Abstract：
OBJECTIVES:Recent developments of new direct oral anticoagulants that target specific clotting factors necessitate understanding of coagulation biology. The objective of this tutorial is to offer dental professionals a review of coagulation mechanisms and the pharmacodynamics of the conventional and new oral anticoagulants. Also, we summarized the dental implications of the conventional and new anticoagulants. METHOD:We searched Medline using search terms "antithrombotic", "antihemostasis" or "anticoagulation" and combined them with the search results of "dental", "oral surgery" or "periodontal". We restricted the results to "human" and "English". RESULTS:The early coagulation cascade, the new cell-based coagulation model, the pharmacokinetics and pharmacodynamics of conventional antithrombotics, and new oral anticoagulants were reviewed. The new direct factor Xa inhibitors and the direct thrombin inhibitor (s), called direct oral anticoagulants (DOAs) have rapid onset of action, fast elimination on cessation, and fewer drug-drug or drug-food interactions than warfarin. However, the lack of antidotes raises concerns that some dental procedures may trigger serious hemorrhagic events. Additionally, careful perioperative withdrawal and resumption protocols for the DOAs are reviewed, because DOAs' blood levels are dependent on renal function. Also, various reversal strategies in the event of excessive bleedings are summarized. Perioperative management of dental patients taking new DOAs and conventional oral anticoagulants are also discussed. However, the perioperative strategies for DOAs are yet to be validated in randomized trials.
journal_name
Med Oral Patol Oral Cir Bucaljournal_title
Medicina oral, patologia oral y cirugia bucalauthors
Fakhri HR,Janket SJ,Jackson EA,Baird AE,Dinnocenzo R,Meurman JHdoi
10.4317/medoral.19140subject
Has Abstractpub_date
2013-05-01 00:00:00pages
e461-72issue
3eissn
1698-4447issn
1698-6946pii
19140journal_volume
18pub_type
杂志文章,评审abstract：OBJECTIVES:The purpose of this study was to make a descriptive approximation of the therapeutic management of the different dental interventions in clinical practice today, and to analyze the degree of consensus among the specialists participating in the study. STUDY DESIGN:A total of 447 odontologists, stomatologists...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.16.e573
更新日期：2011-07-01 00:00:00
abstract：:Angioleiomyoma is an uncommon benign soft tissue tumor usually found in the lower extremities and rarely observed in oral tissues. It is microscopically characterized as a proliferation of smooth muscle cells intermingled with abundant vascular channels. Oral angioleiomyomas affect mostly the lips, palate, buccal muco...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.16.e482
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Lichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literatu...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.21606
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the immunohistochemical expression of NF-κB and IL-6 in oral premalignant and malignant lesions and to investigate their possible correlation with the presence of subepithelial inflammation. MATERIAL AND METHODS:Thirty two oral premalignant lesions, clinically compa...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.20570
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The odontogenic cystic lesions happened in the angle and ramus region are frequently associated with impacted mandibular third molars. The treatment plan was difficult to work out for the huge cystic lesions with deeply impacted third molars, since the enucleation with simultaneously removing the deeply impa...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.21814
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:Assessment of the oral health-related quality of life and the modulating factors of patients demanding dental treatment in the city of Salamanca, through the use of two validated instruments: the OIDP-sp (Oral Impacts on Daily Performance) and OHIP-14 (Oral Health Impact Profile). STUDY DESIGN:the study was...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.16790
更新日期：2011-09-01 00:00:00
abstract：:Burning mouth syndrome (BMS) refers to chronic orofacial pain, unaccompanied by mucosal lesions or other evident clinical signs. It is observed principally in middle-aged patients and postmenopausal women. BMS is characterized by an intense burning or stinging sensation, preferably on the tongue or in other areas of t...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.15.e562
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:This study aims to assess, in the population of patients with oral cancer treatment, the influence on the quality of life of two protocols of dental treatment: not ruled hospital treatment versus ruled hospital treatment. Matrial and Methods: A quasi-experimental approach justified on ethical grounds was use...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.22353
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study is to investigate the prevalence of the dental patients who had a history of hepatitis. STUDY DESIGN:A total of 13.527 records of patients who were examined between October 1, 2002 and October 1, 2004 were reviewed retrospectively. The medical histories of patients were taken before rou...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:Sjögren's syndrome is a chronic inflammatory disease. The detection of chronic inflammatory infiltrates containing >50 lymphocytes (lymphocytic focus) per 4 mm2 tissue in minor salivary gland biopsies is a diagnostic parameter of the disease. The aim of the study was to examine if an increase in the tissue a...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:The aim of this work was to assess the antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on virulence factors of Candida albicans. STUDY DESIGN:Ten isolated strains of Candida albicans obtained from 10 patients with oral candidiasis and a collection strain of...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.16.e23
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:This study aimed to identify (1) the predilection site of postoperative infection after third molar extraction surgery, (2) risk factors associated with postoperative infection, and (3) the cause of the difference between delayed- and early-onset infections. MATERIALS AND METHODS:This retrospective study in...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.22556
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its intensity. The objective of this study was to determine the effect of zinc in OM in children with acut...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.23798
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options. Understanding the pathogenesis and biological aspects of these tumors would improve the success of diagnose and treatment procedures. The...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Mandibular sagittal split osteotomy (MSSO) may incur unfavorable split and sensorineural injuries. Knowledge of the anatomic location of the mandibular canal (MC) and bone thickness in the region of interest for MSSO, and the possible variations by age and gender can assist in avoiding such complications. Pu...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.22969
更新日期：2019-07-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION:Frey's Syndrome is defined by facial hyperhidrosis in the preauricular region unleashed by gustatory stimulus and caused mainly by parotidectomy. Several treatment and prevention measures have been proposed, with no conclusive results. Recently, injections of Botulinum Toxin have been suggested, obtaining ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT) are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. The aim of the present work was to perform a retrospective study of OT in patients age...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the vertical misfit between different brands of dental implants and prosthetic abutments, with or without mechanical torque, and to study their possible combination. STUDY DESIGN:Five different brands of implant were used in the study: Biofit (Castemaggiore, Italy), Bioner S.A. (Barcelona, Spain)...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.18137
更新日期：2013-03-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,多中心研究,评审
doi：10.4317/medoral.22473
更新日期：2018-11-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.18372
更新日期：2013-01-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.15.e936
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the cour...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.23940
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:The objective was to analyze the impact of preventive programmes on oral quality of life in school students aged 11-12 yrs. STUDY DESIGN:In the school year 1996/97, a quasi-experimental study was initiated in Granada province with four groups of students aged 6-7 yrs: Sealant + Fluoride (sealants on first p...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:Liposarcomas represent between 15 and 18% of all sarcomas with the most common site being the extremities and retroperitoneum. Liposarcomas of the head and neck are rare, with an estimated incidence representing 3 to 5.6% of all liposarcomas. Liposarcomas most commonly present in the soft tissues of the neck. Primary ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.20866
更新日期：2016-03-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
abstract：:The evaluation of bone regeneration and peri-implantary bone apposition requires laboratory techniques that allow the evaluation of hard tissues without needing to decalcify them. In this study, we describe the cutting-grinding procedure (EXAKT system) for obtaining samples of undecalcified bone and aim to establish t...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:The Vertical Alveolar Distraction Osteogenesis (VADO) technique is an excellent solution for bone and soft tissue neoformation in areas in which there has been significant bone atrophy that hinders normal rehabilitation using dental implants. The goal of this systematic review is to analyze the most relevant...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.22645
更新日期：2018-11-01 00:00:00
abstract：UNLABELLED:Diabetes mellitus type 2 is the most common metabolic disorder and it causes an important morbimortality. The structural modifications in the parotid gland (sialosis) had already been described in these patients and could result in variations in the salivary composition, as well as an increase in periodontal...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
