Gut Microbiota Combined With Metabolomics Reveals the Repeated Dose Oral Toxicity of β-Cyclodextrin in Mice.

abstract：:Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective nonprenylated compounds. In line with this, the natural prenylated isoflavonoid alpinumisoflavone (AIF) has been explored for a number of biological and pharmacological...

journal_title：Frontiers in pharmacology

authors： Ateba SB,Mvondo MA,Djiogue S,Zingué S,Krenn L,Njamen D

更新日期：2019-09-10 00:00:00

abstract：:Chinese formulas have been paid increasing attention in cancer multidisciplinary therapy due to their multi-targets and multi-substances property. Here, we aim to investigate the anti-breast cancer and chemosensitizing function of Ai Du Qing (ADQ) formula made up of Hedyotis diffusa, Curcuma zedoaria (Christm.) Rosc.,...

journal_title：Frontiers in pharmacology

authors： Wang N,Yang B,Zhang X,Wang S,Zheng Y,Li X,Liu S,Pan H,Li Y,Huang Z,Zhang F,Wang Z

更新日期：2018-10-02 00:00:00

abstract：:The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditions. Here we invest...

journal_title：Frontiers in pharmacology

authors： Steiner MA,Sciarretta C,Pasquali A,Jenck F

更新日期：2013-12-30 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：:Lapses in the graft-vs.-host disease (GVHD) prophylaxis and side effects of current standard care following allogeneic hematopoietic stem cell transplantation (allo-HSCT) call for novel regimens. Traditional approaches targeting T cells showed limited success in preventing acute GVHD (aGVHD). System medicine showed pr...

journal_title：Frontiers in pharmacology

authors： Lyu M,Zhou Z,Wang X,Lv H,Wang M,Pan G,Wang Y,Fan G,Gao X,Feng Y,Zhu Y

更新日期：2018-12-13 00:00:00

abstract：:6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

journal_title：Frontiers in pharmacology

authors： Cocchi V,Hrelia P,Lenzi M

更新日期：2020-08-18 00:00:00

abstract：:Background: Xuebijing injection (XBJ), transforming from Xuefuzhuyu decoction, is the only Chinese medicine injection approved for sepsis. XBJ and ulinastatin (UTI) combination therapy is supposed to be beneficial for sepsis patients. To fill the gap between the lack of evidence for the efficacy of combination therapy...

journal_title：Frontiers in pharmacology

authors： Chen G,Gao Y,Jiang Y,Yang F,Li S,Tan D,Ma Q

更新日期：2018-07-24 00:00:00

abstract：:Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the pre...

journal_title：Frontiers in pharmacology

authors： de Freitas RCC,Bortolin RH,Lopes MB,Tamborlin L,Meneguello L,Silbiger VN,Hirata RDC,Hirata MH,Luchessi AD,Luchessi AD

更新日期：2017-12-12 00:00:00

abstract：:Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene expression under normal and pathological conditions. Alterations in the expression and activation of histone methyltransferases (HMTs) have been reported in preclinical models of multiple kidney diseases, including acute kidney in...

journal_title：Frontiers in pharmacology

authors： Yu C,Zhuang S

更新日期：2019-12-06 00:00:00

abstract：:Pancreatic cancer decreases survival time and quality of life because of drug resistance and peripheral neuropathy during conventional treatment. This study was undertaken to investigate whether αvβ3 integrin receptor antagonist compounds NDAT and XT199 can suppress the development of cisplatin resistance and cisplati...

journal_title：Frontiers in pharmacology

authors： Debreli Coskun M,Sudha T,Bharali DJ,Celikler S,Davis PJ,Mousa SA

更新日期：2020-02-27 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:The clinical practice of selective serotonin reuptake inhibitor (SSRI) augmentation relies heavily on trial-and-error. Unfortunately, the drug combinations prescribed today fail to provide relief for many depressed patients. In order to identify potentially more effective treatments, we developed a computational model...

journal_title：Frontiers in pharmacology

authors： Camacho MB,Vijitbenjaronk WD,Anastasio TJ

更新日期：2019-10-25 00:00:00

abstract：:Mint [Mentha longifolia (L.) Hudson] is an aromatic plant that belongs to Lamiaceae family. It is traditionally used as herbal tea in Europe, Australia and North Africa and shows numerous pharmacological effects, such as spasmolytic, antioxidant, antimicrobial and anti-hemolytic. Recently, its antiproliferative role h...

journal_title：Frontiers in pharmacology

authors： Patti F,Palmioli A,Vitalini S,Bertazza L,Redaelli M,Zorzan M,Rubin B,Mian C,Bertolini C,Iacobone M,Armanini D,Barollo S,Airoldi C,Iriti M,Pezzani R

更新日期：2020-02-10 00:00:00

abstract：:There is growing evidence that the metabolic network is an integral regulator of cellular physiology. Dynamic changes in metabolite concentrations, metabolic flux, or network topology act as reporters of biological or environmental signals, and are required for the cell to trigger an appropriate biological reaction. C...

journal_title：Frontiers in pharmacology

authors： Ralser M,Michel S,Breitenbach M

更新日期：2012-03-08 00:00:00

abstract：:Positive links have been found between periodontitis and numerous diseases in humans via persistent inflammation throughout the body. However, the main factors responsible for maintaining this pro-inflammatory condition are poorly understood. The spleen, the largest secondary immune organ, is a central hub regulating ...

journal_title：Frontiers in pharmacology

authors： Dekita M,Wu Z,Ni J,Zhang X,Liu Y,Yan X,Nakanishi H,Takahashi I

更新日期：2017-07-17 00:00:00

abstract：:Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...

journal_title：Frontiers in pharmacology

authors： da Costa RM,Rodrigues D,Pereira CA,Silva JF,Alves JV,Lobato NS,Tostes RC

更新日期：2019-04-12 00:00:00

abstract：:The response to pazopanib in patients with metastatic renal cell carcinoma (mRCC) has been found to differ in Western and Eastern populations. Here, we analyzed the efficacy and side effects of pazopanib as first-line therapy in 31 consecutive patients with mRCC who were treated at a single Chinese center. Thirty-one ...

journal_title：Frontiers in pharmacology

authors： Wang B,Song JW,Chen HQ

更新日期：2020-10-29 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective endocrine drugs that block the growth of tumors and have no severe side effects is a challenge. Thereupon, synthetic steroids are promising therapeutic drugs for the t...

journal_title：Frontiers in pharmacology

authors： Scherbakov AM,Komkov AV,Komendantova AS,Yastrebova MA,Andreeva OE,Shirinian VZ,Hajra A,Zavarzin IV,Volkova YA

更新日期：2018-01-10 00:00:00

abstract：:The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

journal_title：Frontiers in pharmacology

authors： Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

更新日期：2017-07-11 00:00:00

abstract：:The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Here, we examined the regulation of tyrosine hydroxylase (TH) by tyramine and beta-phenylethylamine (β-PEA) compared to 3-iodot...

journal_title：Frontiers in pharmacology

authors： Zhang X,Mantas I,Alvarsson A,Yoshitake T,Shariatgorji M,Pereira M,Nilsson A,Kehr J,Andrén PE,Millan MJ,Chergui K,Svenningsson P

更新日期：2018-03-01 00:00:00

abstract：:Late-life depression is associated with significant cognitive impairment. Meta-analyses showed that depression is associated with an increased risk for Alzheimer's disease (AD) and it might be an etiological factor for AD. Since late-life depression is often connected with cognitive impairment and dementia is usually ...

journal_title：Frontiers in pharmacology

authors： Linnemann C,Lang UE

更新日期：2020-03-13 00:00:00

abstract：:Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management inc...

journal_title：Frontiers in pharmacology

authors： Jelin AC,O'Hare E,Blakemore K,Jelin EB,Valle D,Hoover-Fong J

更新日期：2017-03-06 00:00:00

abstract：:Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. Most of these patients with non-small cell lung cancer (NSCLC) present with the advanced stage of the disease at the time of diagnosis, and thus decrease the 5-year survival rate to about 5%. Immune checkpoint inhib...

journal_title：Frontiers in pharmacology

authors： Huang Z,Su W,Lu T,Wang Y,Dong Y,Qin Y,Liu D,Sun L,Jiao W

更新日期：2020-10-07 00:00:00

abstract：:The objective of the current project was to explore the pharmacotherapeutic role of Lavandula stoechas (L) for the management of dementia. Dementia is considered a global challenge of current century seeking special attention of pharmacologists to explore its best remedies. Methanolic extract of aerial parts of L. sto...

journal_title：Frontiers in pharmacology

authors： Mushtaq A,Anwar R,Ahmad M

更新日期：2018-11-23 00:00:00

abstract：:Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment exits for them; likely as result of the absence of neural markers associated to memory. Neurotransmitter systems and signaling pathways have been implicated in memory and dysfunctional memory; however, their role is poorly under...

journal_title：Frontiers in pharmacology

authors： Meneses A

更新日期：2015-07-21 00:00:00

abstract：:This study was aimed to investigate the effects of baicalin (BA), a major flavonoid constituent found in the herb Baikal skullcap, on dendritic cells (DCs). DCs were generated by culturing murine bone marrow (BM) cells for 6 days with granulocyte-macrophage colony-stimulating factor and interleukin (IL)-4, and lipopol...

journal_title：Frontiers in pharmacology

authors： Zhang H,Jiao Q,Gong Q,Zhang Y,Zhang W,Hu Z

更新日期：2011-03-29 00:00:00

abstract：:Pharmaceutical medicine has evolved to be a distinct medical scientific discipline over time. Pharmaceutical medicine has distinctive features related to complex innovative medicines development activities in an often commercially focused competitive environment. This sometimes uneasy mix of professionalism and commer...

journal_title：Frontiers in pharmacology

authors： Morris T,Brostoff JM,Stonier PD,Boyd A

更新日期：2020-01-15 00:00:00

abstract：:Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for effective drugs an urgent need. Neurodegeneration is triggered by the activation of several cellular processes, including oxidative stress, mitochondrial impairme...

journal_title：Frontiers in pharmacology

authors： de Souza JM,Goncalves BDC,Gomez MV,Vieira LB,Ribeiro FM

更新日期：2018-02-23 00:00:00

abstract：:Natural products (NPs) are an important source for new drug discovery over the past decades, which have been demonstrated to be effectively used in cancer prevention, treatment, and adjuvant therapy. Many methods, such as the genomic and metabolomic approaches, immunochemistry, mass spectrometry, and chromatography, h...

journal_title：Frontiers in pharmacology

authors： Yan T,Zeng Q,Wang L,Wang N,Cao H,Xu X,Chen X

更新日期：2019-11-28 00:00:00