidence. ClinicalTrials.gov is valuable for analyzing current conditions. Until now, the state of drug interventions for heart infections is unknown. The purpose of this study was to comprehensively assess the characteristics of trials on cardiac-related infections and the...

journal_title：Frontiers in pharmacology

authors： Ma LL,Qiu Y,Song MN,Chen Y,Qu JX,Li BH,Zhao MJ,Liu XC

更新日期：2019-07-05 00:00:00

abstract：:Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and explored the underlyi...

journal_title：Frontiers in pharmacology

authors： Chen T,Wang Y,Zhang T,Zhang B,Chen L,Zhao L,Chen L

更新日期：2018-04-12 00:00:00

abstract：:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depen...

journal_title：Frontiers in pharmacology

authors： El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F

更新日期：2019-01-22 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or add...

journal_title：Frontiers in pharmacology

authors： He X,Fang J,Chen X,Zhao Z,Li Y,Meng Y,Huang L

更新日期：2019-10-30 00:00:00

abstract：:Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples....

journal_title：Frontiers in pharmacology

authors： Barrett MT,Lenkiewicz E,Evers L,Holley T,Ruiz C,Bubendorf L,Sekulic A,Ramanathan RK,Von Hoff DD

更新日期：2013-01-28 00:00:00

abstract：:Background: Little is known about the humanistic burden of small cell lung cancer (SCLC), specifically the impact on health-related quality of life (HRQoL). The aim of this systematic literature review was to explore the impact of SCLC on HRQoL and the patient reported outcomes (PROs) used to capture this impact. Meth...

journal_title：Frontiers in pharmacology

authors： Bennett BM,Wells JR,Panter C,Yuan Y,Penrod JR

更新日期：2017-06-15 00:00:00

abstract：:This article highlights several refractory oral diseases, such as stomatitis, burning mouth syndrome (BMS), glossalgia, atypical facial pain (AFP), oral cancer, dry mouth, and Sjögren's syndrome (SJS), in which use of Japanese herbal medicines, Kampo medicines (KM), on the basis of Kampo theory could exert the maximum...

journal_title：Frontiers in pharmacology

authors： Yamaguchi K

更新日期：2015-08-28 00:00:00

abstract：:Neurofibrillary pathology contributes to neuronal dysfunction and correlates with the clinical progression of Alzheimer's disease (AD). Tau phosphorylation is mainly regulated by a balance of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) activities. Cornel iridoid glycoside (CIG) is a main com...

journal_title：Frontiers in pharmacology

authors： Yang C,Li X,Gao W,Wang Q,Zhang L,Li Y,Li L,Zhang L

更新日期：2018-06-26 00:00:00

abstract：:Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system,...

journal_title：Frontiers in pharmacology

authors： Yadav E,Singh D,Yadav P,Verma A

更新日期：2018-05-23 00:00:00

abstract：:Cataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms involved in the devel...

journal_title：Frontiers in pharmacology

authors： Tewari D,Samoilă O,Gocan D,Mocan A,Moldovan C,Devkota HP,Atanasov AG,Zengin G,Echeverría J,Vodnar D,Szabo B,Crişan G

更新日期：2019-06-13 00:00:00

abstract：:The scaffold protein syntenin abounds during fetal life where it is important for developmental movements. In human adulthood, syntenin gain-of-function is increasingly associated with various cancers and poor prognosis. Depending on the cancer model analyzed, syntenin affects various signaling pathways. We previously...

journal_title：Frontiers in pharmacology

authors： Kashyap R,Roucourt B,Lembo F,Fares J,Carcavilla AM,Restouin A,Zimmermann P,Ghossoub R

更新日期：2015-10-21 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Zhao L,Hu C,Wang T,Lu J,Wu C,Chen L,Jin M,Hu H,Ji G,Cao Q,Jiang Y

更新日期：2020-02-28 00:00:00

abstract：:Paeoniflorin (PF) is the main active component of Paeonia lactiflora Pall., which is used in the treatment of severe cholestatic hepatitis. However, its biological mechanism in regulating bile acid metabolism and cholestatic liver injury has not been fully revealed. Our study aimed to reveal the mechanism of PF in the...

journal_title：Frontiers in pharmacology

authors： Wei S,Ma X,Niu M,Wang R,Yang T,Wang D,Wen J,Li H,Zhao Y

更新日期：2020-10-20 00:00:00

abstract：:Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...

journal_title：Frontiers in pharmacology

authors： da Costa RM,Rodrigues D,Pereira CA,Silva JF,Alves JV,Lobato NS,Tostes RC

更新日期：2019-04-12 00:00:00