The Humanistic Burden of Small Cell Lung Cancer (SCLC): A Systematic Review of Health-Related Quality of Life (HRQoL) Literature.

abstract：:The use of therapeutic peptides in various inflammatory diseases and autoimmune disorders has received considerable attention; however, the identification of anti-inflammatory peptides (AIPs) through wet-lab experimentation is expensive and often time consuming. Therefore, the development of novel computational method...

journal_title：Frontiers in pharmacology

authors： Manavalan B,Shin TH,Kim MO,Lee G

更新日期：2018-03-27 00:00:00

abstract：:Phosphorylation waves drive the propagation of signals generated in response to hormones and growth factors in target cells. cAMP is an ancient second messenger implicated in key biological functions. In mammals, most of the effects elicited by cAMP are mediated by protein kinase A (PKA). Activation of the kinase by c...

journal_title：Frontiers in pharmacology

authors： Rinaldi L,Sepe M,Donne RD,Feliciello A

更新日期：2015-09-04 00:00:00

abstract：:Literature is scarce on acute ischemia after intra-arterial injection of crushed tablets and no effective medical treatment against the progression of lesions is reported. The only factor able to modify the outcome is the delay between injection and management by a specialized vascular team. Moreover the risk of necro...

journal_title：Frontiers in pharmacology

authors： Détriché G,Goudot G,Khider L,Galloula A,Guillet M,Lillo-Le Louët A,Messas E,Mirault T

更新日期：2020-12-03 00:00:00

abstract：:High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumptio...

journal_title：Frontiers in pharmacology

authors： Lederer S,Dijkstra TMH,Heskes T

更新日期：2018-02-06 00:00:00

abstract：:Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. TP53 Mutation or dysfunction correlates with poor or no survival outcome in CPCs. Here, we report the case of a 4 month-old female who presented with dissemin...

journal_title：Frontiers in pharmacology

authors： Cornelius A,Foley J,Bond J,Nagulapally AB,Steinbrecher J,Hendricks WPD,Rich M,Yendrembam S,Bergendahl G,Trent JM,Sholler GS

更新日期：2017-09-25 00:00:00

abstract：:Background: Details of the extraction and purification procedure can have a profound impact on the composition of plant-derived extracts, and thus on their efficacy and safety. So far, studies with head-to-head comparison of the pharmacology of Ginkgo extracts rendered by different procedures have been rare. Objective...

journal_title：Frontiers in pharmacology

authors： Bader BM,Jügelt K,Schultz L,Schroeder OH

更新日期：2018-08-03 00:00:00

abstract：:Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate...

journal_title：Frontiers in pharmacology

authors： Saletti PG,Maior RS,Hori E,Nishijo H,Tomaz C

更新日期：2015-09-22 00:00:00

abstract：:Hypertensive disorders of pregnancy (HDP) are a group of morbid pregnancy complications, with preeclampsia (PE) being the most common subclassification among them. PE affects 2%-8% of pregnancies globally and threatens maternal and fetal health seriously. However, the only effective treatment of PE to date is the time...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Liu X,Yang L,Zou L

更新日期：2020-12-14 00:00:00

abstract：:In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation. Ang II acts on Ang II type 1 receptors promoting sodium retention and vaso...

journal_title：Frontiers in pharmacology

authors： Gonzalez AA,Gallardo M,Cespedes C,Vio CP

更新日期：2019-10-15 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：:Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

journal_title：Frontiers in pharmacology

authors： Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

更新日期：2020-08-12 00:00:00

abstract：Background:GuanXinNing tablet (GXNT), a traditional Chinese patent medicine, has been found to have remarkable antithrombotic effects and can effectively inhibit pro-thrombotic factors in previous studies. However, the mechanism of its antithrombotic effects remains little known. Methods:In this study, we first determ...

journal_title：Frontiers in pharmacology

authors： Wang ML,Yang QQ,Ying XH,Li YY,Wu YS,Shou QY,Ma QX,Zhu ZW,Chen ML

更新日期：2020-05-13 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till date, reports show...

journal_title：Frontiers in pharmacology

authors： Kouam AF,Yuan F,Njayou FN,He H,Tsayem RF,Oladejo BO,Song F,Moundipa PF,Gao GF

更新日期：2017-09-19 00:00:00

abstract：:Background: Metronomic chemotherapy (MC) is defined as the frequent administration of chemotherapy at doses below the maximal tolerated dose and with no prolonged drug-free break. MC has shown its efficacy in adult tumor types such as breast and ovarian cancer and has to some extent been studied in pediatrics. Objecti...

journal_title：Frontiers in pharmacology

authors： Verschuur A,Heng-Maillard MA,Dory-Lautrec P,Truillet R,Jouve E,Chastagner P,Leblond P,Aerts I,Honoré S,Entz-Werle N,Sirvent N,Gentet JC,Corradini N,André N

更新日期：2018-09-27 00:00:00

abstract：:Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells. If it can inhibit the activity of glycolysis-related enzymes and control the energy metabolism of tumor, it can be targeted for the treatment of malignant tu...

journal_title：Frontiers in pharmacology

authors： Wu ST,Liu B,Ai ZZ,Hong ZC,You PT,Wu HZ,Yang YF

更新日期：2020-03-27 00:00:00

abstract：:Genistein and icariin are flavonoid compounds that exhibit estrogen-like properties in inducing bone formation and reducing bone loss associated with estrogen deficiency in both preclinical and clinical studies. However, the mechanisms that are involved in mediating their estrogenic actions in bone cells are far from ...

journal_title：Frontiers in pharmacology

authors： Ho MX,Poon CC,Wong KC,Qiu ZC,Wong MS

更新日期：2018-05-11 00:00:00

abstract：:Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described - OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2), and OAT2 transcript variant 3 (OAT2-tv3). Early studies helping to define the liga...

journal_title：Frontiers in pharmacology

authors： Hotchkiss AG,Berrigan L,Pelis RM

更新日期：2015-10-06 00:00:00

abstract：:The foundations of innate immunity in neurodegenerative disorders were first laid by Del Rio Hortega (1919). He identified and named microglia, recognizing them as cells of mesodermal origin. Van Furth in 1969 elaborated the monocyte phagocytic system with microglia as the brain representatives. Validation of these co...

journal_title：Frontiers in pharmacology

authors： McGeer PL,McGeer EG

更新日期：2011-12-02 00:00:00

abstract：:Background: Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and compare the efficacy of different pharmacist based interventions on clinical outcomes of type 2 diabetes patients. Methods: A systematic search was ...

journal_title：Frontiers in pharmacology

authors： Bukhsh A,Khan TM,Lee SWH,Lee LH,Chan KG,Goh BH

更新日期：2018-04-10 00:00:00

abstract：:Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, histone post-translational modifications, and non-coding RNAs. Emergin...

journal_title：Frontiers in pharmacology

authors： Akone SH,Ntie-Kang F,Stuhldreier F,Ewonkem MB,Noah AM,Mouelle SEM,Müller R

更新日期：2020-08-13 00:00:00

abstract：:Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from 10% to over 30%, thus causing a...

journal_title：Frontiers in pharmacology

authors： Chang CJ,Chen CB,Hung SI,Ji C,Chung WH

更新日期：2020-07-02 00:00:00

abstract：:Βeta-cyclodextrin (β-CD) with a hydrophobic cavity enables the formation of inclusion complexes with organic molecules. The formation of host-guest complexes makes the application of β-CD popular in many fields, but their interaction with organisms is poorly understood. In the present study, the effect of β-CD on gut ...

journal_title：Frontiers in pharmacology

authors： Lv S,Zhang X,Feng Y,Jiang Q,Niu C,Yang Y,Wang X

更新日期：2021-01-14 00:00:00

abstract：:A leading cause of death worldwide is sepsis that develops as a dysregulated immune response to infection. Serious infection caused by methicillin-resistant Staphylococcus aureus (MRSA) increases the difficulty of treatment in septic patients. Host-directed therapy (HDT) is an emerging approach to bacterial infections...

journal_title：Frontiers in pharmacology

authors： Li T,Qian Y,Miao Z,Zheng P,Shi T,Jiang X,Pan L,Qian F,Yang G,An H,Zheng Y

更新日期：2020-02-21 00:00:00

abstract：:CLC-K channels belong to the CLC gene family, which comprises both Cl(-) channels and Cl(-)/H(+) antiporters. They form homodimers which additionally co-assemble with the small protein barttin. In the kidney, they are involved in NaCl reabsorption; in the inner ear they are important for endolymph production. Mutation...

journal_title：Frontiers in pharmacology

authors： Gradogna A,Pusch M

更新日期：2010-10-25 00:00:00

abstract：:Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a referen...

journal_title：Frontiers in pharmacology

authors： Wu G,Chen J,Hu X,Zhou H,Liu J,Lv D,Wu L,Shentu J

更新日期：2017-04-20 00:00:00

abstract：:Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

journal_title：Frontiers in pharmacology

authors： Boccia M,Vecchione F,Piccardi L,Guariglia C

更新日期：2017-07-25 00:00:00

abstract：:Fibrosis is a common, persistent and potentially debilitating complication of chemotherapy and radiation regimens used for the treatment of cancer. The molecular mechanisms underlying fibrosis have been well studied and reveal overall processes that are largely ubiquitous. However, it is important to note that althoug...

journal_title：Frontiers in pharmacology

authors： Mancini ML,Sonis ST

更新日期：2014-03-27 00:00:00

abstract：:In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania d...

journal_title：Frontiers in pharmacology

authors： Mahmoud AB,Danton O,Kaiser M,Khalid S,Hamburger M,Mäser P

更新日期：2020-08-14 00:00:00

abstract：:Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

journal_title：Frontiers in pharmacology

authors： Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

更新日期：2018-01-08 00:00:00

abstract：:Trichloroethylene (TCE) is a common volatile organic solvent which is considered as an ubiquitous environmental pollutant. It is claimed to be a developmental neurotoxicant. Our group evaluated previously its impact on three-dimensional neurospheres in vitro. The current work aims to investigate the neurotoxic effects...

journal_title：Frontiers in pharmacology

authors： Salama MM,El-Naggar DA,Abdel-Rahman RH,Elhak SAG

更新日期：2018-07-10 00:00:00