A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica.

Abstract:

:The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested. The predominant phenolics were apigenin, luteolin, and quercetin in the tested extracts. Generally, the ethyl acetate and methanol extracts were noted as the most active in the antioxidant and enzyme inhibitory assays. Water extract with different concentrations indicated high level of DNA protection activity. Methanol and ethyl acetate extracts showed antibacterial effect against to Staphylococcus aureus and Staphylococcus epidermidis strains. The cytotoxic effects of O. natrix subsp. hispanica extracts on the survival of HeLa and PC3 cells were determined by MTT cell viability assay. Water and methanol extracts caused initiation of apoptosis for PC3 cell line. Furthermore, molecular docking was performed to better understand interactions between dominant phenolic compounds and selected enzymes. Our results clearly indicate that O. natrix subsp. hispanica could be considered a potential candidate for designing novel pharmaceuticals, cosmeceuticals and nutraceuticals.

journal_name

Front Pharmacol

authors

Yerlikaya S,Zengin G,Mollica A,Baloglu MC,Celik Altunoglu Y,Aktumsek A

doi

10.3389/fphar.2017.00600

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

600

issn

1663-9812

journal_volume

8

pub_type

杂志文章
  • Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect.

    abstract::The study under investigation focuses on in vitro antiproliferative efficacy of the flavonoid morin and the mechanisms by which it inhibits the growth of colon cancer using SW480 colon cancer cells with emphasis on Warburg effect. It was found that the cell proliferation was significantly inhibited by morin in a dose ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00640

    authors: Sithara T,Arun KB,Syama HP,Reshmitha TR,Nisha P

    更新日期:2017-09-12 00:00:00

  • Endocannabinoids: A Promising Impact for Traumatic Brain Injury.

    abstract::The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous liga...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00069

    authors: Schurman LD,Lichtman AH

    更新日期:2017-02-17 00:00:00

  • Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.

    abstract::Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00700

    authors: Massari CM,López-Cano M,Núñez F,Fernández-Dueñas V,Tasca CI,Ciruela F

    更新日期:2017-10-04 00:00:00

  • Warfarin and the Risk of Death, Stroke, and Major Bleeding in Patients With Atrial Fibrillation Receiving Hemodialysis: A Systematic Review and Meta-Analysis.

    abstract::Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01218

    authors: Lei H,Yu LT,Wang WN,Zhang SG

    更新日期:2018-11-06 00:00:00

  • Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus - A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies.

    abstract::Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system - Ayurveda - it is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therape...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00171

    authors: Balkrishna A,Thakur P,Varshney A

    更新日期:2020-03-03 00:00:00

  • Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells.

    abstract::G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified to regulate a variety of signaling molecules, among which may be a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00059

    authors: Palikhe S,Ohashi W,Sakamoto T,Hattori K,Kawakami M,Andoh T,Yamazaki H,Hattori Y

    更新日期:2019-02-04 00:00:00

  • Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux.

    abstract:Aims:SUMOylation is a post-translational modification that plays a crucial role in the cellular stress response. We aimed to demonstrate whether and how the SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Methods and Results:Adenovirus expressing Ubc9 was administrated by multipoint inje...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.561306

    authors: Xiao Q,Chen XH,Jiang RC,Chen SY,Chen KF,Zhu X,Zhang XL,Huang JJ,Qin Y,Zhang GP,Yi Q,Luo JD

    更新日期:2020-09-15 00:00:00

  • 4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling.

    abstract::Rheumatoid arthritis (RA) is a progressive autoimmune disease specific to synovial joints; it causes joint damage and other systemic abnormalities, thereby leading to physical disability and early mortality. Marine sponge-derived fungi, Pestalotiopsis sp., secrete immunosuppressive compounds in the culture broth. In t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00726

    authors: Lee JY,Kim GJ,Choi JK,Choi YA,Jeong NH,Park PH,Choi H,Kim SH

    更新日期:2018-07-20 00:00:00

  • Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer's Dementia Are Frequently Below the Recommended Levels.

    abstract:Background:Acetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia. They are widely used not only in Alzheimer's disease, but also in other forms of dementia. Efficacy of treatment might depend on serum concentration ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00691

    authors: Ortner M,Stange M,Schneider H,Schroeder C,Buerger K,Müller C,Dorn B,Goldhardt O,Diehl-Schmid J,Förstl H,Steimer W,Grimmer T

    更新日期:2020-05-21 00:00:00

  • Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of "Chronoconnectivity".

    abstract::In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated behaviors. Orexin neurons, which project widely to the neuraxis, a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.01061

    authors: Azeez IA,Del Gallo F,Cristino L,Bentivoglio M

    更新日期:2018-09-25 00:00:00

  • Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions.

    abstract::Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from 10% to over 30%, thus causing a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00969

    authors: Chang CJ,Chen CB,Hung SI,Ji C,Chung WH

    更新日期:2020-07-02 00:00:00

  • Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor-Dependent Lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice.

    abstract::Obesity is constantly rising into a major health threat worldwide. Activation of brown-like transdifferentiation of white adipocytes (browning) has been proposed as a promising molecular target for obesity treatment. In this study, we investigated the effect of ginsenoside Rb1 (Rb1), a saponin derived from Panax ginse...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01154

    authors: Lim S,Park J,Um JY

    更新日期:2019-10-15 00:00:00

  • Risk of Upper Gastrointestinal Bleeding in a Cohort of New Users of Low-Dose ASA for Secondary Prevention of Cardiovascular Outcomes.

    abstract::The Health Improvement Network UK primary care database was used to identify a cohort of 38 077 individuals aged 50-84 years with a first prescription of low-dose acetylsalicylic acid (ASA; 75-300 mg/day) for secondary prevention of cardiovascular or cerebrovascular events during 2000-2007. From this cohort, 169 incid...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2010.00126

    authors: Cea Soriano L,Rodríguez LA

    更新日期:2010-10-14 00:00:00

  • Potential Targeting of Renal Fibrosis in Diabetic Kidney Disease Using MicroRNAs.

    abstract::Diabetic kidney disease (DKD) is a major health problem and one of the leading causes of end-stage renal disease worldwide. Despite recent advances, there exists an urgent need for the development of new treatments for DKD. DKD is characterized by the excessive synthesis and deposition of extracellular matrix proteins...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.587689

    authors: Sakuma H,Hagiwara S,Kantharidis P,Gohda T,Suzuki Y

    更新日期:2020-11-13 00:00:00

  • Corrigendum: Improvement of Sepsis Prognosis by Ulinastatin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract::[This corrects the article DOI: 10.3389/fphar.2019.01370.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 已发布勘误

    doi:10.3389/fphar.2019.01697

    authors: Wang H,Liu B,Tang Y,Chang P,Yao L,Huang B,Lodato RF,Liu Z

    更新日期:2020-02-21 00:00:00

  • Screening and Identification of Cardioprotective Compounds From Wenxin Keli by Activity Index Approach and in vivo Zebrafish Model.

    abstract::Wenxin Keli (WXKL) is a widely used Chinese botanical drug for the treatment of arrhythmia, which is consisted of four herbs and amber. In the present study, we analyzed the chemical composition of WXKL using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) to tentatively identify 71 comp...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01288

    authors: Liu H,Chen X,Zhao X,Zhao B,Qian K,Shi Y,Baruscotti M,Wang Y

    更新日期:2018-11-13 00:00:00

  • Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape.

    abstract::The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effe...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00342

    authors: Sakhnevych SS,Yasinska IM,Fasler-Kan E,Sumbayev VV

    更新日期:2019-04-05 00:00:00

  • Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway.

    abstract::Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular endothelium (VE). The most principle mechanism might be excess reactive oxygen species (ROS) generation. Nevertheless, the characteristics of ROS generation, downstream mechanisms, and target organelles in Dox-induced endotheliotoxicit...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01531

    authors: He H,Wang L,Qiao Y,Zhou Q,Li H,Chen S,Yin D,Huang Q,He M

    更新日期:2020-01-10 00:00:00

  • Fusogenic Liposomes Increase the Antimicrobial Activity of Vancomycin Against Staphylococcus aureus Biofilm.

    abstract::Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01401

    authors: Scriboni AB,Couto VM,Ribeiro LNM,Freires IA,Groppo FC,de Paula E,Franz-Montan M,Cogo-Müller K

    更新日期:2019-11-29 00:00:00

  • Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone.

    abstract::Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the regulation of vascular tone remains unclear. The perspective that ET-1 plays little role in the on-going regulation of vascular tone at least under physiologic conditio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00517

    authors: Rapoport RM,Merkus D

    更新日期:2017-10-24 00:00:00

  • The Mechanisms of Traditional Chinese Medicine Underlying the Prevention and Treatment of Parkinson's Disease.

    abstract::Parkinson's disease (PD), characterized with bradykinesia, static tremor, rigidity and disturbances in balance, is the second most common neurodegenerative disorder. Along with the largely aging population in the world, the incidence is increasing year by year, which imposes the negative impacts on patients, their fam...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00634

    authors: Li X,Zhang Y,Wang Y,Xu J,Xin P,Meng Y,Wang Q,Kuang H

    更新日期:2017-09-19 00:00:00

  • Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.

    abstract::Advances in molecular pathology have changed the landscape of oncology. The ability to interrogate tissue samples for oncogene amplification, driver mutations, and other molecular alterations provides clinicians with an enormous level of detail about their patient's cancer. In some cases, this information informs trea...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2016.00327

    authors: Kersh AE,Sasaki M,Cooper LA,Kissick HT,Pollack BP

    更新日期:2016-09-26 00:00:00

  • The Effect of Pungent and Tingling Compounds from Piper nigrum L. on Background K+ Currents.

    abstract::Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00408

    authors: Beltrán LR,Dawid C,Beltrán M,Levermann J,Titt S,Thomas S,Pürschel V,Satalik M,Gisselmann G,Hofmann T,Hatt H

    更新日期:2017-06-26 00:00:00

  • UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic.

    abstract::Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00633

    authors: Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

    更新日期:2018-06-15 00:00:00

  • αvβ3 Integrin Antagonists Enhance Chemotherapy Response in an Orthotopic Pancreatic Cancer Model.

    abstract::Pancreatic cancer decreases survival time and quality of life because of drug resistance and peripheral neuropathy during conventional treatment. This study was undertaken to investigate whether αvβ3 integrin receptor antagonist compounds NDAT and XT199 can suppress the development of cisplatin resistance and cisplati...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00095

    authors: Debreli Coskun M,Sudha T,Bharali DJ,Celikler S,Davis PJ,Mousa SA

    更新日期:2020-02-27 00:00:00

  • Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice.

    abstract::γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in various diabetic mouse models. We propose that their combined administration can bring forth an additive therapeutic effect. We tested this...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00362

    authors: Liu W,Son DO,Lau HK,Zhou Y,Prud'homme GJ,Jin T,Wang Q

    更新日期:2017-06-20 00:00:00

  • Protective Effects of Anti-IL17 on Acute Lung Injury Induced by LPS in Mice.

    abstract::Introduction: T helper 17 (Th17) has been implicated in a variety of inflammatory lung and immune system diseases. However, little is known about the expression and biological role of IL-17 in acute lung injury (ALI). We investigated the mechanisms involved in the effect of anti-IL17 in a model of lipopolysaccharide (...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01021

    authors: Righetti RF,Dos Santos TM,Camargo LDN,Aristóteles LRCRB,Fukuzaki S,de Souza FCR,Santana FPR,de Agrela MVR,Cruz MM,Alonso-Vale MIC,Genaro IS,Saraiva-Romanholo BM,Leick EA,Martins MA,Prado CM,Tibério IFLC

    更新日期:2018-10-04 00:00:00

  • Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption.

    abstract::Osteoporosis is a common health problem worldwide caused by an imbalance of bone formation vs. bone resorption. However, current therapeutic approaches aimed at enhancing bone formation or suppressing bone resorption still have some limitations. In this study, we demonstrated for the first time that cepharanthine (CEP...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00210

    authors: Zhou CH,Meng JH,Yang YT,Hu B,Hong JQ,Lv ZT,Chen K,Heng BC,Jiang GY,Zhu J,Cheng ZH,Zhang W,Cao L,Wang W,Shen WL,Yan SG,Wu HB

    更新日期:2018-03-27 00:00:00

  • Montelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men.

    abstract::Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01094

    authors: Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

    更新日期:2019-09-24 00:00:00

  • CTRP5-Overexpression Attenuated Ischemia-Reperfusion Associated Heart Injuries and Improved Infarction Induced Heart Failure.

    abstract::Aims: C1q/tumor necrosis factor (TNF)-related protein 5 (CTRP5) belongs to the C1q/TNF-α related protein family and regulates glucose, lipid metabolism, and inflammation production. However, the roles of CTRP5 in ischemia/reperfusion (I/R) associated with cardiac injuries and heart failure (HF) needs to be elaborated....

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.603322

    authors: Peng M,Liu Y,Zhang XQ,Xu YW,Zhao YT,Yang HB

    更新日期:2020-12-22 00:00:00