Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology.

abstract：:Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local an...

journal_title：Frontiers in pharmacology

authors： Hua S

更新日期：2019-10-16 00:00:00

abstract：:There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

journal_title：Frontiers in pharmacology

authors： Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

更新日期：2019-10-09 00:00:00

abstract：INTRODUCTION:Nicotinic acetylcholine receptors are present in the cerebral white matter (WM). We hypothesized that WM response to nicotine can be detected by diffusion tensor imaging (DTI); and that such responses may be associated with nicotine-led cognitive enhancement in sustained attention. METHODS:A randomized, n...

journal_title：Frontiers in pharmacology

authors： Kochunov P,Du X,Moran LV,Sampath H,Wijtenburg SA,Yang Y,Rowland LM,Stein EA,Hong LE

更新日期：2013-09-18 00:00:00

abstract：:Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system,...

journal_title：Frontiers in pharmacology

authors： Yadav E,Singh D,Yadav P,Verma A

更新日期：2018-05-23 00:00:00

abstract：:Breast cancer (BC) is one of the most prevalent types of cancer worldwide with high morbidity and mortality rates. Treatment modalities include systemic therapy, in which chemotherapy is a major component in many cases. Several chemotherapeutic agents are used in combinations or as single agents with many adverse even...

journal_title：Frontiers in pharmacology

authors： Al-Mahayri ZN,Patrinos GP,Ali BR

更新日期：2020-04-15 00:00:00

abstract：:Impaired homeostasis of the carboxylic acids oxalate and citrate, dramatically increases the risk for the formation of Ca2+-oxalate kidney stones, which is the most common form of kidney stones in humans. Renal homeostasis of oxalate and citrate is controlled by complex mechanisms including epithelial transport protei...

journal_title：Frontiers in pharmacology

authors： Shimshilashvili L,Aharon S,Moe OW,Ohana E

更新日期：2020-04-07 00:00:00

abstract：:Osteoarthritis is one of the most common chronic health conditions associated with pain and disability. Advanced therapies based on mesenchymal stem cells have become valuable options for the treatment of these pathologies. Conditioned serum (CS, "Orthokine") has been used intra-articularly for osteoarthritic patients...

journal_title：Frontiers in pharmacology

authors： Blázquez R,Sánchez-Margallo FM,Reinecke J,Álvarez V,López E,Marinaro F,Casado JG

更新日期：2019-06-28 00:00:00

abstract：:Inborn cardiac diseases are among the most frequent congenital anomalies and are the main cause of death in infants within the first year of age in industrialized countries when not adequately treated. They can be divided into simple and complex cardiac malformations. The former ones, for instance atrial and ventricul...

journal_title：Frontiers in pharmacology

authors： Salameh A,Blanke K,Daehnert I

更新日期：2013-06-03 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19-25 nucleotides that are involved in regulating a range of developmental and physiological processes. Non-exosomal circulating and exosomal miRNAs have also been proposed to be useful in diagnostics as biomarkers for diseases and different ty...

journal_title：Frontiers in pharmacology

authors： Nik Mohamed Kamal NNSB,Shahidan WNS

更新日期：2020-01-20 00:00:00

abstract：:Cataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms involved in the devel...

journal_title：Frontiers in pharmacology

authors： Tewari D,Samoilă O,Gocan D,Mocan A,Moldovan C,Devkota HP,Atanasov AG,Zengin G,Echeverría J,Vodnar D,Szabo B,Crişan G

更新日期：2019-06-13 00:00:00

abstract：Objective:To explore the role of pharmacists and innovation of pharmacy interventions for COVID-19 patients in China. Methods:We comprehensively searched PubMed and Chinese databases Sinomed, China National Knowledge Infrastructure to identify articles reporting pharmacist interventions and pharmacy services for COVID...

journal_title：Frontiers in pharmacology

authors： Yi ZM,Hu Y,Wang GR,Zhao RS

更新日期：2020-10-02 00:00:00

abstract：:Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-orientated, single target, and conventional antidepressants are insufficient and far from ideal. Traditional Chinese Medicine (TCM) has historically been used to treat depression up till today, particularly in Asia. Its holistic, ...

journal_title：Frontiers in pharmacology

authors： Li C,Huang J,Cheng YC,Zhang YW

更新日期：2020-05-07 00:00:00

abstract：Background:Acetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia. They are widely used not only in Alzheimer's disease, but also in other forms of dementia. Efficacy of treatment might depend on serum concentration ...

journal_title：Frontiers in pharmacology

authors： Ortner M,Stange M,Schneider H,Schroeder C,Buerger K,Müller C,Dorn B,Goldhardt O,Diehl-Schmid J,Förstl H,Steimer W,Grimmer T

更新日期：2020-05-21 00:00:00

abstract：:Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. TP53 Mutation or dysfunction correlates with poor or no survival outcome in CPCs. Here, we report the case of a 4 month-old female who presented with dissemin...

journal_title：Frontiers in pharmacology

authors： Cornelius A,Foley J,Bond J,Nagulapally AB,Steinbrecher J,Hendricks WPD,Rich M,Yendrembam S,Bergendahl G,Trent JM,Sholler GS

更新日期：2017-09-25 00:00:00

abstract：:Osteosarcoma (OS) is the most common bone cancer worldwide. There is evidence that microRNA-409 (miR-409-3p) is involved in tumorigenesis and cancer progression, however, its possible role in OS requires clarification. In the present study, we evaluated the expression level, clinical significance, and mode of action o...

journal_title：Frontiers in pharmacology

authors： Wu L,Zhang Y,Huang Z,Gu H,Zhou K,Yin X,Xu J

更新日期：2019-02-21 00:00:00

abstract：:Cucurbitacin C (CuC), a novel analogue of triterpenoids cucurbitacins, confers a bitter taste in cucumber. Genes and signaling pathways responsive for biosynthesis of CuC have been identified in the recent years. In the present study, we explored the anti-cancer effects of CuC against human cancers in vitro and in viv...

journal_title：Frontiers in pharmacology

authors： Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

更新日期：2019-11-08 00:00:00

abstract：UNLABELLED:Gender-related differences in the pharmacological effects of drug are an emerging topic. This review examines gender differences in both pharmacokinetic and pharmacodynamic aspects of methadone, a long-acting opioid agonist that is prescribed as a treatment for opioid dependence and the management of chronic...

journal_title：Frontiers in pharmacology

authors： Graziani M,Nisticò R

更新日期：2015-06-09 00:00:00

abstract：:Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiologica...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Yu T,Peng L,Sun Q,Wei Y,Han B

更新日期：2020-05-06 00:00:00

abstract：:Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

journal_title：Frontiers in pharmacology

authors： Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

更新日期：2018-02-13 00:00:00

abstract：:Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases. Tanshinones are the main active ingredients in S. miltiorrhiza and exhi...

journal_title：Frontiers in pharmacology

authors： Jiang Z,Gao W,Huang L

更新日期：2019-03-14 00:00:00

abstract：:Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with electrophysiological re...

journal_title：Frontiers in pharmacology

authors： Latapiat V,Rodríguez FE,Godoy F,Montenegro FA,Barrera NP,Huidobro-Toro JP

更新日期：2017-12-15 00:00:00

abstract：:The recent approval of a therapeutic for a circadian disorder has increased interest in developing additional medicines for disorders characterized by circadian disruption. However, previous experience demonstrates that drug development for central nervous system (CNS) disorders has a high failure rate. Personalized m...

journal_title：Frontiers in pharmacology

authors： Skelton RL,Kornhauser JM,Tate BA

更新日期：2015-06-19 00:00:00

abstract：Introduction:Practical adherence barriers (e.g., medication frequency) are generally more amenable to intervention than perceptual barriers (e.g., beliefs). Measures which assess adherence barriers exist, however these tend to measure a mix of factors. There is a need to identify what practical barriers are captured by...

journal_title：Frontiers in pharmacology

authors： Chan AHY,Cooper V,Lycett H,Horne R

更新日期：2020-05-13 00:00:00

abstract：:Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of this study was to inve...

journal_title：Frontiers in pharmacology

authors： Kong LL,Shen GL,Wang ZY,Zhuang XM,Xiao WB,Yuan M,Gong ZH,Li H

更新日期：2016-08-09 00:00:00

abstract：:We aimed to ascertain the mechanism underlying the effects of acteoside (ACT) from Ligustrum robustum (Roxb.) Blume (Oleaceae) on lipid metabolism and synthesis. ACT, a water-soluble phenylpropanoid glycoside, is the most abundant and major active component of L. robustum; the leaves of L. robustum, known as kudingcha...

journal_title：Frontiers in pharmacology

authors： Sun L,Yu F,Yi F,Xu L,Jiang B,Le L,Xiao P

更新日期：2019-05-24 00:00:00

abstract：:Disruptions in iron homeostasis are linked to a broad spectrum of chronic conditions including cardiovascular, malignant, metabolic, and neurodegenerative disease. Evidence supporting this contention derives from a variety of analytical approaches, ranging from molecular to population-based studies. This review focuse...

journal_title：Frontiers in pharmacology

authors： Basuli D,Stevens RG,Torti FM,Torti SV

更新日期：2014-05-20 00:00:00

abstract：:Many ion channels are involved in tumor development, promoting cancer cell proliferation, migration, invasion, and survival. Accordingly, some of them have been suggested as tumor markers and novel targets for cancer therapy. Some sex steroid hormones (SSH), including estrogens and androgens, favor cancer progression....

journal_title：Frontiers in pharmacology

authors： Restrepo-Angulo I,Bañuelos C,Camacho J

更新日期：2020-02-28 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of altern...

journal_title：Frontiers in pharmacology

authors： Batke M,Gütlein M,Partosch F,Gundert-Remy U,Helma C,Kramer S,Maunz A,Seeland M,Bitsch A

更新日期：2016-09-21 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine-like or paracrine-like delivery. Here experiments have been designed to demonstrate whether gap junction hemichannels, composed of c...

journal_title：Frontiers in pharmacology

authors： Valiunas V

更新日期：2013-06-06 00:00:00