Abstract:
BACKGROUND:The study of osteoblasts and their osteogenic functions is essential in order to understand them and their applications in implantology. In this sense, this study try to study BMP-2 production and bone matrix deposition, in addition to other biological variables, in osteoblasts cultured on a rough double acid-etched titanium surface (Osseotite®, Biomet 3i, Palm Beach Garden, Florida, USA) in comparison to a smooth titanium surface (machined) and a control Petri dish. MATERIALS AND METHODS:An in vitro prospective study. NHOst human osteoblasts from the femur were cultured on three different surfaces: Control group: 25-mm methacrylate dish (n = 6); Machined group: titanium discs with machined surface (n = 6) and Experimental group: titanium discs with a double acid-etched nitric and hydrofluoric Osseotite® acid surface (n = 6). A quantification of the mitochondrial membrane potential, and studies of apoptosis, mobility and adhesion, bone productivity (BMP-2) and cellular bone synthesis were carried out after culturing the three groups for forty-eight hours. RESULTS:A statistically significant difference was observed in the production of BMP-2 between the experimental group and the other two groups (22.33% ± 11.06 vs. 13.10% ± 5.51 in the machined group and 3.88% ± 3.43 in the control group). Differences in cellular bone synthesis were also observed between the groups (28.34% ± 14.4% in the experimental group vs. 20.03% ± 6.79 in the machined group and 19.34% ± 15.93% in the control group). CONCLUSIONS:In comparison with machined surfaces, Osseotite® surfaces favor BMP-2 production and bone synthesis as a result of the osteoblasts in contact with it.
journal_name
Med Oral Patol Oral Cir Bucaljournal_title
Medicina oral, patologia oral y cirugia bucalauthors
Velázquez-Cayón R,Castillo-Dalí G,Corcuera-Flores JR,Serrera-Figallo MA,Castillo-Oyagüe R,González-Martín M,Gutierrez-Pérez JL,Torres-Lagares Ddoi
10.4317/medoral.22071subject
Has Abstractpub_date
2017-09-01 00:00:00pages
e651-e659issue
5eissn
1698-4447issn
1698-6946pii
22071journal_volume
22pub_type
杂志文章abstract:OBJECTIVES:Recent developments of new direct oral anticoagulants that target specific clotting factors necessitate understanding of coagulation biology. The objective of this tutorial is to offer dental professionals a review of coagulation mechanisms and the pharmacodynamics of the conventional and new oral anticoagul...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:10.4317/medoral.19140
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Determine the behavior of the maxillofacial trauma of adults treated in 3 tertiary care centers in the central zone of Chile. MATERIAL AND METHODS:descriptive, cross-sectional, multicenter study, based on the prospective records of maxillofacial trauma cases attended between May 2016 and April 2017 by denta...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,多中心研究
doi:10.4317/medoral.22985
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Several studies have focused on the relationship among serotype distribution, ethnical status and geographic populations, and periodontal conditions. Studies that have investigated the prevalence and the distribution of A. actinomycetemcomitans serotypes and the relation between the different serotypes of the...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:10.4317/medoral.19304
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:As important effector cells of the innate immune system, neutrophils are involved in rejection of solid organ and/or tissue transplants. But their role in rejection of oral mucosa transplantation (OMT) remains unclear. The aim of this study is to observe the spatial-temporal change of neutrophils during ac...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.16.e341
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:The principle of the intraosseous anesthesia (IOA) relies on the perforation of the cortical plate of the bone for direct application of the local anesthetic solution into the underlying cancellous structures. During this procedure, IOA needles might accidentally come in contact with the tooth roots. The aim...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18386
更新日期:2013-01-01 00:00:00
abstract::The odontogenic myxoma is a rare entity located in mandible and upper maxilla. Due to its local aggressiveness, wide surgical excision is mandatory. Several surgical techniques have been described for the reconstruction of segmental mandibular defects. In comparison with other free flaps, the vascularized free fibular...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:The objective was to present a novel technique for antrostomy performed before sinus elevation in atrophic maxilla for subsequent implant placement. MATERIAL AND METHODS:The study included 10 sinus elevations performed by the proposed technique in nine consecutive patients presenting with inadequate posteri...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:This study aims to assess, in the population of patients with oral cancer treatment, the influence on the quality of life of two protocols of dental treatment: not ruled hospital treatment versus ruled hospital treatment. Matrial and Methods: A quasi-experimental approach justified on ethical grounds was use...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.22353
更新日期:2018-07-01 00:00:00
abstract:AIM:To visualize by atomic force microscopy the alterations induced on Enterococcus. faecalis surface after treatment with 2 types of laser: Erbium chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser and Diode laser. MATERIAL AND METHODS:Bacterial suspensions from overnight cultures of E. faecalis were irradia...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.19991
更新日期:2015-01-01 00:00:00
abstract::The use of medicines during pregnancy deserves special attention from dentists due to the potential risks to fetal development. The prescription of antimicrobial drugs during this period must be based not only on the etiology of the disease but also on the drug's effect on the embryo, which may be toxic, possibly lead...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the presence of human papillomavirus (HPV) in saliva rinses of patients with oral squamous cell carcinoma and to analyze the possibility of using saliva as a diagnostic method for screening high-risk patients. STUDY DESIGN:The saliva sample of 22 patients with oral squam...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.14.e525
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Human cytomegalovirus (HCMV) appears to be more frequent in periodontally affected patients than in healthy control groups. Based on this assumption, it has been suggested that HCMV may play a role in the pathogenesis of periodontal disease. OBJECTIVE:The objective of this uncontrolled study was to assess t...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.15.e292
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:To describe the clinicopathologic profile of young patients with head and neck squamous cell carcinoma (HNSCC) and compare to middle-aged and elderly adults. MATERIAL AND METHODS:Patients' individual records were reviewed for clinicopathologic data. Eighty-nine patients with age 18-45 years old met the incl...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.23461
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Whole Slide Imaging (WSI) is an alternative method to light microscopy (LM). However, few studies have compared the diagnostic agreement between WSI and LM, especially to grade oral epithelial dysplasia (OED). The purpose of this study was to evaluate the variability in grading OED by the World Health Organi...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,多中心研究
doi:10.4317/medoral.23854
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Evaluation of the efficacy and safety of a mandibular advancement device (MAD) (KlearwayTM) in the treatment of mild-to-moderate obstructive sleep apnea and chronic roncopathy. MATERIAL AND METHODS:A randomized, placebo-controlled, double blinded, and crossover clinical trial was conducted. Placebo device (...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:10.4317/medoral.20649
更新日期:2015-09-01 00:00:00
abstract::Traumatic neuromas are rare entities which characteristically arise subsequently to surgery and are usually accompanied by pain, typically neuralgic. We present an unusual case of an intraosseous traumatic neuroma of the inferior alveolar nerve following tooth extraction. A 56-year-old man consulted for paresthesias a...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Odontogenic keratocyst (OKC) is an odontogenic developmental cyst that presents distinct clinical behavior. This lesion has been described as dental cysts with keratinization since the 1930s, however the term OKC was established in 1956. This study aims to determine the frequency and features of OKC in child...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.23185
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:This article presents the results of a retrospective study of the frequency and classification of odontogenic tumors recorded at four centers of diagnostic pathology in Rio de Janeiro, Brazil. STUDY DESIGN:All medical records and microscopic slides of odontogenic tumor specimens for the years 1997 to 2007 we...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,多中心研究
doi:10.4317/medoral.17630
更新日期:2012-05-01 00:00:00
abstract::Brown tumor is one of the lesions that develop in patients with hyperparathyroidism. Any of the skeletal bones can be affected including the cranio-maxillofacial ones. Most of the times the brown tumor appears after a final diagnosis of hyperparathyroidism is made. However brown tumor can be the first clinical sign of...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Relapse of granulomatous epulis is common after surgery because of local irritations, hormonal level in vivo, or incomplete resection. Currently, if recurrence occurs, then extraction of the teeth adjacent to the lesion is commonly performed, which may influence the aesthetics or masticatory function. Thus, ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.21422
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Dabigatran is a newly commercialized drug that is replacing other anticoagulants in the prevention of venous thromboembolism, stroke and systemic arterial valve embolism. It acts directly on thrombin presenting in a dynamic and predictable way, which does not require monitoring these patients. Therefore, we ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:10.4317/medoral.21202
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. B...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:10.4317/medoral.21281
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:To determine the incidence, severity and duration of lingual tactile and gustatory function impairments after lower third molar removal. STUDY DESIGN:Prospective cohort study with intra-subject measures of 16 patients undergoing lower third molar extractions. Sensibility and gustatory functions were evaluat...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.17890
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:A single-blinded randomized controlled trial among patients requiring an upper third molar extraction was performed to evaluate the anxiety degree after receiving information or not about the functioning of The Wand system. Secondarily, perceived pain and the need of re-anesthesia were assessed. MATERIAL AN...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:10.4317/medoral.23315
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To describe and discuss the design, building and usefulness of tissue microarray (TMA) blocks for the study of salivary gland tumors (SGTs). STUDY DESIGN:Two hundred thirty-eight formalin-fixed, paraffin-embedded SGTs were arranged in blocks of TMA using a manual tissue arrayer. Three representative cores of...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18204
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Oral ulcers caused by methotrexate (MTX) at low doses are a known side effect of this drug. Although increasingly more patients are medicated with MTX, these painful ulcers, without traumatic origin and resistant to any type of treatment, are not usually identified by health professionals as a side effect of...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.22851
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To determine the epidemiology and describe the clinical and radiographic characteristics, the type of treatment, and the possible delayed appearance of new supernumerary teeth in patients with non-syndromic multiple hyperdontia. PATIENTS AND METHODS:We conducted a small retrospective observational study of ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:After maxillectomy, prosthetic restoration of the resulting defect is an essential step because it signals the beginning of patient's rehabilitation. The obturator used to restore the defect should be comfortable, restore adequate speech, deglutition, mastication, and be cosmetically acceptable, success will...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.17482
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Bromelain is a cysteine protease isolated from pineapple with a range of biological properties including platelet aggregation inhibition and anti-inflammatory effects. Recent studies have evaluated the clinical implications of bromelain in reducing postoperative inflammatory complications after third molar s...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,meta分析
doi:10.4317/medoral.22731
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Antiplatelet drugs are used to treat and prevent a wide range of cardiovascular pathologies and/or cerebrovascular accidents. Although the use of anticoagulants in dental extractions is highly protocolized, a clear control method has not yet been established for antiplatelet drugs. This study is directed at ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.14.e588
更新日期:2009-11-01 00:00:00